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Table 2 Differentially expressed circulating miRNAs in preeclampsia and their effects in heart disease

From: Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs

miRNARegulation in human pregnancyRef.Heart diseaseMechanism and outcomeRef.
miR-210-3p and
miR-210-5p
↑ serum[160,161,162,163]Hypoxic cardiomyocytes, mouse and rat↑ Akt → ↑ miR-210 → ↓ PDCD4 →
↓ ROS, ↓ cell death
[164, 165]
Mouse LAD ligation↑ miR-210-3p → ↓ APC → ↓ cardiomyocyte apoptosis, ↑ angiogenesis, ↑cardiac function[166]
Mouse LAD ligation↑ miR-210-3p in mesenchymal stem cells-derived extracellular vesicles → ↓ Efna3 → promote cardiac angiogenesis post-MI[167]
miR-29a↑ plasma[168]Patients with hypertrophic cardiomyopathy↑ miR-29a → ↑ cardiac hypertrophy, ↑fibrosis[169, 170]
Mouse TAC↓ miR-29a → ↓ cardiac hypertrophy, ↓fibrosis[170]
ET-1 in H9c2 cardiomyocytes↓ NFATc4 → ↓ cardiomyocyte hypertrophy[171]
miR-21↑ plasma[160]Mouse, cardiac fibroblast-derived exosomes↑ crosstalk between cardiac fibroblasts and cardiomyocytes → ↑ cardiomyocyte hypertrophy[172]
Mouse TACSpry1, ↑ ERK-MAPK activity →
↑ fibroblast survival, ↑ growth factor secretion → ↓ fibrosis, ↓ cardiac hypertrophy
[172]
Mouse post-MI via LAD ligation↓ SMAD7 → ↑ cardiac fibrosis post-MI[173]
Rat IRI↓ PDCD4 → ↓ apoptosis post-MI[174]
Mouse LAD ligation↓ miR-21 → targets KBTBD7 (p38 MAPK and NFκB modulator) → ↓ cardiac dysfunction/inflammatory signaling[175]
miR-155↑ plasma[160]miR-155-KO mice TAC↓ miR-155 → ↑ jumonji/Jarid2 →
↓ cardiac hypertrophy
[176]
miR-155 KO macrophages↑ Socs1 → ↑ cardiomyocyte hypertrophy[177]
fibroblast miR-155-KO↓ TP53INP1→ ↑ cardiac remodeling[178]
miR-206↑ plasma[179]Mouse with TAC-induced cardiac hypertrophy↑ miR-206 → ↓ tumor suppressor FoxP1→ ↑ TAC-induced cardiac hypertrophy[180]
miR-144↓ plasma and ↓ serum[160, 161, 168]miR-144-KO mouse LAD ligation↑ Zeb-1→ impaired fibrotic response post-injury → cardiac dysfunction[181]
Mouse LAD ligation↑ miR-144 mimic injection →
↓ fibrosis, ↓inflammation, ↓apoptosis → ↑cardiac function
[182]
miR-144-KO mouse↓ Rac-1 → ↑ ROS[183]
miR-125b-5p↓ plasma[184]Mouse LAD ligation↓ bak1, ↓ klf13 →
↓ cardiomyocyte apoptosis
[139]
miR-195-5p↓ plasma[184, 185]Severe PE patientsUnknown mechanismNA
↑ plasma[186]PE patients↑ sFLT1 levels[186]
Mouse Ang II infusion↑ miR-195-5p → ↓ FBXW7/MFN2 → ↑ mitochondrial membrane depolarization/ROS production →
↑ cardiomyocyte hypertrophy
[187]
miR-126↓ serum[161]miR-126-KO mice LCA ligation↑ Spred1 → defective angiogenesis[188]
Human cardiac microvascular endothelial cells↑ miR-126 → ↑ PI3K/Akt,
↑ VEGF, ↑SOD expression → hypoxia/reoxygenation injury protection
[189]
miR-204↓ serum[161]Mouse LAD ligation↑ miR-204 → ↓ LC3-II[190]
miR-15b↓ serum[161]Mouse TAC overload↑ miR-15b → ↓TGFβ signal(p38 MAPK/TGFβR-1 → ↑ cardiomyocyte hypertrophy, ↑ fibrosis[191]
  1. Akt protein kinase B, Ang II angiotensin II, APC adenomatous polyposis coli, ECM extracellular matrix, Efna3 angiogenesis modulator ephrin A3, ERK-MAPK extracellular signal-regulated kinases/mitogen-activated protein kinase, ET-1 endothelin 1, FBXW7 F-box and WD repeat domain containing 7, FoxP1 Forkhead box protein P1, IRI ischemia/reperfusion injury, Jarid2 jumonji, AT rich interactive domain 2, KBTBD7 kelch repeat and BTB domain-containing protein 7, KO knockout, LAD left anterior descending, LC3-II microtubule-associated protein 1 light chain 3, LC3-II microtubule-associated protein 1 light chain 3, LCA left coronary artery, MFN2 mitofusion 2, MI myocardial infarction, miR microRNA, NFATc4 nuclear factor of activated T cells 4, NFκB nuclear factor kappa-light-chain-enhancer of activated B cells, p38 MAPK mitogen activated protein kinase p38, PDCD4 programmed cell death protein 4, PE preeclampsia, PI3K/Akt phosphatidylinositol 3-kinase/protein kinase B, RAC-1 Ras-related C3 botulinum toxin substrate 1, ROS reactive oxygen species, sFLT1 fms-like tyrosine kinase 1, SMAD7 small mothers against decapentaplegic 7, Socs1 cytokine signaling 1, SOD superoxide dismutase, Spry1 sprouty RTK signaling antagonist 1, TAC transverse aortic constriction, TGFβR-1 transforming growth factor beta receptor I, TP53INP1 tumor protein p-53-inducible nuclear protein 1, VEGF vascular endothelial growth factor, Zeb-1 zinc finger E-box binding homeobox 1