Table 1 Biological functions associated with differentially methylated genes in XX vs. XX + T mice determined by IPA
Category | Function annotation | Striatum | BNST/POA | ||
|---|---|---|---|---|---|
p value | Number of genes | p value | Number of genes | ||
Nervous system development and function | Morphology of nervous system | 1.02E − 08 | 108 | 3.91E − 06 | 63 |
Development of central nervous system | 6.63E − 08 | 80 | 4.71E − 08 | 54 | |
Morphology of nervous tissue | 7.88E − 06 | 72 | 7.75E − 05 | 44 | |
Neuritogenesis | 1.05E − 05 | 48 | 1.03E − 07 | 37 | |
Outgrowth of neurites | 4.68E − 05 | 39 | 2.19E − 03 | 22 | |
Coordination | 4.69E − 05 | 31 | 1.67E − 02 | 15 | |
Axonogenesis | 1.48E − 04 | 24 | 1.18E − 04 | 17 | |
Excitatory postsynaptic potential | 1.51E − 04 | 18 | 5.55E − 03 | 10 | |
Growth of neurites | 1.75E − 04 | 41 | 5.21E − 03 | 23 | |
Morphology of neurites | 7.77E − 04 | 23 | 1.99E − 04 | 17 | |
Morphology of dendritic spines | 7.78E − 04 | 5 | 7.85E − 04 | 4 | |
Guidance of axons | 9.29E − 04 | 21 | 1.60E − 05 | 18 | |
Outgrowth of axons | 9.56E − 04 | 14 | 9.82E − 03 | 8 | |
Neurotransmission | 6.32E − 05 | 44 | - | - | |
NMDA-mediated synaptic current | 2.93E − 04 | 6 | - | - | |
Action potential of cells | 3.58E − 04 | 18 | - | - | |
Long-term depression | 1.30E − 03 | 13 | - | - | |
Quantity of neurons | - | - | 3.81E − 05 | 24 | |
Cell viability of neurons | - | - | 1.93E − 02 | 12 | |
Cellular assembly and organization | Organization of cytoskeleton | 1.86E − 07 | 125 | 1.72E − 06 | 77 |
Microtubule dynamics | 2.17E − 07 | 108 | 7.64E − 06 | 65 | |
Skeletal and muscular system development and function | Development of muscle | 2.55E − 06 | 49 | - | - |
Cell death and survival | Apoptosis | 7.68E − 06 | 250 | 1.70E − 03 | 138 |
Cellular growth and proliferation | Proliferation of neuronal cells | - | - | 1.25E − 02 | 13 |
Behavior | Learning | 3.33E − 03 | 38 | 2.81E − 04 | 27 |
Social behavior | - | - | 2.59E − 03 | 7 | |