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Table 1 Biological functions associated with differentially methylated genes in XX vs. XX + T mice determined by IPA

From: The effects of perinatal testosterone exposure on the DNA methylome of the mouse brain are late-emerging

Category Function annotation Striatum BNST/POA
p value Number of genes p value Number of genes
Nervous system development and function Morphology of nervous system 1.02E − 08 108 3.91E − 06 63
Development of central nervous system 6.63E − 08 80 4.71E − 08 54
Morphology of nervous tissue 7.88E − 06 72 7.75E − 05 44
Neuritogenesis 1.05E − 05 48 1.03E − 07 37
Outgrowth of neurites 4.68E − 05 39 2.19E − 03 22
Coordination 4.69E − 05 31 1.67E − 02 15
Axonogenesis 1.48E − 04 24 1.18E − 04 17
Excitatory postsynaptic potential 1.51E − 04 18 5.55E − 03 10
Growth of neurites 1.75E − 04 41 5.21E − 03 23
Morphology of neurites 7.77E − 04 23 1.99E − 04 17
Morphology of dendritic spines 7.78E − 04 5 7.85E − 04 4
Guidance of axons 9.29E − 04 21 1.60E − 05 18
Outgrowth of axons 9.56E − 04 14 9.82E − 03 8
Neurotransmission 6.32E − 05 44 - -
NMDA-mediated synaptic current 2.93E − 04 6 - -
Action potential of cells 3.58E − 04 18 - -
Long-term depression 1.30E − 03 13 - -
Quantity of neurons - - 3.81E − 05 24
Cell viability of neurons - - 1.93E − 02 12
Cellular assembly and organization Organization of cytoskeleton 1.86E − 07 125 1.72E − 06 77
Microtubule dynamics 2.17E − 07 108 7.64E − 06 65
Skeletal and muscular system development and function Development of muscle 2.55E − 06 49 - -
Cell death and survival Apoptosis 7.68E − 06 250 1.70E − 03 138
Cellular growth and proliferation Proliferation of neuronal cells - - 1.25E − 02 13
Behavior Learning 3.33E − 03 38 2.81E − 04 27
Social behavior - - 2.59E − 03 7
  1. This table shows examples of functional categories enriched in the XX vs. XX + T comparison for both the striatum and BNST/POA.