Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs

Aryan, Laila; Medzikovic, Lejla; Umar, Soban; Eghbali, Mansoureh

doi:10.1186/s13293-020-00292-w

Biology of Sex Differences

Table 1 Differentially expressed circulating miRNAs in gestational diabetes mellitus and their effects in heart disease

From: Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs

miRNA	Regulation in human pregnancy	Ref.	Heart disease	Mechanism and outcome	Ref.
miR-125b-5p	↑ serum in first trimester, normalizes in second and third	[138]	Mouse LAD ligation	↓ bak1, ↓ klf13 → ↓ cardiomyocyte apoptosis	[139]
miR-183-5p	↑ serum, first trimester ↓ serum, third trimester	[138]	Rat cardiac IRI	↓ VDAC1 → ↓ apoptosis	[140]
miR-200b-3p	↑ serum, first trimester ↓ serum, third trimester	[138]	Mouse STZ-induced diabetic cardiomyopathy	↓ CD36, ↓ EndoMT → ↓ cardiac fibrosis ↓ cardiac dysfunction	[141, 142]
miR-21-3p	↑ plasma	[143, 144]	Mouse TAC and Ang II infusion	↓HDAC8 expression + Akt/Gsk3β signaling→ ↓ cardiac hypertrophy	[145]
miR-195-5p	↑ plasma	[146]	Mouse STZ-induced diabetic cardiomyopathy	↓ miR-195-5p → ↑ Bcl-2, ↑ sirtuin 1 → ↓ cardiac hypertrophy, ↓ ROS, ↓ apoptosis, ↑ myocardial capillary density, ↑coronary blood flow	[147]
miR-195-5p	↑ plasma	[146]	Rat cardiomyocytes	↓ miR-195-5p → ↑ SGK1 → rescues hERG potassium ion channel deficiency	[148]
miR-29a	↓ serum	[149]	Zucker diabetic fatty rats	↓ miR-29a → ↓ mcl-1	[150]
miR-29a	↓ serum	[149]	Rat myocardial cells stimulated with high glucose	↓ IGF-1 → ↑ apoptosis	[151]
miR-222	↓ serum	[149]	Mice with diabetic cardiomyopathy	↓ Wnt/ β-catenin signaling → ↓ EndoMT → ↓ cardiac fibrosis, ↑ cardiac function	[152]
			IRI in cardiomyocyte-specific miR-222 OE mice	↓ p27/HIPK1/Hmbox-1 → ↑ growth/proliferation, ↓ apoptosis	[152]
			miR-222 OE in mice	↓ p27 → ↑ mTOR signaling, ↓ autophagy → ↑ hypertrophy, ↑ fibrosis, ↑ dysfunction with age	[153]

Akt/Gsk3β protein kinase B/glycogen synthase kinase 3 beta, Ang II angiotensin II, bak1 Bcl2 homologous antagonist/killer, Bcl-2 B cell lymphoma 2, CD36 cluster of differentiation 36, EndoMT endothelial to mesenchymal transition, HDAC8 histone deacetylase 8, hERG human Ether-a-go-go-Related Gene, HIPK1 homeodomain interacting protein kinase 1, Hmbox-1 homeobox containing 1, I/R ischemia/reperfusion, IGF-1 insulin-like growth factor 1, IRI ischemia/reperfusion injury, klf13 kruppel-like factor 13, LAD left anterior descending, Mcl-1 myeloid cell leukemia 1, MI myocardial infarction, miR microRNA, mTOR mammalian target of rapamycin, OE overexpression, ROS reactive oxygen species, SGK1 serum/glucocorticoid regulated kinase 1, STZ streptozotocin, TAC transverse aortic constriction, VDAC1 voltage-dependent anion-selective channel 1, Wnt wingless-related integration site

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ISSN: 2042-6410

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