Fig. 7

Anxiety-like behavior. Inhibiting mitochondrial oxidative stress reduced center duration (A) and center entries (B) in an open field arena (60.96 × 60.9 × 38.1 cm). No effects of CIH or sex were observed on center entries or center duration. Raw values are shown and error bars denote mean ± S.E.M. Analyzed by 3-way ANOVA with Fisher’s LSD multiple comparisons tests. ANOVA significance indicated by: **p ≤ 0.01; Post-hoc significance indicated by unique letters (p ≤ 0.05). Significant effect observed (A): MT (F_{1, 60} = 7.434; p = 0.008; η² = 0.110). Significant effect observed (B): MT (F_{1, 60} = 7.301; p = 0.009; η² = 0.101). CIH chronic intermittent hypoxia, MT MitoTEMPOL