Hormone Depletion
|
Gnx 3 mos
|
N/A
|
Intact vs Gnx
|
Gnx ↓ SAB (Y-maze)
[162, 163]
|
3xTg-AD
|
Gnx ↓ open arm time (EPM)
[164]
|
Gnx 3 mos
|
N/A
|
Intact vs Gnx
|
Gnx ↔ spatial memory (MWM)
[159]
|
APP+PS1
|
|
VCD 2-2.5 mos
|
N/A
|
Intact vs VCD
|
VCD ↔ spatial/working memory (RAWM)
[160]
|
APPswe
|
Estrogens
|
Gnx 3 mo
|
Immediate s.c. E2 (0.025 mg) 90 d
|
Gnx: Veh vs E2
|
E2 ↑ SAB (Y-maze)
[162, 164]
|
3xTg-AD
|
E2 ↓ freezing (FST)
[164]
|
Gnx 3 mos
|
Immediate s.c. PPT (0.25 mg) 90 d
|
Gnx: Veh vs PPT
|
PPT ↑ SAB (Y-maze)
[162]
|
3xTg-AD
|
Gnx 3 mos
|
Immediate s.c. DPN (0.25 mg) 90 d
|
Gnx: Veh vs DPN
|
DPN ↔ SAB (Y-maze)
[162]
|
3xTg-AD
|
Gnx 3 mos
|
Immediate, 3, & 6 mo later, s.c. E2 (0.18 mg)
|
Gnx vs Gnx + E2
|
E2 ↔ spatial memory (MWM)
[159]
|
APP+PS1
|
VCD 2-2.5 mos
|
Immediate s.c. E2 (0.36 mg) 90 d
|
VCD vs VCD+E2
|
E2 ↔ spatial/working memory (RAWM)
[160]
|
APPswe
|
P
4
Continuous
|
Gnx 3 mos
|
Immediate s.c. P4 (25 mg) 90 d
|
Gnx: Veh vs P4
|
P4 ↔ SAB (Y-maze)
[163, 164]
|
3xTg-AD
|
P4 ↑ open arm time, ↓ freezing (EPM, FST)
[164]
|
Gnx 6 mos
|
Immediate s.c. P4 (25 mg) 90+d
|
Gnx vs Gnx + P4
|
P4↔ spatial memory (NPR, MWM)
[169]
|
APPswe+ PSEN1ΔE9
|
P
4
Cyclical
|
Gnx 3 mos
|
Delayed s.c. P4 (2.8 mg) 10 d off/on
|
Gnx: Veh vs P4
|
P4 ↔ SAB (Y-maze)
[164]
|
3xTg-AD
|
P4↑ open arm time, ↓ freezing (EPM, FST)
[164]
|
E
2
+ P
4
Continuous
|
Gnx 3 mos
|
Immediate s.c. E2 (0.025 mg) + P4 (25 mg) 90 d
|
Gnx: Veh vs E2+ P4
|
E2+ P4 ↑ SAB (Y-maze)
[163]
|
3xTg-AD
|
Gnx 3 mos
|
Immediate s.c. E2 (0.025 mg) + P4(25 mg) 90 d
|
Gnx: Veh vs E2+ P4
|
E2+ P4 ↔SAB (Y-maze)
[164]
|
3xTg-AD
|
E2+P4 ↑ open arm time, ↓ freezing (FST, EPM)
[164]
|
E
2
+ P
4
Cyclical
|
Gnx 3 mos
|
Immediate s.c. E2 (0.025 mg) 90 d + P4 (2.8 mg) 30 d cycles
|
Gnx: Veh vs E2+ P4
|
E2+ P4 ↑ SAB (Y-maze)
[164]
|
3xTg-AD
|
E2+P4 ↑ open arm time, ↓ freezing (FST, EPM)
[164]
|
LH Depletion
|
21 mos
|
I.M. injection of leuprolide followed by depot (7.5 mg/kg)
|
Intact: Veh vs leuprolide
|
leuprolide ↑ SAB in aging (Y-maze)
[180]
|
Tg2576
|
Testosterone
|
Postnatal d1–7
|
IP injection of T (100 μg/d)
|
Intact: Veh vs T
|
T↔SAB (Y-maze)
[116]
|
3xTg-AD
|