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Muscle metabolism and atrophy: let’s talk about sex

In this article, the authors review the literature on sex differences in metabolism and atrophy in muscles. Skeletal muscle health is a strong predictor of overall health and longevity. Pathologies affecting skeletal muscle such as cancer cachexia, intensive care unit treatment, muscular dystrophies, and others are associated with decreased quality of life and increased mortality. Recent research has begun to determine that these muscular pathologies appear to present and develop differently between males and females. However, to our knowledge, there has yet to be a comprehensive review on musculoskeletal differences between males and females and how these differences may contribute to sex differences in muscle pathologies. Herein, we present a review of the current literature on muscle phenotype and physiology between males and females and how these differences may contribute to differential responses to atrophic stimuli.

Aims and scope

Biology of Sex Differences considers manuscripts on all aspects of the effects of sex on biology and disease. Sex has profound effects on physiology and the susceptibility to disease. The function of cells and organs depends on their sex, determined by the interplay among the genome and biological and social environments. The study of sex differences is a discipline in itself, with its own concepts and methods that apply across tissues.

Biology of Sex Differences is the official journal of the Organization for the Study of Sex Differences, and a publication of the Society for Women's Health Research.


  1. Content type: Research


    Authors: Julie Noguerol, Pierre-Jean Roustan, Mikael N’Taye, Léo Delcombel, Corinne Rolland, Laura Guiraud, David Sagnat, Anissa Edir, Chrystelle Bonnart, Alexandre Denadai-Souza, Céline Deraison, Nathalie Vergnolle and Claire Racaud-Sultan

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Calls for Papers

Below are all the current thematic series open for submissions at the journal.

Sex Differences in Response to Androgens: Physiological and Pathophysiological
Guest Editor: Licy Yanes Cardozo, University of Mississippi Medical Center
Submission Deadline: December 1, 2019. 

Hypertension, preeclampsia, renal and cardiovascular disease in pregnancy
Submission Deadline: December 1, 2019

Authors may ask about the suitability of a manuscript for inclusion in any of the above series by submitting an pre-submission enquiry. These should be sent to our Editorial Office by using the Contact Us link on the Submission site

Read our Submission Guidelines
Submit an article to the series.

Submit a Topic

Do you have an idea for a thematic series? Submit your suggestion here. 


Jane Reckelhoff, University of Mississippi Medical Center, USA

Associate Editors
Barbara Alexander, University of Mississippi Medical Center, USA
Kate Denton, Monash Biomedicine Discovery Institute, Monash University, Australia
Vesna Garovic, Mayo Clinic Rochester, USA
Radu Iliescu, Grigore T. Popa University, Romania
Georgios Kararigas, Charité University, Germany

Founding Editor
Arthur P Arnold, University of California, Los Angeles, USA

BSD Best Poster Prize Winner: Amy Inkster

New Content Item

In May 2019, the OSSD held their annual meeting in Washington DC. After evaluating the posters presented at this conference, the Editors have selected a prize winner for the Biology of Sex Differences Best Poster prize, awarded to a poster presenter at the OSSD conference. This year's winner is Amy Inkster for the poster: 

Sex-specific patterns of autosomal DNA methylation in the human placenta.

Amy M Inkster, Victor Yuan, Chaini Konwar, Allison M Matthews, Carolyn J Brown, Wendy P Robinson 

As the winner, Amy is entitled to an APC-waiver for a publication in Biology of Sex Differences and will be featured in a blog post in OnBiology. Congratulations, Amy!

New special collection now publishing

Our special series on the topic of sex differences in obesity, insulin resistance, metabolic syndrome and the microbiome is now publishing. Read the collection of review and research articles here

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OSSD 2020 Meeting: May 4-7 in Marina del Ray, CA

We hope everyone had a great #ossd2019 meeting in Washington, DC and look forward to seeing you all again May 5-7, 2019 at the Marina del Ray Marriott in California.  

Visit the OSSD website to learn more about the 2020 meeting.

Message from the OSSD President

Sabra Klein, OSSD PresidentSabra Klein, President of OSSD

Sabra Klein, PhD, is the current President of the Organization for the Study of Sex Differences, Associate Professor of Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health, and Co-Director of the Johns Hopkins Center for Women’s Health, Sex, and Gender Research.


‘The Organization for the Study of Sex Differences (OSSD) is the only scientific research society dedicated to the study of sex as a biological variable. Through our annual meeting and publications from our members, we seek to promote knowledge that sex impacts every cell, pathway, organ, and disease state in the body. As the biomedical sciences continue to appreciate that the progression, prognosis, pathogenesis, and outcome of diverse diseases differ between the sexes, OSSD and the Biology of Sex Differences are at the forefront, serving as experts in this scientific endeavor.’


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  • Society for Women's Health Research

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