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Aims and scope

Biology of Sex Differences considers manuscripts on all aspects of the effects of sex on biology and disease. Sex has profound effects on physiology and the susceptibility to disease. The function of cells and organs depends on their sex, determined by the interplay among the genome and biological and social environments. The study of sex differences is a discipline in itself, with its own concepts and methods that apply across tissues.

Biology of Sex Differences is the official journal of the Organization for the Study of Sex Differences, and a publication of the Society for Women's Health Research.


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Featured article: Effects of gut-derived endotoxin on anxiety-like and repetitive behaviors in male and female mice

In spite of the ubiquitous nature of endotoxin in the gut, this is the first study to demonstrate that gut-derived endotoxin can initiate anxiety behavior without inducing a generalized sickness response. This study lays the groundwork for future interrogations into connections between gut-derived endotoxin and anxiety and demonstrates that such connections likely differ between the sexes.

BSD-OSSD annual award

Biology of Sex Differences, and the Organization for Study of Sex Differences have established an annual award to highlight the best research published in the journal by OSSD members.

The 2017 winner is Dr. Joanna Floros for the paper by George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani and Joanna Floros and titled: 
SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved 
Biology of Sex Differences 2017, 8:37 (4 December 2017)

OSSD 2018 Meeting: April 30 - May 3 in Atlanta, GA

Logo for OSSD 2018 meeting

Stay informed about the most recent advances in research and policy regarding sex differences in physiology and disease.  Keynote lecture by Nirao Shah; Capstone lecture by Londa Schiebinger. 

Learn more here.

Editor's profile

Arthur P Arnold, Editor-in-Chief

Arthur Arnold is a Distinguished Professor of Integrative Biology and Physiology, and Director of the Laboratory of Neuroendocrinology of the Brain Research Institute, at the University of California, Los Angeles.

 "Sex differences occur in many tissues and diseases. Biology of Sex Differences serves as a forum for discussion of the forces that make females and males different, and the downstream pathways that are affected by sex-specific forces. This information will be critical for discovery of factors, often more prevalent in one sex than the other, that alleviate disease."

Jane ReckelhoffJane Reckelhoff, Editor-in-Chief

Dr. Reckelhoff is currently Professor and Chair of the Department of Cell and Molecular Biology and Director of the Women’s Health Research Center at the University of Mississippi Medical Center in Jackson. 

We are excited to have Dr Reckelhoff joining us as Editor-in Chief on the Biology of Sex Differences given her prominent position as a sex differences researcher and considerable editorial experience on journals such as Gender Medicine, Clinical Therapeutics, and the American Journal of Physiology, Regulatory, Integrative and Comparative Physiology.

Margaret M McCarthy, President of OSSD

Margaret M McCarthy, PhD, is the current President of the Organization for the Study of Sex Differences, and Professor and Chair of Pharmacology at the University of Maryland School of Medicine in Baltimore MD.

"The Organization for the Study of Sex Differences is a scientific organization dedicated to the promotion of knowledge and research on sex and gender differences in biology and medicine. Sex is a biological variable that profoundly influences the physiology of every organ in the body. The frequency, progression and severity of the overwhelming majority of diseases and disorders are influenced by sex. Thus excellence in biomedical science demands that we understand the influence of sex in its entirety. We are excited by the early success of Biology of Sex Differences, which is dedicated to such excellence."


Affiliated with

  • Society for Women's Health Research
  • Society for Women's Health Research

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