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  1. Content type: Research

    Preeclampsia is a pregnancy-specific hypertensive disorder characterized by impaired angiogenesis. We postulate that senescence of mesenchymal stem cells (MSC), multipotent cells with pro-angiogenic activities...

    Authors: Sonja Suvakov, Hajrunisa Cubro, Wendy M. White, Yvonne S. Butler Tobah, Tracey L. Weissgerber, Kyra L. Jordan, Xiang Y. Zhu, John R. Woollard, Fouad T. Chebib, Natasa M. Milic, Joseph P. Grande, Ming Xu, Tamara Tchkonia, James L. Kirkland, Lilach O. Lerman and Vesna D. Garovic

    Citation: Biology of Sex Differences 2019 10:49

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  2. Content type: Research

    According to the WHO Multicentre Growth Reference Study Group recommendations, boys and girls have different growth trajectories after birth. Our aim was to develop gender-specific fetal growth curves in a low...

    Authors: Sander Galjaard, Lieveke Ameye, Christoph C. Lees, Anne Pexsters, Tom Bourne, Dirk Timmerman and Roland Devlieger

    Citation: Biology of Sex Differences 2019 10:48

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  3. Content type: Research

    Sexual dimorphism in biological responses is a critical knowledge for therapeutic proposals. However, gender differences in intestinal stem cell physiology have been poorly studied. Given the important role of...

    Authors: Julie Noguerol, Pierre-Jean Roustan, Mikael N’Taye, Léo Delcombel, Corinne Rolland, Laura Guiraud, David Sagnat, Anissa Edir, Chrystelle Bonnart, Alexandre Denadai-Souza, Céline Deraison, Nathalie Vergnolle and Claire Racaud-Sultan

    Citation: Biology of Sex Differences 2019 10:47

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  4. Content type: Research

    Expression patterns between males and females vary in every adult tissue, even in organs with no conspicuous dimorphisms such as the heart. While studies of male and female differences have traditionally focus...

    Authors: Daniel F. Deegan, Reza Karbalaei, Jozef Madzo, Rob J. Kulathinal and Nora Engel

    Citation: Biology of Sex Differences 2019 10:46

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  5. Content type: Research

    Obesity increases the risk for hypertension in both sexes, but the prevalence of hypertension is lower in females than in males until menopause, despite a higher prevalence of obesity in females. We previously...

    Authors: Robin Shoemaker, Lisa R. Tannock, Wen Su, Ming Gong, Susan B. Gurley, Sean E. Thatcher, Frederique Yiannikouris, Charles M. Ensor and Lisa A. Cassis

    Citation: Biology of Sex Differences 2019 10:45

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  6. Content type: Research

    Cryptococcus neoformans, the causative agent of cryptococcosis, causes ~ 181,000 deaths annually, with males having a higher incidence of disease than females (7M:3F). The reason for this sex bias remains unclear...

    Authors: Tiffany E. Guess, Joseph Rosen, Natalia Castro-Lopez, Floyd L. Wormley Jr and Erin E. McClelland

    Citation: Biology of Sex Differences 2019 10:44

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  7. Content type: Review

    Skeletal muscle health is a strong predictor of overall health and longevity. Pathologies affecting skeletal muscle such as cancer cachexia, intensive care unit treatment, muscular dystrophies, and others are ...

    Authors: Megan E. Rosa-Caldwell and Nicholas P. Greene

    Citation: Biology of Sex Differences 2019 10:43

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  8. Content type: Research

    Cardiovascular disease increases with age in both sexes. Treatment can require cardiac surgery, where the hearts are pre-treated with protective cardioplegic solution before ischemia and reperfusion (I/R). Whi...

    Authors: Anjali Ghimire, Elise S. Bisset and Susan E. Howlett

    Citation: Biology of Sex Differences 2019 10:42

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  9. Content type: Research

    Males and females exhibit significant differences in metabolism and in brain ischemic stroke and different features of brain ischemic lesions are related to different health outcomes. It is critical to underst...

    Authors: Hailuan Zeng, Weibin Shi, Wenhai Jiang, Shengxiang Rao, Beijian Huang, Hongmei Yan and Xin Gao

    Citation: Biology of Sex Differences 2019 10:40

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  10. Content type: Research

    The incidence and prevalence of musculoskeletal disorders (MSDs) is about twice as high in women compared to men, and those of the neck/shoulder region are particularly high among women. Fatigue and responses ...

    Authors: Annamaria Otto, Kim Emery and Julie N. Côté

    Citation: Biology of Sex Differences 2019 10:39

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  11. Content type: Correction

    Following publication of the original article [1], the authors reported that additional file 1 was incorrect. The corrected additional file 1 is given below.

    Authors: Sujoy Ghosh, Jessica L. Taylor, Tamra M. Mendoza, Thanh Dang, David H. Burk, Yongmei Yu, Gail Kilroy and Z. Elizabeth Floyd

    Citation: Biology of Sex Differences 2019 10:38

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    The original article was published in Biology of Sex Differences 2019 10:19

  12. Content type: Research

    Nicotine exposure enhances Pavlovian conditioned approach (PCA), or the learned approach to reward-predictive cues. While females show elevated approach to conditioned stimuli compared to males, potentially in...

    Authors: Sierra J. Stringfield, Aric C. Madayag, Charlotte A. Boettiger and Donita L. Robinson

    Citation: Biology of Sex Differences 2019 10:37

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  13. Content type: Research

    Angiotensin-(1-7) is a beneficial hormone of the renin-angiotensin system known to play a positive role in regulation of blood pressure and glucose homeostasis. Previous studies have shown that in high-fat die...

    Authors: Melissa C. White, Amanda J. Miller, Justin Loloi, Sarah S. Bingaman, Biyi Shen, Ming Wang, Yuval Silberman, Sarah H. Lindsey and Amy C. Arnold

    Citation: Biology of Sex Differences 2019 10:36

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  14. Content type: Research

    Stress is an important contributor to myocardial ischemia and the progression of coronary artery disease (CAD), and women are more susceptible than men to these effects. Little is known, however, about the neu...

    Authors: Nicole Kasher, Matthew T. Wittbrodt, Zuhayr S. Alam, Bruno B. Lima, Jonathon A. Nye, Carolina Campanella, Stacy Ladd, Muhammad Hammadah, Amit J. Shah, Paolo Raggi, Arshed A. Quyyumi, Viola Vaccarino and J. Douglas Bremner

    Citation: Biology of Sex Differences 2019 10:35

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  15. Content type: Research

    Chronic inflammation and impaired sleep increase the risk for cardiovascular disease. Menopausal women may be particularly at risk as a result of impaired sleep. The objective of the current investigation was ...

    Authors: Bianca D’Antono and Véronique Bouchard

    Citation: Biology of Sex Differences 2019 10:34

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  16. Content type: Research

    Although some recent studies have indicated an association between metabolic syndrome (MetS) and musculoskeletal disease, little is known about the association of MetS with low back pain (LBP). The present stu...

    Authors: Takahiko Yoshimoto, Hirotaka Ochiai, Takako Shirasawa, Satsue Nagahama, Akihito Uehara, Shogo Sai and Akatsuki Kokaze

    Citation: Biology of Sex Differences 2019 10:33

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  17. Content type: Research

    Studies assessing volumetric sex differences have provided contradictory results. Total intracranial volume (TIV) is a major confounding factor when estimating local volumes of interest (VOIs). We investigated...

    Authors: Carla Sanchis-Segura, Maria Victoria Ibañez-Gual, Jesús Adrián-Ventura, Naiara Aguirre, Álvaro Javier Gómez-Cruz, César Avila and Cristina Forn

    Citation: Biology of Sex Differences 2019 10:32

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  18. Content type: Review

    It is well documented that the metabolic syndrome predisposes patients to increased cardiovascular risk. Emerging data indicates that cardiovascular risk conferred by metabolic syndrome is highly dependent on ...

    Authors: Jessica L. Faulkner and Eric J. Belin de Chantemèle

    Citation: Biology of Sex Differences 2019 10:30

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  19. Content type: Review

    Key differences exist between men and women in the determinants and manifestations of cardiovascular and cardiometabolic diseases. Recently, gut microbiome-host relations have been implicated in cardiovascular...

    Authors: Alexander C. Razavi, Kaitlin S. Potts, Tanika N. Kelly and Lydia A. Bazzano

    Citation: Biology of Sex Differences 2019 10:29

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  20. Content type: Research

    There are sex differences in risk for stroke and small vessel ischemic disease in the brain. Microvesicles (MV) derived from activated cells vary by cell of origin and the stimulus initiating their release. MV...

    Authors: Larry W. Hunter, Muthuvel Jayachandran and Virginia M. Miller

    Citation: Biology of Sex Differences 2019 10:26

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  21. Content type: Review

    Adipocytes and macrophages, the two major constituents of adipose tissue, exhibit sex differences and work in synergy in adipose tissue physiology and pathophysiology, including obesity-linked insulin resistan...

    Authors: Yang Xin Zi Xu, Geetika Bassi and Suresh Mishra

    Citation: Biology of Sex Differences 2019 10:25

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  22. Content type: Research

    African Americans (AA) develop hypertension (HTN) at an earlier age, have a greater frequency and severity of HTN, and greater prevalence of uncontrolled HTN as compared to the white population. Mineralocortic...

    Authors: John S. Clemmer, Jessica L. Faulkner, Alex J. Mullen, Kenneth R. Butler and Robert L. Hester

    Citation: Biology of Sex Differences 2019 10:24

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  23. Content type: Research

    Knee osteoarthritis (OA) is among the most common and disabling persistent pain conditions, with increasing prevalence in the developed world, and affects women to a greater degree than men. In the USA, the gr...

    Authors: Meghna Nandi, Kristin L. Schreiber, Marc O. Martel, Marise Cornelius, Claudia M. Campbell, Jennifer A. Haythornthwaite, Michael T. Smith Jr., John Wright, Linda S. Aglio, Gary Strichartz and Robert R. Edwards

    Citation: Biology of Sex Differences 2019 10:23

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  24. Content type: Research

    Exposure to an adverse environment in early life can have lifelong consequences for risk of cardiovascular disease. Maternal alcohol (ethanol) intake is common and associated with a variety of harmful effects ...

    Authors: Sarah L. Walton, Melissa Tjongue, Marianne Tare, Edmund Kwok, Megan Probyn, Helena C. Parkington, John F. Bertram, Karen M. Moritz and Kate M. Denton

    Citation: Biology of Sex Differences 2019 10:21

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  25. Content type: Research

    Antarctica challenges human explorers by its extreme environment. The effects of these unique conditions on the human physiology need to be understood to best mitigate health problems in Antarctic expedition c...

    Authors: C. Strewe, D. Moser, J.-I. Buchheim, H.-C. Gunga, A. Stahn, B. E. Crucian, B. Fiedel, H. Bauer, P. Gössmann-Lang, D. Thieme, E. Kohlberg, A. Choukèr and M. Feuerecker

    Citation: Biology of Sex Differences 2019 10:20

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  26. Content type: Research

    The obesity-related risk of developing metabolic syndrome is higher in males than in females of reproductive age, likely due to estrogen-mediated reduced adipose tissue inflammation and fibrosis with hypertrop...

    Authors: Sujoy Ghosh, Jessica L. Taylor, Tamra M. Mendoza, Thanh Dang, David H. Burk, Yongmei Yu, Gail Kilroy and Z. Elizabeth Floyd

    Citation: Biology of Sex Differences 2019 10:19

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    The Correction to this article has been published in Biology of Sex Differences 2019 10:38

  27. Content type: Correction

    .

    Authors: Parisa Amiri, Golnaz Vahedi-Notash, Parisa Naseri, Davood Khalili, Seyed Saeed Hashemi Nazari, Yadollah Mehrabi, Ali Reza Mahdavi Hazaveh, Fereidoun Azizi and Farzad Hadaegh

    Citation: Biology of Sex Differences 2019 10:18

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    The original article was published in Biology of Sex Differences 2019 10:15

  28. Content type: Research

    Weight loss by surgery or lifestyle changes is strongly recommended for obese individuals to improve metabolic health, but the underlying impairments that persist from a history of obesity remain unclear. Rece...

    Authors: Cameron Griffin, Chelsea R. Hutch, Simin Abrishami, Daria Stelmak, Leila Eter, Ziru Li, Eric Chang, Devyani Agarwal, Brian Zamarron, Mita Varghese, Perla Subbaiah, Ormond A. MacDougald, Darleen A. Sandoval and Kanakadurga Singer

    Citation: Biology of Sex Differences 2019 10:16

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  29. Content type: Research

    The current nationwide study, for the first time, aimed to assess and compare the trend of pre-hypertension and hypertension among urban and rural adolescents in Iran.

    Authors: Parisa Amiri, Golnaz Vahedi-Notash, Parisa Naseri, Davood Khalili, Seyed Saeed Hashemi Nazari, Yadollah Mehrabi, Ali Reza Mahdavi Hazaveh, Fereidoun Azizi and Farzad Hadaegh

    Citation: Biology of Sex Differences 2019 10:15

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    The Correction to this article has been published in Biology of Sex Differences 2019 10:18

  30. Content type: Research

    Postoperative cognitive dysfunction (POCD) is a common postoperative complication experienced by patients aged 65 years and older, and these older adults comprise more than one third of the surgical patients i...

    Authors: Katie J. Schenning, Charles F. Murchison, Nora C. Mattek, Jeffrey A. Kaye and Joseph F. Quinn

    Citation: Biology of Sex Differences 2019 10:14

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  31. Content type: Research

    The male predominance in the incidence of nasopharyngeal carcinoma (NPC) suggests the contribution of the X chromosome to the susceptibility of NPC. However, no X-linked susceptibility loci have been examined ...

    Authors: Xiao-Yu Zuo, Qi-Sheng Feng, Jian Sun, Pan-Pan Wei, Yoon-Ming Chin, Yun-Miao Guo, Yun-Fei Xia, Bo Li, Xiao-Jun Xia, Wei-Hua Jia, Jian-Jun Liu, Alan Soo-Beng Khoo, Taisei Mushiroda, Ching-Ching Ng, Wen-Hui Su, Yi-Xin Zeng…

    Citation: Biology of Sex Differences 2019 10:13

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  32. Content type: Research

    The response to overfeeding is sex dependent, and metabolic syndrome is more likely associated to obesity in men or postmenopausal women than in young fertile women. We hypothesized that obesity-induced metabo...

    Authors: Marcela González-Granillo, Luisa A. Helguero, Eliana Alves, Amena Archer, Christina Savva, Matteo Pedrelli, Osman Ahmed, Xidan Li, Maria Rosário Domingues, Paolo Parini, Jan-Åke Gustafsson and Marion Korach-André

    Citation: Biology of Sex Differences 2019 10:11

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  33. Content type: Correction

    Following publication of the original article [1], we noticed a number of errors.

    Authors: Katsuya Uchida, Hiroko Otsuka, Masahiro Morishita, Shinji Tsukahara, Tatsuya Sato, Kenji Sakimura and Keiichi Itoi

    Citation: Biology of Sex Differences 2019 10:10

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    The original article was published in Biology of Sex Differences 2019 10:6

  34. Content type: Research

    Orphanin FQ (aka nociceptin; N/OFQ) binds to its nociceptin opioid peptide (NOP) receptor expressed in proopiomelanocortin (POMC) neurons within the arcuate nucleus (ARC), a critical anorexigenic component of ...

    Authors: Jennifer Hernandez, Carolina Fabelo, Lynnea Perez, Clare Moore, Rachel Chang and Edward J. Wagner

    Citation: Biology of Sex Differences 2019 10:9

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  35. Content type: Research

    Maladaptive remodeling in pressure overload (PO)-induced left ventricular hypertrophy (LVH) may lead to heart failure. Major sex differences have been reported in this process. The steroid hormone 17β-estradio...

    Authors: Hugo Sanchez-Ruderisch, Ana Maria Queirós, Daniela Fliegner, Claudia Eschen, Georgios Kararigas and Vera Regitz-Zagrosek

    Citation: Biology of Sex Differences 2019 10:8

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  36. Content type: Review

    Cardiovascular diseases (CVDs) culminating into heart failure (HF) are major causes of death in men and women. Prevalence and manifestation, however, differ between sexes, since men mainly present with coronar...

    Authors: Elise L. Kessler, Mathilde R. Rivaud, Marc A. Vos and Toon A. B. van Veen

    Citation: Biology of Sex Differences 2019 10:7

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  37. Content type: Research

    The bed nucleus of the stria terminalis (BNST) contains the highest density of corticotropin-releasing factor (CRF)-producing neurons in the brain. CRF-immunoreactive neurons show a female-biased sexual dimorp...

    Authors: Katsuya Uchida, Hiroko Otsuka, Masahiro Morishita, Shinji Tsukahara, Tatsuya Sato, Kenji Sakimura and Keiichi Itoi

    Citation: Biology of Sex Differences 2019 10:6

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    The Correction to this article has been published in Biology of Sex Differences 2019 10:10

  38. Content type: Research

    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the nervous system. Previous studies have shown fluctuations in expression levels of GABA signaling components—glutamic acid decarbo...

    Authors: Madhavi Pandya, Thulani H. Palpagama, Clinton Turner, Henry J. Waldvogel, Richard L. Faull and Andrea Kwakowsky

    Citation: Biology of Sex Differences 2019 10:5

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  39. Content type: Research

    Estrogen is formed by the enzyme aromatase (CYP19A1) and signals via three identified receptors ERα (ESR1), ERß (ESR2), and the G protein-coupled estrogen receptor (GPER). Understanding the relative contributi...

    Authors: Dillion D. Hutson, Rakesh Gurrala, Benard O. Ogola, Margaret A. Zimmerman, Ricardo Mostany, Ryousuke Satou and Sarah H. Lindsey

    Citation: Biology of Sex Differences 2019 10:4

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  40. Content type: Commentary

    The Fast-Track Action Committee on (the) Health Science and Technology Response to the Opioid Crisis recently released their draft report for public comment. This report provides the “roadmap” for a coordinate...

    Authors: Jill B. Becker and Carolyn M. Mazure

    Citation: Biology of Sex Differences 2019 10:3

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  41. Content type: Research

    Men are at higher risk of developing chronic lymphocytic leukemia (CLL) than women. DNA methylation has been shown to play important roles in a number of cancers. There are differences in the DNA methylation p...

    Authors: Shuchun Lin, Yun Liu, Lynn R. Goldin, Chen Lyu, Xiangyin Kong, Yan Zhang, Neil E. Caporaso, Song Xiang and Ying Gao

    Citation: Biology of Sex Differences 2019 10:2

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  42. Content type: Research

    The pathogenesis of hypertension is distinct between men and women. Endothelin-1 (ET-1) is a potential contributor to sex differences in the pathophysiology of hypertension. ET-1 participates in blood pressure...

    Authors: Eman Y. Gohar, Anthony K. Cook, David M. Pollock and Edward W. Inscho

    Citation: Biology of Sex Differences 2019 10:1

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  43. Content type: Research

    Atherosclerotic lesions are comprised of distinct regions with different proteomic profiles. Men and women develop differences in lesion phenotype, with lesions from women generally being more stable and less ...

    Authors: Liam J. Ward, Patrik Olausson, Wei Li and Xi-Ming Yuan

    Citation: Biology of Sex Differences 2018 9:54

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