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Table 5 Effect of gonadectomy on Ca 2+ handling by the sarcoplasmic reticulum

From: Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms

Component Functional change Duration of GDX (weeks) Species Reference
SR Ca2+ release ↔ RyR2 protein 2 Rat [75]
a ↓ RyR-mediated 45Ca2+ flux 9 Rat [76]
SR Ca2ccps stores ↔ Calsequestrin protein 10-11 Mouse [69]
↔ Calreticulin protein 10-11 Mouse [69]
a↓ SR Ca2+ content 9 Rat [76]
SERCA2a ↔ SERCA2a protein 2 Rat [75]
10 Rat [96]
10-11 Mouse [69]
↔ SERCA activity 10 Rat [76]
  a↓ SERCA activity 9 Rat [96]
PLB ↔ PLB protein 2 Rat [75]
10 Rat [96]
9 Rat [76]
10-11 Mouse [69]
  a↓ PLB Thr17 phosphorylation 10-11 Mouse [69]
  10 Rat [96]
↓ PLB Ser16 phosphorylation 10-11 Mouse [69]
↔ PLB Ser16 phosphorylation 10 Rat [96]
  1. aIndicates that the effect of GDX was reversed by treatment with testosterone in studies by Tsang et al. [76] and Witayavanitkul et al. [96].