Fig. 10

Sex differences in the gut–brain and gut–metabolic modules before and after SPS. A Heat map of the shared gut–brain module between males and females before SPS exposure, B heat map of the shared gut–brain module between males and females following SPS exposure, C heat map of the shared gut–metabolic module between males and females before SPS exposure, D heat map of the shared gut–metabolic module between males and females following SPS exposure. Due to technical difficulties stool samples were not collected from every single animal. Each symbol represents the value for an individual animal. Before SPS (blue bars—males control n = 6/7, SPS-R n = 5/6, SPS-S n = 5; pink bars—females control n = 8/9, SPS-R n = 6/7, SPS-S n = 5/6), following SPS (blue bars—males control n = 6/7, SPS-R n = 6, SPS-S n = 4; pink bars—females control n = 8, SPS-R n = 8, SPS-S n = 5/6). The values of acetyl-CoA to crotonyl-CoA were multiplied by 1000 to facilitate their integration into the heat map alongside the other data points