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  1. Angiotensin-(1-7) is a beneficial hormone of the renin-angiotensin system known to play a positive role in regulation of blood pressure and glucose homeostasis. Previous studies have shown that in high-fat die...

    Authors: Melissa C. White, Amanda J. Miller, Justin Loloi, Sarah S. Bingaman, Biyi Shen, Ming Wang, Yuval Silberman, Sarah H. Lindsey and Amy C. Arnold

    Citation: Biology of Sex Differences 2019 10:36

    Content type: Research

    Published on:

  2. Stress is an important contributor to myocardial ischemia and the progression of coronary artery disease (CAD), and women are more susceptible than men to these effects. Little is known, however, about the neu...

    Authors: Nicole Kasher, Matthew T. Wittbrodt, Zuhayr S. Alam, Bruno B. Lima, Jonathon A. Nye, Carolina Campanella, Stacy Ladd, Muhammad Hammadah, Amit J. Shah, Paolo Raggi, Arshed A. Quyyumi, Viola Vaccarino and J. Douglas Bremner

    Citation: Biology of Sex Differences 2019 10:35

    Content type: Research

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  3. Chronic inflammation and impaired sleep increase the risk for cardiovascular disease. Menopausal women may be particularly at risk as a result of impaired sleep. The objective of the current investigation was ...

    Authors: Bianca D’Antono and Véronique Bouchard

    Citation: Biology of Sex Differences 2019 10:34

    Content type: Research

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  4. Although some recent studies have indicated an association between metabolic syndrome (MetS) and musculoskeletal disease, little is known about the association of MetS with low back pain (LBP). The present stu...

    Authors: Takahiko Yoshimoto, Hirotaka Ochiai, Takako Shirasawa, Satsue Nagahama, Akihito Uehara, Shogo Sai and Akatsuki Kokaze

    Citation: Biology of Sex Differences 2019 10:33

    Content type: Research

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  5. Studies assessing volumetric sex differences have provided contradictory results. Total intracranial volume (TIV) is a major confounding factor when estimating local volumes of interest (VOIs). We investigated...

    Authors: Carla Sanchis-Segura, Maria Victoria Ibañez-Gual, Jesús Adrián-Ventura, Naiara Aguirre, Álvaro Javier Gómez-Cruz, César Avila and Cristina Forn

    Citation: Biology of Sex Differences 2019 10:32

    Content type: Research

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  7. It is well documented that the metabolic syndrome predisposes patients to increased cardiovascular risk. Emerging data indicates that cardiovascular risk conferred by metabolic syndrome is highly dependent on ...

    Authors: Jessica L. Faulkner and Eric J. Belin de Chantemèle

    Citation: Biology of Sex Differences 2019 10:30

    Content type: Review

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  8. Key differences exist between men and women in the determinants and manifestations of cardiovascular and cardiometabolic diseases. Recently, gut microbiome-host relations have been implicated in cardiovascular...

    Authors: Alexander C. Razavi, Kaitlin S. Potts, Tanika N. Kelly and Lydia A. Bazzano

    Citation: Biology of Sex Differences 2019 10:29

    Content type: Review

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  11. There are sex differences in risk for stroke and small vessel ischemic disease in the brain. Microvesicles (MV) derived from activated cells vary by cell of origin and the stimulus initiating their release. MV...

    Authors: Larry W. Hunter, Muthuvel Jayachandran and Virginia M. Miller

    Citation: Biology of Sex Differences 2019 10:26

    Content type: Research

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  12. Adipocytes and macrophages, the two major constituents of adipose tissue, exhibit sex differences and work in synergy in adipose tissue physiology and pathophysiology, including obesity-linked insulin resistan...

    Authors: Yang Xin Zi Xu, Geetika Bassi and Suresh Mishra

    Citation: Biology of Sex Differences 2019 10:25

    Content type: Review

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  13. African Americans (AA) develop hypertension (HTN) at an earlier age, have a greater frequency and severity of HTN, and greater prevalence of uncontrolled HTN as compared to the white population. Mineralocortic...

    Authors: John S. Clemmer, Jessica L. Faulkner, Alex J. Mullen, Kenneth R. Butler and Robert L. Hester

    Citation: Biology of Sex Differences 2019 10:24

    Content type: Research

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  14. Knee osteoarthritis (OA) is among the most common and disabling persistent pain conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men. In the USA, the gr...

    Authors: Meghna Nandi, Kristin L. Schreiber, Marc O. Martel, Marise Cornelius, Claudia M. Campbell, Jennifer A. Haythornthwaite, Michael T. Smith Jr., John Wright, Linda S. Aglio, Gary Strichartz and Robert R. Edwards

    Citation: Biology of Sex Differences 2019 10:23

    Content type: Research

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  16. Exposure to an adverse environment in early life can have lifelong consequences for risk of cardiovascular disease. Maternal alcohol (ethanol) intake is common and associated with a variety of harmful effects ...

    Authors: Sarah L. Walton, Melissa Tjongue, Marianne Tare, Edmund Kwok, Megan Probyn, Helena C. Parkington, John F. Bertram, Karen M. Moritz and Kate M. Denton

    Citation: Biology of Sex Differences 2019 10:21

    Content type: Research

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  17. Antarctica challenges human explorers by its extreme environment. The effects of these unique conditions on the human physiology need to be understood to best mitigate health problems in Antarctic expedition c...

    Authors: C. Strewe, D. Moser, J.-I. Buchheim, H.-C. Gunga, A. Stahn, B. E. Crucian, B. Fiedel, H. Bauer, P. Gössmann-Lang, D. Thieme, E. Kohlberg, A. Choukèr and M. Feuerecker

    Citation: Biology of Sex Differences 2019 10:20

    Content type: Research

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  18. The obesity-related risk of developing metabolic syndrome is higher in males than in females of reproductive age, likely due to estrogen-mediated reduced adipose tissue inflammation and fibrosis with hypertrop...

    Authors: Sujoy Ghosh, Jessica L. Taylor, Tamra M. Mendoza, Thanh Dang, David H. Burk, Yongmei Yu, Gail Kilroy and Z. Elizabeth Floyd

    Citation: Biology of Sex Differences 2019 10:19

    Content type: Research

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    The Correction to this article has been published in Biology of Sex Differences 2019 10:38

  19. .

    Authors: Parisa Amiri, Golnaz Vahedi-Notash, Parisa Naseri, Davood Khalili, Seyed Saeed Hashemi Nazari, Yadollah Mehrabi, Ali Reza Mahdavi Hazaveh, Fereidoun Azizi and Farzad Hadaegh

    Citation: Biology of Sex Differences 2019 10:18

    Content type: Correction

    Published on:

    The original article was published in Biology of Sex Differences 2019 10:15

  21. Weight loss by surgery or lifestyle changes is strongly recommended for obese individuals to improve metabolic health, but the underlying impairments that persist from a history of obesity remain unclear. Rece...

    Authors: Cameron Griffin, Chelsea R. Hutch, Simin Abrishami, Daria Stelmak, Leila Eter, Ziru Li, Eric Chang, Devyani Agarwal, Brian Zamarron, Mita Varghese, Perla Subbaiah, Ormond A. MacDougald, Darleen A. Sandoval and Kanakadurga Singer

    Citation: Biology of Sex Differences 2019 10:16

    Content type: Research

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  22. The current nationwide study, for the first time, aimed to assess and compare the trend of pre-hypertension and hypertension among urban and rural adolescents in Iran.

    Authors: Parisa Amiri, Golnaz Vahedi-Notash, Parisa Naseri, Davood Khalili, Seyed Saeed Hashemi Nazari, Yadollah Mehrabi, Ali Reza Mahdavi Hazaveh, Fereidoun Azizi and Farzad Hadaegh

    Citation: Biology of Sex Differences 2019 10:15

    Content type: Research

    Published on:

    The Correction to this article has been published in Biology of Sex Differences 2019 10:18

  23. Postoperative cognitive dysfunction (POCD) is a common postoperative complication experienced by patients aged 65 years and older, and these older adults comprise more than one third of the surgical patients i...

    Authors: Katie J. Schenning, Charles F. Murchison, Nora C. Mattek, Jeffrey A. Kaye and Joseph F. Quinn

    Citation: Biology of Sex Differences 2019 10:14

    Content type: Research

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  24. The male predominance in the incidence of nasopharyngeal carcinoma (NPC) suggests the contribution of the X chromosome to the susceptibility of NPC. However, no X-linked susceptibility loci have been examined ...

    Authors: Xiao-Yu Zuo, Qi-Sheng Feng, Jian Sun, Pan-Pan Wei, Yoon-Ming Chin, Yun-Miao Guo, Yun-Fei Xia, Bo Li, Xiao-Jun Xia, Wei-Hua Jia, Jian-Jun Liu, Alan Soo-Beng Khoo, Taisei Mushiroda, Ching-Ching Ng, Wen-Hui Su, Yi-Xin Zeng…

    Citation: Biology of Sex Differences 2019 10:13

    Content type: Research

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  26. The response to overfeeding is sex dependent, and metabolic syndrome is more likely associated to obesity in men or postmenopausal women than in young fertile women. We hypothesized that obesity-induced metabo...

    Authors: Marcela González-Granillo, Luisa A. Helguero, Eliana Alves, Amena Archer, Christina Savva, Matteo Pedrelli, Osman Ahmed, Xidan Li, Maria Rosário Domingues, Paolo Parini, Jan-Åke Gustafsson and Marion Korach-André

    Citation: Biology of Sex Differences 2019 10:11

    Content type: Research

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  27. Following publication of the original article [1], we noticed a number of errors.

    Authors: Katsuya Uchida, Hiroko Otsuka, Masahiro Morishita, Shinji Tsukahara, Tatsuya Sato, Kenji Sakimura and Keiichi Itoi

    Citation: Biology of Sex Differences 2019 10:10

    Content type: Correction

    Published on:

    The original article was published in Biology of Sex Differences 2019 10:6

  28. Orphanin FQ (aka nociceptin; N/OFQ) binds to its nociceptin opioid peptide (NOP) receptor expressed in proopiomelanocortin (POMC) neurons within the arcuate nucleus (ARC), a critical anorexigenic component of ...

    Authors: Jennifer Hernandez, Carolina Fabelo, Lynnea Perez, Clare Moore, Rachel Chang and Edward J. Wagner

    Citation: Biology of Sex Differences 2019 10:9

    Content type: Research

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  29. Maladaptive remodeling in pressure overload (PO)-induced left ventricular hypertrophy (LVH) may lead to heart failure. Major sex differences have been reported in this process. The steroid hormone 17β-estradio...

    Authors: Hugo Sanchez-Ruderisch, Ana Maria Queirós, Daniela Fliegner, Claudia Eschen, Georgios Kararigas and Vera Regitz-Zagrosek

    Citation: Biology of Sex Differences 2019 10:8

    Content type: Research

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  30. Cardiovascular diseases (CVDs) culminating into heart failure (HF) are major causes of death in men and women. Prevalence and manifestation, however, differ between sexes, since men mainly present with coronar...

    Authors: Elise L. Kessler, Mathilde R. Rivaud, Marc A. Vos and Toon A. B. van Veen

    Citation: Biology of Sex Differences 2019 10:7

    Content type: Review

    Published on:

  31. The bed nucleus of the stria terminalis (BNST) contains the highest density of corticotropin-releasing factor (CRF)-producing neurons in the brain. CRF-immunoreactive neurons show a female-biased sexual dimorp...

    Authors: Katsuya Uchida, Hiroko Otsuka, Masahiro Morishita, Shinji Tsukahara, Tatsuya Sato, Kenji Sakimura and Keiichi Itoi

    Citation: Biology of Sex Differences 2019 10:6

    Content type: Research

    Published on:

    The Correction to this article has been published in Biology of Sex Differences 2019 10:10

  32. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the nervous system. Previous studies have shown fluctuations in expression levels of GABA signaling components—glutamic acid decarbo...

    Authors: Madhavi Pandya, Thulani H. Palpagama, Clinton Turner, Henry J. Waldvogel, Richard L. Faull and Andrea Kwakowsky

    Citation: Biology of Sex Differences 2019 10:5

    Content type: Research

    Published on:

  33. Estrogen is formed by the enzyme aromatase (CYP19A1) and signals via three identified receptors ERα (ESR1), ERß (ESR2), and the G protein-coupled estrogen receptor (GPER). Understanding the relative contributi...

    Authors: Dillion D. Hutson, Rakesh Gurrala, Benard O. Ogola, Margaret A. Zimmerman, Ricardo Mostany, Ryousuke Satou and Sarah H. Lindsey

    Citation: Biology of Sex Differences 2019 10:4

    Content type: Research

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  34. The Fast-Track Action Committee on (the) Health Science and Technology Response to the Opioid Crisis recently released their draft report for public comment. This report provides the “roadmap” for a coordinate...

    Authors: Jill B. Becker and Carolyn M. Mazure

    Citation: Biology of Sex Differences 2019 10:3

    Content type: Commentary

    Published on:

  35. Men are at higher risk of developing chronic lymphocytic leukemia (CLL) than women. DNA methylation has been shown to play important roles in a number of cancers. There are differences in the DNA methylation p...

    Authors: Shuchun Lin, Yun Liu, Lynn R. Goldin, Chen Lyu, Xiangyin Kong, Yan Zhang, Neil E. Caporaso, Song Xiang and Ying Gao

    Citation: Biology of Sex Differences 2019 10:2

    Content type: Research

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  36. The pathogenesis of hypertension is distinct between men and women. Endothelin-1 (ET-1) is a potential contributor to sex differences in the pathophysiology of hypertension. ET-1 participates in blood pressure...

    Authors: Eman Y. Gohar, Anthony K. Cook, David M. Pollock and Edward W. Inscho

    Citation: Biology of Sex Differences 2019 10:1

    Content type: Research

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  37. Atherosclerotic lesions are comprised of distinct regions with different proteomic profiles. Men and women develop differences in lesion phenotype, with lesions from women generally being more stable and less ...

    Authors: Liam J. Ward, Patrik Olausson, Wei Li and Xi-Ming Yuan

    Citation: Biology of Sex Differences 2018 9:54

    Content type: Research

    Published on:

  39. Evidence suggests that epicardial adipose tissue (EAT) is closely related to coronary artery stenosis (CAS). However, sexual dimorphism may be present in adipose tissue, and its influence on CAS between men an...

    Authors: Mi-Na Kim, Seong-Mi Park, Dong-Hyuk Cho, Hack-Lyoung Kim, Mi-Seung Shin, Myung-A Kim, Kyung-Soon Hong and Wan-Joo Shim

    Citation: Biology of Sex Differences 2018 9:52

    Content type: Research

    Published on:

  40. Plasma fibrinogen (FIB) has been demonstrated to be a risk factor for cardiovascular disease. Patients with non-calcified plaque (NCP) or mix plaque (MP) have a higher risk of poor outcomes. However, the assoc...

    Authors: Tiewei Li, Fang Wang, Rui Peng, Shengqiang Pei, Zhihui Hou, Bin Lu, Xiangfeng Cong and Xi Chen

    Citation: Biology of Sex Differences 2018 9:51

    Content type: Research

    Published on:

  41. Women live about 4 years longer due to lower prevalence of cardiovascular complication with ageing. However, the mechanisms involved in the preservation of heart functionality in women have not been fully eluc...

    Authors: Żaneta Piotrowska, Michał Niezgoda, Wojciech Łebkowski, Anna Filipek, Natalia Domian and Irena Kasacka

    Citation: Biology of Sex Differences 2018 9:50

    Content type: Research

    Published on:

  42. Chronic stress is a major contributor in the development of metabolic syndrome and associated diseases, such as diabetes. High-fat diet (HFD) and sex are known modifiers of metabolic parameters. Peptide hormon...

    Authors: Sreenivasan Paruthiyil, Shin-ichiro Hagiwara, Keshav Kundassery and Aditi Bhargava

    Citation: Biology of Sex Differences 2018 9:49

    Content type: Research

    Published on:

  43. Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions of E2 are mediated through the classical estrogen ...

    Authors: Andrea Iorga, Soban Umar, Gregoire Ruffenach, Laila Aryan, Jingyuan Li, Salil Sharma, Negar Motayagheni, Rangarajan D. Nadadur, Jean C. Bopassa and Mansoureh Eghbali

    Citation: Biology of Sex Differences 2018 9:48

    Content type: Research

    Published on:

  44. Non-alcoholic fatty liver disease (NAFLD) encompasses benign steatosis and more severe conditions such as non-alcoholic steatohepatitis (NASH), cirrhosis, and liver cancer. This chronic liver disease has a poo...

    Authors: Zeyneb Kurt, Rio Barrere-Cain, Jonnby LaGuardia, Margarete Mehrabian, Calvin Pan, Simon T Hui, Frode Norheim, Zhiqiang Zhou, Yehudit Hasin, Aldons J Lusis and Xia Yang

    Citation: Biology of Sex Differences 2018 9:46

    Content type: Research

    Published on:

  45. Females and males differ significantly in gross anatomy and physiology of the lower urinary tract, and these differences are commonly discussed in the medical and scientific literature. However, less attention...

    Authors: Benjamin Abelson, Daniel Sun, Lauren Que, Rebecca A Nebel, Dylan Baker, Patrick Popiel, Cindy L Amundsen, Toby Chai, Clare Close, Michael DiSanto, Matthew O Fraser, Stephanie J Kielb, George Kuchel, Elizabeth R Mueller, Mary H Palmer, Candace Parker-Autry…

    Citation: Biology of Sex Differences 2018 9:45

    Content type: Review

    Published on:

  46. Statins are often discontinued in patients with advanced cancer since the net effect of treatment is considered negative. However, guidelines concerning discontinuation of statin treatment are lacking. The aim...

    Authors: Helena Bergström, Elsa Brånvall, Maria Helde-Frankling and Linda Björkhem-Bergman

    Citation: Biology of Sex Differences 2018 9:47

    Content type: Research

    Published on:

  47. Worldwide tuberculosis (TB) reports show a male bias in morbidity; however, the differences in pathogenesis between men and women with TB, as well as the mechanisms associated with such differences, are poorly...

    Authors: Wenling Tan, Adiilah K Soodeen-Lalloo, Yue Chu, Weijie Xu, Fengfang Chen, Jie Zhang, Wei Sha, Jin Huang, Guanghong Yang, Lianhua Qin, Jie Wang, Xiaochen Huang, Jingyun Shi and Yonghong Feng

    Citation: Biology of Sex Differences 2018 9:44

    Content type: Research

    Published on:

  48. Since 1984, each year, more women than men die of ischemic heart disease (IHD) and heart failure (HF), yet more men are diagnosed. Because biomarker assessment is often the first diagnostic employed in such pa...

    Authors: Kimia Sobhani, Diana K. Nieves Castro, Qin Fu, Roberta A. Gottlieb, Jennifer E. Van Eyk and C. Noel Bairey Merz

    Citation: Biology of Sex Differences 2018 9:43

    Content type: Review

    Published on:

  49. Previous studies have shown that women experience greater temporal summation (TS) of pain than men using a repetitive thermal stimulus. These studies, however, did not individualize the thermal stimulus to eac...

    Authors: Abdulaziz Awali, Ali M. Alsouhibani and Marie Hoeger Bement

    Citation: Biology of Sex Differences 2018 9:42

    Content type: Research

    Published on:

  50. Insulin resistance underlies metabolic syndrome and is associated with excess adiposity and visceral fat accumulation, which is more frequently observed in males than females. However, in young females, the pr...

    Authors: Scott Fuller, Yongmei Yu, Tamra Mendoza, David M. Ribnicky, William T. Cefalu and Z. Elizabeth Floyd

    Citation: Biology of Sex Differences 2018 9:41

    Content type: Research

    Published on:

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Biology of Sex Differences

ISSN: 2042-6410

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