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  1. Research

    Severe pulmonary hypertension in aging female apolipoprotein E-deficient mice is rescued by estrogen replacement therapy

    Apolipoprotein E (ApoE) is a multifunctional protein, and its deficiency leads to the development of atherosclerosis in mice. Patients with pulmonary hypertension (PH) have reduced expression of ApoE in lung t...

    Soban Umar, Rod Partow-Navid, Gregoire Ruffenach, Andrea Iorga, Shayan Moazeni and Mansoureh Eghbali

    Biology of Sex Differences 2017 8:9

    Published on: 20 March 2017

  2. Research

    Sex differences in variability across timescales in BALB/c mice

    Females are markedly underinvestigated in the biological and behavioral sciences due to the presumption that cyclic hormonal changes across the ovulatory cycle introduce excess variability to measures of inter...

    Benjamin L. Smarr, Azure D. Grant, Irving Zucker, Brian J. Prendergast and Lance J. Kriegsfeld

    Biology of Sex Differences 2017 8:7

    Published on: 9 February 2017

  3. Research

    Sex differences in the aging pattern of renin–angiotensin system serum peptidases

    Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of...

    A. Fernández-Atucha, A. Izagirre, A. B. Fraile-Bermúdez, M. Kortajarena, G. Larrinaga, P. Martinez-Lage, E Echevarría and J. Gil

    Biology of Sex Differences 2017 8:5

    Published on: 3 February 2017

  4. Research

    Bariatric surgery emphasizes biological sex differences in rodent hepatic lipid handling

    Eighty percent of patients who receive bariatric surgery are women, yet the majority of preclinical studies are in male rodents. Because sex differences drive hepatic gene expression and overall lipid metaboli...

    Bernadette E. Grayson, Ruth Gutierrez-Aguilar, Joyce E. Sorrell, Emily K. Matter, Michelle R. Adams, Philip Howles, Rebekah Karns, Randy J. Seeley and Darleen A. Sandoval

    Biology of Sex Differences 2017 8:4

    Published on: 28 January 2017

  5. Review

    Gender-specific differences in hypothalamus–pituitary–adrenal axis activity during childhood: a systematic review and meta-analysis

    Gender-specific differences in hypothalamus–pituitary–adrenal (HPA) axis activity have been postulated to emerge during puberty. We conducted a systematic review and meta-analysis to test the hypothesis that g...

    Bibian van der Voorn, Jonneke J. Hollanders, Johannes C. F. Ket, Joost Rotteveel and Martijn J. J. Finken

    Biology of Sex Differences 2017 8:3

    Published on: 19 January 2017

  6. Research

    Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones

    Corticotropin-releasing factor overexpressing (CRF-OE) male mice showed an inhibited feeding response to a fast, and lower plasma acyl ghrelin and Fos expression in the arcuate nucleus compared to wild-type (W...

    Lixin Wang, Miriam Goebel-Stengel, Pu-Qing Yuan, Andreas Stengel and Yvette Taché

    Biology of Sex Differences 2017 8:2

    Published on: 13 January 2017

  7. Research

    Pancreatic cancer risk in relation to sex, lifestyle factors, and pre-diagnostic anthropometry in the Malmö Diet and Cancer Study

    Lifestyle factors may influence the risk of developing pancreatic cancer. Whereas cigarette smoking is an established risk factor, the effects of high alcohol intake and obesity are more uncertain. The aim of ...

    Gustav Andersson, Christoffer Wennersten, Signe Borgquist and Karin Jirström

    Biology of Sex Differences 2016 7:66

    Published on: 9 December 2016

  8. Research

    Impact of gonadectomy on blood pressure regulation in ageing male and female rats

    Sexual dimorphism in blood pressure has been associated with differential expression of the angiotensin II (AII) receptors and with activity of the nervous system. It is generally accepted that ageing affects ...

    Wioletta Pijacka, Bethan Clifford, Dawid Walas, Chantal Tilburgs, Jaap A. Joles, Sarah McMullen and Simon C. Langley-Evans

    Biology of Sex Differences 2016 7:64

    Published on: 3 December 2016

  9. Research

    Sex-related differences in the associations between plasma free fatty acid levels and clinical features in patients with hypertrophic cardiomyopathy

    Previous studies have indicated that inefficient energy utilization may play a pivotal role in hypertrophic cardiomyopathy (HCM). However, whether plasma free fatty acid (FFA), a main energy substrate of heart...

    Chengzhi Yang, Changlin Zhang, Jiansong Yuan, Jingang Cui, Shengwen Liu, Fenghuan Hu, Weixian Yang, Xuanye Bi and Shubin Qiao

    Biology of Sex Differences 2016 7:63

    Published on: 25 November 2016

  10. Research

    Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study

    Previous studies have shown that total cholesterol (TC) levels are associated with stroke outcomes, but sex differences in the association between TC levels, especially a low TC level, and ischemic stroke outc...

    Guanen Zhou, Zhongping An, Wenjuan Zhao, Yan Hong, Haolin Xin, Xianjia Ning and Jinghua Wang

    Biology of Sex Differences 2016 7:62

    Published on: 24 November 2016

  11. Research

    Comparisons of chromosome Y-substituted mouse strains reveal that the male-specific chromosome modulates the effects of androgens on cardiac functions

    The C57BL/6J.YA/J mouse strain is a chromosome-substituted line where the original male-specific portion of chromosome Y (MSY) from C57BL/6J mice was substituted for that from A/J mice. In hearts from male C57BL/...

    Samantha D. Praktiknjo, Sylvie Picard and Christian F. Deschepper

    Biology of Sex Differences 2016 7:61

    Published on: 23 November 2016

  12. Research

    Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress

    Biological sex plays a prominent role in the prevalence and severity of a number of important stress-related gastrointestinal and immune-related diseases including IBS and allergy/anaphylaxis. Despite the esta...

    Emily Mackey, Saravanan Ayyadurai, Calvin S. Pohl, Susan D’ Costa, Yihang Li and Adam J. Moeser

    Biology of Sex Differences 2016 7:60

    Published on: 22 November 2016

  13. Research

    Gene-specific sex effects on eosinophil infiltration in leishmaniasis

    Sex influences susceptibility to many infectious diseases, including some manifestations of leishmaniasis. The disease is caused by parasites that enter to the skin and can spread to the lymph nodes, spleen, l...

    Martina Slapničková, Valeriya Volkova, Marie Čepičková, Tatyana Kobets, Matyáš Šíma, Milena Svobodová, Peter Demant and Marie Lipoldová

    Biology of Sex Differences 2016 7:59

    Published on: 22 November 2016

  14. Research

    Sex- and age-related differences in arterial pressure and albuminuria in mice

    Animal models have become valuable experimental tools for understanding the pathophysiology and therapeutic interventions in cardiovascular disease. Yet to date, few studies document the age- and sex-related d...

    Giannie Barsha, Kate M. Denton and Katrina M. Mirabito Colafella

    Biology of Sex Differences 2016 7:57

    Published on: 14 November 2016

  15. Letter to the Editor

    The p.R92W variant of NR5A1/Nr5a1 induces testicular development of 46,XX gonads in humans, but not in mice: phenotypic comparison of human patients and mutation-induced mice

    NR5A1 is the key regulator of adrenal and gonadal development in both humans and mice. Recently, a missense substitution in human NR5A1, p.R92W, was shown to underlie gonadal dysgenesis in genetic males and testi...

    Mami Miyado, Masafumi Inui, Maki Igarashi, Yuko Katoh-Fukui, Kei Takasawa, Akiko Hakoda, Junko Kanno, Kenichi Kashimada, Kenji Miyado, Moe Tamano, Tsutomu Ogata, Shuji Takada and Maki Fukami

    Biology of Sex Differences 2016 7:56

    Published on: 8 November 2016

  16. Commentary

    Workshop summaries from the 2015 Sex and Gender Medical Education Summit: utilization of sex and gender based medical education resources and creating student competencies

    Despite overwhelming evidence that sex and gender are critical factors in the delivery and practice of medicine, there is no unified sex- and gender-based medicine (SGBM) undergraduate medical education curric...

    Alyson J. McGregor, Ana Núñez, Rebecca Barron, Robert Casanova and Eliza Lo Chin

    Biology of Sex Differences 2016 7(Suppl 1):43

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  17. Commentary

    Instructional design framework for the sex and gender-specific health multimedia case-based learning modules

    The goal of the Sex and Gender Specific Health (SGSH) curriculum at the Texas Tech University Health Sciences Center (TTUHSC) is to advance the understanding of sex/gender differences, increase the awareness o...

    Steven M. Crooks, Jongpil Cheon, Robert Casanova and Marjorie Jenkins

    Biology of Sex Differences 2016 7(Suppl 1):49

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  18. Commentary

    Innovative levers for sustainable integration of gender medicine into medical school curricula

    Efforts to integrate gender medicine into medical school curricula have focused largely on the work of individual champions. Online sex and gender materials for undergraduate courses have also been developed a...

    Cara Tannenbaum and Geneviève Moineau

    Biology of Sex Differences 2016 7(Suppl 1):41

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  19. Commentary

    Auditing sex- and gender-based medicine (SGBM) content in medical school curriculum: a student scholar model

    Sex- and gender-based medicine (SGBM) aims to (1) delineate and investigate sex- and gender-based differences in health, disease, and response to treatment and (2) apply that knowledge to clinical care to impr...

    Michael M. Song, Betsy G. Jones and Robert A. Casanova

    Biology of Sex Differences 2016 7(Suppl 1):40

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

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