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Biology of Sex Differences

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  1. Content type: Research

    Postpartum depression affects approximately 15% of mothers and represents a form of early life adversity for developing offspring. Postpartum depression can be treated with prescription antidepressants like fl...

    Authors: Aarthi R. Gobinath, Joanna L. Workman, Carmen Chow, Stephanie E. Lieblich and Liisa A. M. Galea

    Citation: Biology of Sex Differences 2017 8:20

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  2. Content type: Research

    Apoe-deficient (Apoe −/−) mice develop progressive atherosclerotic lesions with age but no severe renal pathology in the absence of additional challenges. We...

    Authors: Ines Marek, Maurizio Canu, Nada Cordasic, Manfred Rauh, Gudrun Volkert, Fabian B. Fahlbusch, Wolfgang Rascher, Karl F. Hilgers, Andrea Hartner and Carlos Menendez-Castro

    Citation: Biology of Sex Differences 2017 8:19

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  3. Content type: Research

    A more severe disease phenotype has been reported in men compared to women in several rheumatic diseases. However, studies have not conclusively established sex-related clinical features in primary Sjögren’s s...

    Authors: Jorge I. Ramírez Sepúlveda, Marika Kvarnström, Susanna Brauner, Chiara Baldini and Marie Wahren-Herlenius

    Citation: Biology of Sex Differences 2017 8:16

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  4. Content type: Commentary

    Science has come a long way with regard to the consideration of sex differences in clinical and preclinical research, but one field remains behind the curve: human statistical genetics. The goal of this commen...

    Authors: Matthew S. Powers, Phillip H. Smith, Sherry A. McKee and Marissa A. Ehringer

    Citation: Biology of Sex Differences 2017 8:15

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  5. Content type: Research

    The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on a...

    Authors: Leonie H. Bogl, Aline Jelenkovic, Eero Vuoksimaa, Linda Ahrenfeldt, Kirsi H. Pietiläinen, Maria A. Stazi, Corrado Fagnani, Cristina D’Ippolito, Yoon-Mi Hur, Hoe-Uk Jeong, Judy L. Silberg, Lindon J. Eaves, Hermine H. Maes, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Tessa L. Cutler…

    Citation: Biology of Sex Differences 2017 8:14

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  6. Content type: Research

    Cardiovascular disease varies between sexes, suggesting male-female autonomic control differences. Insular gyri help coordinate autonomic regulation and show a sex-dependent response to a sympathetic challenge.

    Authors: Paul M. Macey, Nicholas S. Rieken, Jennifer A. Ogren, Katherine E. Macey, Rajesh Kumar and Ronald M. Harper

    Citation: Biology of Sex Differences 2017 8:13

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  7. Content type: Research

    Optimal function of the abdominal muscles is necessary for several life functions including lifting and carrying tasks. Sex differences in strength and fatigability are established for many limb muscles and ba...

    Authors: Rita E. Deering, Jonathon W. Senefeld, Tatyana Pashibin, Donald A. Neumann and Sandra K. Hunter

    Citation: Biology of Sex Differences 2017 8:12

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  8. Content type: Research

    Studies investigating the influence of perinatal hormone exposure on sexually differentiated traits would greatly benefit from biomarkers of these early hormone actions. Click-evoked otoacoustic emissions show...

    Authors: Judy van Hemmen, Peggy T. Cohen-Kettenis, Thomas D. Steensma, Dick J. Veltman and Julie Bakker

    Citation: Biology of Sex Differences 2017 8:11

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  9. Content type: Research

    Cannabis will soon become legalized in Canada, and it is currently unclear how this will impact public health. Methadone maintenance treatment (MMT) is the most common pharmacological treatment for opioid use ...

    Authors: Laura Zielinski, Meha Bhatt, Nitika Sanger, Carolyn Plater, Andrew Worster, Michael Varenbut, Jeff Daiter, Guillaume Pare, David C. Marsh, Dipika Desai, James MacKillop, Meir Steiner, Stephanie McDermid Vaz, Lehana Thabane and Zainab Samaan

    Citation: Biology of Sex Differences 2017 8:8

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  10. Content type: Research

    There are differences in the prevalence and severity of diseases between males, females not taking hormonal contraceptives (non-HC females) and females taking hormonal contraceptives (HC females). The aim of t...

    Authors: Sebastian Rauschert, Olaf Uhl, Berthold Koletzko, Trevor A. Mori, Lawrence J. Beilin, Wendy H. Oddy and Christian Hellmuth

    Citation: Biology of Sex Differences 2017 8:10

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  11. Content type: Research

    Apolipoprotein E (ApoE) is a multifunctional protein, and its deficiency leads to the development of atherosclerosis in mice. Patients with pulmonary hypertension (PH) have reduced expression of ApoE in lung t...

    Authors: Soban Umar, Rod Partow-Navid, Gregoire Ruffenach, Andrea Iorga, Shayan Moazeni and Mansoureh Eghbali

    Citation: Biology of Sex Differences 2017 8:9

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  12. Content type: Research

    Females are markedly underinvestigated in the biological and behavioral sciences due to the presumption that cyclic hormonal changes across the ovulatory cycle introduce excess variability to measures of inter...

    Authors: Benjamin L. Smarr, Azure D. Grant, Irving Zucker, Brian J. Prendergast and Lance J. Kriegsfeld

    Citation: Biology of Sex Differences 2017 8:7

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  13. Content type: Research

    Physiological factors such as age and sex have been shown to be risk factors for adverse effects in the liver, including liver diseases and drug-induced liver injury. Previously, we have reported age- and sex-...

    Authors: Joshua C. Kwekel, Vikrant Vijay, Tao Han, Carrie L. Moland, Varsha G. Desai and James C. Fuscoe

    Citation: Biology of Sex Differences 2017 8:6

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  14. Content type: Research

    Serum peptidases, such as angiotensin-converting enzyme (ACE), angiotensin-converting enzyme-2 (ACE2), neutral endopeptidase (NEP), aminopeptidase N (APN), and aminopeptidase A (APA), are important elements of...

    Authors: A. Fernández-Atucha, A. Izagirre, A. B. Fraile-Bermúdez, M. Kortajarena, G. Larrinaga, P. Martinez-Lage, E Echevarría and J. Gil

    Citation: Biology of Sex Differences 2017 8:5

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  15. Content type: Research

    Eighty percent of patients who receive bariatric surgery are women, yet the majority of preclinical studies are in male rodents. Because sex differences drive hepatic gene expression and overall lipid metaboli...

    Authors: Bernadette E. Grayson, Ruth Gutierrez-Aguilar, Joyce E. Sorrell, Emily K. Matter, Michelle R. Adams, Philip Howles, Rebekah Karns, Randy J. Seeley and Darleen A. Sandoval

    Citation: Biology of Sex Differences 2017 8:4

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  16. Content type: Review

    Gender-specific differences in hypothalamus–pituitary–adrenal (HPA) axis activity have been postulated to emerge during puberty. We conducted a systematic review and meta-analysis to test the hypothesis that g...

    Authors: Bibian van der Voorn, Jonneke J. Hollanders, Johannes C. F. Ket, Joost Rotteveel and Martijn J. J. Finken

    Citation: Biology of Sex Differences 2017 8:3

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  17. Content type: Research

    Corticotropin-releasing factor overexpressing (CRF-OE) male mice showed an inhibited feeding response to a fast, and lower plasma acyl ghrelin and Fos expression in the arcuate nucleus compared to wild-type (W...

    Authors: Lixin Wang, Miriam Goebel-Stengel, Pu-Qing Yuan, Andreas Stengel and Yvette Taché

    Citation: Biology of Sex Differences 2017 8:2

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  18. Content type: Research

    There is inconclusive evidence about the role of sex as a risk factor for doxorubicin (DOX)-induced cardiotoxicity. Recent experimental studies have shown that adult female rats are protected against DOX-induc...

    Authors: Marianne K. O. Grant, Davis M. Seelig, Leslie C. Sharkey and Beshay N. Zordoky

    Citation: Biology of Sex Differences 2017 8:1

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  19. Content type: Review

    In animals with heteromorphic sex chromosomes, all sex differences originate from the sex chromosomes, which are the only factors that are consistently different in male and female zygotes. In mammals, the imb...

    Authors: Paul S. Burgoyne and Arthur P. Arnold

    Citation: Biology of Sex Differences 2016 7:68

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  20. Content type: Research

    The higher prevalence of obesity-related metabolic disease in males suggests that female sex hormones provide protective mechanisms against the pathogenesis of metabolic syndrome. Because browning of white adi...

    Authors: Sang-Nam Kim, Young-Suk Jung, Hyun-Jung Kwon, Je Kyung Seong, James G. Granneman and Yun-Hee Lee

    Citation: Biology of Sex Differences 2016 7:67

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  21. Content type: Research

    Lifestyle factors may influence the risk of developing pancreatic cancer. Whereas cigarette smoking is an established risk factor, the effects of high alcohol intake and obesity are more uncertain. The aim of ...

    Authors: Gustav Andersson, Christoffer Wennersten, Signe Borgquist and Karin Jirström

    Citation: Biology of Sex Differences 2016 7:66

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  22. Content type: Research

    Sexual dimorphism in blood pressure has been associated with differential expression of the angiotensin II (AII) receptors and with activity of the nervous system. It is generally accepted that ageing affects ...

    Authors: Wioletta Pijacka, Bethan Clifford, Dawid Walas, Chantal Tilburgs, Jaap A. Joles, Sarah McMullen and Simon C. Langley-Evans

    Citation: Biology of Sex Differences 2016 7:64

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