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Biology of Sex Differences

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  1. Content type: Research

    Gut dysbiosis is observed in several neuropsychiatric disorders exhibiting increases in anxiety behavior, and recent work suggests links between gut inflammation and such disorders. One source of this inflamma...

    Authors: Christopher T. Fields, Benoit Chassaing, Alexandra Castillo-Ruiz, Remus Osan, Andrew T. Gewirtz and Geert J. de Vries

    Citation: Biology of Sex Differences 2018 9:7

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  2. Content type: Research

    Disruption of axonal transport plays a pivotal role in diabetic neuropathy. A sex-dimorphism exists in the incidence and symptomatology of diabetic neuropathy; however, no studies so far have addressed sex dif...

    Authors: Marzia Pesaresi, Silvia Giatti, Roberto Spezzano, Simone Romano, Silvia Diviccaro, Tiziana Borsello, Nico Mitro, Donatella Caruso, Luis Miguel Garcia-Segura and Roberto Cosimo Melcangi

    Citation: Biology of Sex Differences 2018 9:6

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  3. Content type: Correction

    Unfortunately, after publication of this article [1], two errors were noticed. The names of Linnéa Karlsson Lind and Karin Schenck-Gustafsson were formatted incorrectly, attributing incorrect elements to the G...

    Authors: Linnéa Karlsson Lind, Mia von Euler, Seher Korkmaz and Karin Schenck-Gustafsson

    Citation: Biology of Sex Differences 2018 9:5

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    The original article was published in Biology of Sex Differences 2017 8:32

  4. Content type: Research

    Development of the placenta during the late first trimester is critical to ensure normal growth and development of the fetus. Developmental differences in this window such as sex-specific variation are implica...

    Authors: Tania L. Gonzalez, Tianyanxin Sun, Alexander F. Koeppel, Bora Lee, Erica T. Wang, Charles R. Farber, Stephen S. Rich, Lauren W. Sundheimer, Rae A. Buttle, Yii-Der Ida Chen, Jerome I. Rotter, Stephen D. Turner, John Williams III, Mark O. Goodarzi and Margareta D. Pisarska

    Citation: Biology of Sex Differences 2018 9:4

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  5. Content type: Research

    Chronic pain conditions are more prevalent in women, but most preclinical studies into mechanisms of pain generation are performed using male animals. Furthermore, whereas group III and IV nociceptive muscle a...

    Authors: Jessica L. Ross, Luis F. Queme, Jordan E. Lamb, Kathryn J. Green and Michael P. Jankowski

    Citation: Biology of Sex Differences 2018 9:2

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  6. Content type: Research

    Helicobacter pylori causes peptic ulcer disease and gastric cancer only in a subset of infected persons. Sex differences were shown in results of urea breath test (UBT), a commonly used test for the diagnosis of

    Authors: Ido Eisdorfer, Varda Shalev, Sophy Goren, Gabriel Chodick and Khitam Muhsen

    Citation: Biology of Sex Differences 2018 9:1

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  7. Content type: Research

    Sex and age play a role in the prevalence of thyroid dysfunction (TD), but their interrelationship for manifestation of hyper- and hypothyroidism is still not well understood. Using a murine model, we asked wh...

    Authors: Helena Rakov, Kathrin Engels, Georg Sebastian Hönes, Klaudia Brix, Josef Köhrle, Lars Christian Moeller, Denise Zwanziger and Dagmar Führer

    Citation: Biology of Sex Differences 2017 8:38

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  8. Content type: Research

    Human innate host defense molecules, surfactant protein A1 (SP-A1), and SP-A2 differentially affect the function and proteome of the alveolar macrophage (AM). We hypothesized that SP-A genes differentially reg...

    Authors: George T. Noutsios, Nithyananda Thorenoor, Xuesheng Zhang, David S. Phelps, Todd M. Umstead, Faryal Durrani and Joanna Floros

    Citation: Biology of Sex Differences 2017 8:37

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  9. Content type: Research

    Stress is a recognized risk factor for mood and anxiety disorders that occur more often in women than men. Prefrontal brain regions mediate stress coping, cognitive control, and emotion. Here, we investigate s...

    Authors: Alex G. Lee, Megan Hagenauer, Devin Absher, Kathleen E. Morrison, Tracy L. Bale, Richard M. Myers, Stanley J. Watson, Huda Akil, Alan F. Schatzberg and David M. Lyons

    Citation: Biology of Sex Differences 2017 8:36

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  10. Content type: Research

    Systemic lupus erythematosus (SLE) and primary Sjögren’s syndrome (pSS) are autoimmune disorders characterized by autoantibodies, dysregulated B cells, and notably high female-to-male incidence ratios. Genome-...

    Authors: Magdalena Lindén, Jorge I. Ramírez Sepúlveda, Tojo James, Gudny Ella Thorlacius, Susanna Brauner, David Gómez-Cabrero, Tomas Olsson, Ingrid Kockum and Marie Wahren-Herlenius

    Citation: Biology of Sex Differences 2017 8:34

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  11. Content type: Review

    Epidemiologic studies have previously suggested that premenopausal females have reduced incidence of cardiovascular disease (CVD) when compared to age-matched males, and the incidence and severity of CVD incre...

    Authors: Andrea Iorga, Christine M. Cunningham, Shayan Moazeni, Gregoire Ruffenach, Soban Umar and Mansoureh Eghbali

    Citation: Biology of Sex Differences 2017 8:33

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  12. Content type: Letter to the Editor

    Investigating fetal development in mice necessitates the determination of fetal sex. However, whilst the sex of adult and juvenile mice can be readily distinguished from anogenital distance, the sex of fetal a...

    Authors: Simon James Tunster

    Citation: Biology of Sex Differences 2017 8:31

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  13. Content type: Research

    17 Alpha-estradiol (17 α-E2) is a natural, non-feminizing stereoisomer of 17 beta-estradiol (17 β-E2). Whereas much is known about the physiological effects of 17 β-E2, much less is known about 17 α-E2. For ex...

    Authors: Roberta S. Santos, Luciana A. de Fatima, Aaron P. Frank, Everardo M. Carneiro and Deborah J. Clegg

    Citation: Biology of Sex Differences 2017 8:30

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  14. Content type: Research

    Sex-related differences in human thermal and pain sensitivity are the subject of controversial discussion. The goal of this study in a large number of subjects was to investigate sex differences in thermal and...

    Authors: Beate Averbeck, Lena Seitz, Florian P. Kolb and Dieter F. Kutz

    Citation: Biology of Sex Differences 2017 8:29

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  15. Content type: Research

    Pre-implantation embryos exhibit sexual dimorphisms in both primates and rodents. To determine whether these differences reflected sex-biased expression patterns, we generated transcriptome profiles for six 40...

    Authors: Rachael J. Werner, Bryant M. Schultz, Jacklyn M. Huhn, Jaroslav Jelinek, Jozef Madzo and Nora Engel

    Citation: Biology of Sex Differences 2017 8:28

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  16. Content type: Research

    Sexual differentiation of the male brain, and specifically the stress circuitry in the hypothalamus, is primarily driven by estrogen exposure during the perinatal period. Surprisingly, this single hormone prom...

    Authors: Christopher P. Morgan and Tracy L. Bale

    Citation: Biology of Sex Differences 2017 8:27

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  17. Content type: Research

    Women have a higher risk of lethal arrhythmias than men in long QT syndrome type 2 (LQTS2), but the mechanisms remain uncertain due to the limited availability of healthy control human tissue. We have previous...

    Authors: Rita Papp, Glenna C. L. Bett, Agnieszka Lis, Randall L. Rasmusson, István Baczkó, András Varró and Guy Salama

    Citation: Biology of Sex Differences 2017 8:26

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  18. Content type: Research

    Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigat...

    Authors: Jorge I. Ramírez Sepúlveda, Marika Kvarnström, Per Eriksson, Thomas Mandl, Katrine Brække Norheim, Svein Joar Johnsen, Daniel Hammenfors, Malin V. Jonsson, Kathrine Skarstein, Johan G. Brun, Lars Rönnblom, Helena Forsblad-d’Elia, Sara Magnusson Bucher, Eva Baecklund, Elke Theander, Roald Omdal…

    Citation: Biology of Sex Differences 2017 8:25

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  19. Content type: Review

    In adults, hypothalamus–pituitary–adrenal (HPA) axis activity shows sexual dimorphism, and this is thought to be a mechanism underlying sex-specific disease incidence. Evidence is scarce on whether these sex d...

    Authors: Jonneke J. Hollanders, Bibian van der Voorn, Joost Rotteveel and Martijn J. J. Finken

    Citation: Biology of Sex Differences 2017 8:23

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  20. Content type: Research

    The thermoneutral zone (TNZ) is a species-specific range of ambient temperature (T a), at which mammals can maintain a constant body temperature with the lowest metabolic rate. The TNZ ...

    Authors: Kasiphak Kaikaew, Jacobie Steenbergen, Axel P. N. Themmen, Jenny A. Visser and Aldo Grefhorst

    Citation: Biology of Sex Differences 2017 8:24

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  21. Content type: Research

    The 2015 National Institutes of Health (NIH) policy that sex be considered as a biological variable (SABV) is now a critical part of the peer-review process for NIH funding as well as publication in several hi...

    Authors: Anne Freeman, Patrick Stanko, Lily N. Berkowitz, Neanta Parnell, Anastasia Zuppe, Tracy L. Bale, Tracy Ziolek and C. Neill Epperson

    Citation: Biology of Sex Differences 2017 8:22

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