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Fig. 7 | Biology of Sex Differences

Fig. 7

From: Sex disparities revealed by single-cell and bulk sequencing and their impacts on the efficacy of immunotherapy in esophageal cancer

Fig. 7

The key characteristics of CD8+ T cells in EC. (A) Major subtypes of identified CD8+ T cells. (B) The association between TCR clonotypes and CD8+ T cell populations. (C) Composition of different subtypes of CD8+ T cells in male and female. (D) Pathway activities estimated by GSVA in male and female. (E) The dynamic immune states of CD8+ T cells evaluated by Monocle and their proportions in male and female. (F-I) The proportion of exhausted CD8+ T cells in responders and non-responders in breast cancer (F), basal or squamous cell cancer (G), triple-negative breast cancer (H), and lung cancer (I)

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