Articles
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Citation: Biology of Sex Differences 2023 14:42
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Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
The development and persistence of addiction is mediated in part by drug-induced alterations in nucleus accumbens (NAc) function. AMPA-type glutamate receptors (AMPARs) provide the main source of excitatory dr...
Citation: Biology of Sex Differences 2023 14:41 -
Are we moving the dial? Canadian health research funding trends for women’s health, 2S/LGBTQ + health, sex, or gender considerations
Sex and gender impacts health outcomes and disease risk throughout life. The health of women and members of the Two-Spirit, Lesbian, Gay, Bisexual, Transgender, Queer or Questioning (2S/LGBTQ +) community is o...
Citation: Biology of Sex Differences 2023 14:40 -
Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study
This study investigated the effect of sex and age at type 2 diabetes (T2D) diagnosis on the influence of T2D-related genes, parental history of T2D, and obesity on T2D development.
Citation: Biology of Sex Differences 2023 14:39 -
Sex hormones influence survival of patients with metastatic urothelial carcinoma undergoing immune checkpoint therapy
Clinical trials investigating efficacy of immune checkpoint inhibitors (ICI) revealed sex-specific divergent outcomes in urothelial cancer (UC), suggesting that sex hormones might play an important role in gen...
Citation: Biology of Sex Differences 2023 14:38 -
Breast cancer: the first comparative evaluation of oncobiome composition between males and females
Emerging evidence suggests that breast microbiota dysbiosis contributes to cancer initiation, progression, prognosis and treatment efficacy. Anyway, available data are referred only to female patients, and stu...
Citation: Biology of Sex Differences 2023 14:37 -
Integrated analysis of robust sex-biased gene signatures in human brain
Sexual dimorphism is highly prominent in mammals with many physiological and behavioral differences between male and female form of the species. Accordingly, the fundamental social and cultural stratification ...
Citation: Biology of Sex Differences 2023 14:36 -
Sex-specific associations of matrix metalloproteinases in Alzheimer’s disease
Alzheimer’s disease (AD) can be characterised in vivo by biomarkers reflecting amyloid-β (Aβ) and tau pathology. However, there is a need for biomarkers reflecting additional pathological pathways. Matrix meta...
Citation: Biology of Sex Differences 2023 14:35 -
Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia
The vast majority of women with dementia are post-menopausal. Despite clinical relevance, menopause is underrepresented in rodent models of dementia. Before menopause, women are less likely than men to experie...
Citation: Biology of Sex Differences 2023 14:34 -
Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats
Sex differences play a critical role in the incidence and severity of cardiovascular diseases, whereby men are at a higher risk of developing cardiovascular disease compared to age-matched premenopausal women....
Citation: Biology of Sex Differences 2023 14:33 -
Sex differences in cardiovascular risk, lifestyle, and psychological factors in patients with type 2 diabetes: the Fukuoka Diabetes Registry
The excess risk of cardiovascular diseases associated with diabetes is greater in women than in men. The present study aimed to examine sex differences in the control of cardiovascular risk factors, as well as...
Citation: Biology of Sex Differences 2023 14:32 -
Sex differences in the effects of high fat diet on underlying neuropathology in a mouse model of VCID
Damage to the cerebral vasculature can lead to vascular contributions to cognitive impairment and dementia (VCID). A reduction in blood flow to the brain leads to neuropathology, including neuroinflammation an...
Citation: Biology of Sex Differences 2023 14:31 -
Comparative developmental genomics of sex-biased gene expression in early embryogenesis across mammals
Mammalian gonadal sex is determined by the presence or absence of a Y chromosome and the subsequent production of sex hormones contributes to secondary sexual differentiation. However, sex chromosome-linked ge...
Citation: Biology of Sex Differences 2023 14:30 -
Sex-based differences in cardiovascular proteomic profiles and their associations with adverse outcomes in patients with chronic heart failure
Studies focusing on sex differences in circulating proteins in patients with heart failure with reduced ejection fraction (HFrEF) are scarce. Insight into sex-specific cardiovascular protein profiles and their...
Citation: Biology of Sex Differences 2023 14:29 -
Sex and gender differences in drug treatment: experiences from the knowledge database Janusmed Sex and Gender
Evidence from clinical research indicates that men and women can differ in response to drug treatment. The knowledge database Janusmed Sex and Gender was developed to illuminate potential sex and gender differ...
Citation: Biology of Sex Differences 2023 14:28 -
Higher testosterone is associated with open-angle glaucoma in women: a genetic predisposition?
Testosterone may be a possible modifiable risk factor for open-angle glaucoma (OAG) and intraocular pressure (IOP), but evidence has been scarce and conflicting. In this study we evaluated the association of t...
Citation: Biology of Sex Differences 2023 14:27 -
Moderating effects of uric acid and sex on cognition and psychiatric symptoms in asymmetric Parkinson’s disease
Non-motor symptoms are an important early feature of Parkinson’s disease (PD), encompassing a variety of cognitive and psychiatric symptoms that seem to manifest differently depending on motor symptom asymmetr...
Citation: Biology of Sex Differences 2023 14:26 -
Sex differences in learning and performing the Go/NoGo tasks
The quality of learning and post-learning performances is critical for daily life. The behavioral flexibility is equally important for adapting the changing circumstances. The learning process requires repeate...
Citation: Biology of Sex Differences 2023 14:25 -
Neurobehavioral sex-related differences in Nf1+/− mice: female show a “camouflaging”-type behavior
Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). This condition has been associated with an increase...
Citation: Biology of Sex Differences 2023 14:24 -
Prospective paired crossover evaluation of potential impact of investigator gender on perceived pain intensity early after acute or scheduled surgery
Postoperative pain is common but often difficult to assess, and there are many potential confounders. Over the last decades, the gender of investigator as well as participant has been found to influence pain p...
Citation: Biology of Sex Differences 2023 14:23 -
Lipidomic landscape of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxication: a sex difference study
Lipids represent essential components of extracellular vesicles (EVs), playing structural and regulatory functions during EV biogenesis, release, targeting, and cell uptake. Importantly, lipidic dysregulation ...
Citation: Biology of Sex Differences 2023 14:22 -
Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism and masculinization of intermediate metabolism in women with polycystic ovary syndrome (PCOS)
The polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiometabolic comorbidities. We here challenged the hypothesis, using state-of-the art proton nuclear magnetic resonanc...
Citation: Biology of Sex Differences 2023 14:21 -
Deciphering the sex bias in housekeeping gene expression in adipose tissue: a comprehensive meta-analysis of transcriptomic studies
As the housekeeping genes (HKG) generally involved in maintaining essential cell functions are typically assumed to exhibit constant expression levels across cell types, they are commonly employed as internal ...
Citation: Biology of Sex Differences 2023 14:20 -
Sex differences in the transcriptome of extracellular vesicles secreted by fetal neural stem cells and effects of chronic alcohol exposure
Prenatal alcohol (ethanol) exposure (PAE) results in brain growth restriction, in part, by reprogramming self-renewal and maturation of fetal neural stem cells (NSCs) during neurogenesis. We recently showed th...
Citation: Biology of Sex Differences 2023 14:19 -
Correction: Sex differences in fetal intracranial volumes assessed by in utero MR imaging
Citation: Biology of Sex Differences 2023 14:18 -
Sex-dependent variation in cartilage adaptation: from degeneration to regeneration
Despite acknowledgement in the scientific community of sex-based differences in cartilage biology, the implications for study design remain unclear, with many studies continuing to arbitrarily assign demograph...
Citation: Biology of Sex Differences 2023 14:17 -
Aerobic exercise improves executive functions in females, but not males, without the BDNF Val66Met polymorphism
Aerobic exercise promotes cognitive function in older adults; however, variability exists in the degree of benefit. The brain-derived neurotropic factor (BDNF) Val66Met polymorphism and biological sex are biol...
Citation: Biology of Sex Differences 2023 14:16 -
Effects of 5α-dihydrotestosterone on the modulation of monocyte/macrophage response to Staphylococcus aureus: an in vitro study
Staphylococcus aureus (S. aureus) is a pathogen responsible for a wide range of clinical manifestations and potentially fatal conditions. There is a paucity of information on the influence of androgens in the imm...
Citation: Biology of Sex Differences 2023 14:15 -
CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Fatty acid metabolism in the hypothalamus has an important role in food intake, but its specific role in AgRP neurons is poorly understood. Here, we examined whether carnitinea palmitoyltransferase 1A (CPT1A),...
Citation: Biology of Sex Differences 2023 14:14 -
Sex differences in fetal intracranial volumes assessed by in utero MR imaging
The primary aim of the study is to test the null hypothesis that there are no statistically significant differences in intracranial volumes between male and female fetuses. Furthermore, we have studied the sym...
Citation: Biology of Sex Differences 2023 14:13 -
Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort
Obesity is accompanied by low-grade inflammation and leucocytosis and increases the risk of venous thromboembolism. Associations with platelet count, however, are unclear, because several studies have reported...
Citation: Biology of Sex Differences 2023 14:12 -
Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans
The clinical course and outcome of many diseases differ between women and men, with women experiencing a higher prevalence and more severe pathogenesis of autoimmune diseases. The precise mechanisms underlying...
Citation: Biology of Sex Differences 2023 14:11 -
Sex differences in hearing impairment due to diet-induced obesity in CBA/Ca mice
Obesity is an independent risk factor for hearing loss. Although attention has focused on major obesity comorbidities such as cardiovascular disease, stroke, and type 2 diabetes, the impact of obesity on senso...
Citation: Biology of Sex Differences 2023 14:10 -
Sex-specific associations between diabetes and dementia: the role of age at onset of disease, insulin use and complications
Whether the association of type 2 diabetes (T2DM) with dementia was differed by sex remains unclear, and the roles of age at onset of disease, insulin use and diabetes’ complications in their association are u...
Citation: Biology of Sex Differences 2023 14:9 -
Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus
Bisphenol A (BPA) has been linked to susceptibility to autism spectrum disorder (ASD). Our recent studies have shown that prenatal BPA exposure disrupted ASD-related gene expression in the hippocampus, neurolo...
Citation: Biology of Sex Differences 2023 14:8 -
Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner
The mechanisms by which parental early life stress can be transmitted to the next generation, in some cases in a sex-specific manner, are unclear. Maternal preconception stress may increase susceptibility to s...
Citation: Biology of Sex Differences 2023 14:7 -
Sex differences in subjective cognitive impairment and clinical correlates in Chinese patients with subthreshold depression
Subthreshold depression (SD) is a global mental health problem given its high prevalence, comorbidity, functional impairment, and its association with increased service utilization. However, currently little i...
Citation: Biology of Sex Differences 2023 14:6 -
Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases
Smell impairment is one of the earliest features in Alzheimer’s (AD) and Parkinson’s diseases (PD). Due to sex differences exist in terms of smell and olfactory structures as well as in the prevalence and mani...
Citation: Biology of Sex Differences 2023 14:5 -
Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases
Metabolic diseases, such as obesity, metabolic syndrome (MetS) and type 2 diabetes (T2D), are now a widespread pandemic in the developed world. These pathologies show sex differences in their development and p...
Citation: Biology of Sex Differences 2023 14:4 -
Monkeys do not show sex differences in toy preferences through their individual choices
As interest in evaluating sex differences in nonhuman animals grows, the finding that male and female monkeys have toy preferences that differ, and that parallel those documented in human children, has garnere...
Citation: Biology of Sex Differences 2023 14:3 -
Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance
Asthma is a chronic airway condition that occurs more often in women than men during reproductive years. Population studies have collectively shown that long-term use of oral contraceptives decreased the onset...
Citation: Biology of Sex Differences 2023 14:2 -
Chronic periadolescent leuprolide exposure affects the development of reproductive physiology and behavior of female and male rats differently, but both mature after treatment termination
GnRH agonists have been used to halt the development of puberty in children with precocious puberty since the 1980s. Recently, drugs like Lupron Depot® (leuprolide acetate), have been used to suppress pubertal pr...
Citation: Biology of Sex Differences 2023 14:1 -
A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala
Dopaminergic circuits play important roles in the motivational control of behavior and dysfunction in dopaminergic circuits have been implicated in several psychiatric disorders, such as schizophrenia and depr...
Citation: Biology of Sex Differences 2022 13:75 -
Sex differences in early and term placenta are conserved in adult tissues
Pregnancy complications vary based on the fetus’s genetic sex, which may, in part, be modulated by the placenta. Furthermore, developmental differences early in life can have lifelong health outcomes. Yet, sex...
Citation: Biology of Sex Differences 2022 13:74 -
Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fish, Monopterus albus
Monopterus albus is a hermaphroditic and economically farmed fish that undergoes sex reversal from ovary to testis via ovotestis during gonadal development. The epigenetic changes that are associated with gonadal...
Citation: Biology of Sex Differences 2022 13:73 -
High pulse pressure is associated with an increased risk of diabetes in females but not in males: a retrospective cohort study
Accumulating evidence suggests a close relationship between metabolic disturbance and increased arterial stiffness. However, whether there is an association between pulse pressure (PP) and diabetes and how thi...
Citation: Biology of Sex Differences 2022 13:72 -
Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis
Accumulating evidence suggest the existence of sex-related differences in the pathogenesis of aortic stenosis (AS) with inflammation, oxidative stress, fibrosis and calcification being over-represented in men....
Citation: Biology of Sex Differences 2022 13:71 -
Plasma TIMP-1 as a sex-specific biomarker for acute lung injury
Acute respiratory distress syndrome (ARDS) confers high morbidity and mortality, with a death rate reaching 40%. Pre-clinical and clinical studies have cited sex-specific sex hormones as a critical contributor...
Citation: Biology of Sex Differences 2022 13:70 -
Dynamic transcriptome analysis reveals the gene network of gonadal development from the early history life stages in dwarf surfclam Mulinia lateralis
Gonadal development is driven by a complex genetic cascade in vertebrates. However, related information remains limited in molluscs owing to the long generation time and the difficulty in maintaining whole lif...
Citation: Biology of Sex Differences 2022 13:69 -
Unveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies
In recent decades, increasing longevity (among other factors) has fostered a rise in Parkinson's disease incidence. Although not exhaustively studied in this devastating disease, the impact of sex represents a...
Citation: Biology of Sex Differences 2022 13:68