Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms

Table 2 Impact of chronic androgen treatment and GDX on resting and action potentials

^a Component	Treatment	Duration (weeks)	Preparation	Functional change	Species	Reference
Testosterone supplementation
RMP	^bTestosterone	4	Ventricular muscle	↔	Rat	[84]
RMP	^cDihydrotestosterone	13	Ventricular myocyte	↔	Mouse	[39]
AP amplitude	^bTestosterone	4	Ventricular muscle	↔	Rat	[84]
APD50	^bTestosterone	4	Ventricular muscle	↔	Rat	[84]
APD50	^cDihydrotestosterone	13	Ventricular myocyte	↓	Mouse	[39]
APD90/95	^bTestosterone	4	Ventricular muscle	↑	Rat	[84]
APD90/95	^cDihydrotestosterone	13	Ventricular myocyte	↓	Mouse	[39]
Gonadectomy (GDX)
RMP	GDX	4	Ventricular muscle	↔	Rat	[84]
RMP	GDX	11–15	Ventricular myocyte	↔	Mouse	[39]
AP amplitude	GDX	4	Ventricular muscle	↔	Rat	[84]
APD50	GDX	4	Ventricular muscle	↑	Rat	[84]
APD50	GDX	11–15	Ventricular myocyte	↑	Mouse	[39]
APD90/95	GDX	4	Ventricular muscle	↔	Rat	[84]
APD90/95	GDX	11–15	Ventricular myocyte	↑	Mouse	[39]

^aAll experiments used paced tissues and myocytes from male animals only. ^bTestosterone treatment with 5 mg/kg/day. ^cDihydrotestosterone treatment with a 7.5-mg pellet.

ISSN: 2042-6410