Sex-specific differences in intestinal microbiota associated with cardiovascular diseases

Garcia-Fernandez, Helena; Arenas-de Larriva, Antonio P.; Lopez-Moreno, Javier; Gutierrez-Mariscal, Francisco M.; Romero-Cabrera, Juan L.; Molina-Abril, Helena; Torres-Peña, Jose D.; Rodriguez-Cano, Diego; Malagon, Maria M.; Ordovas, Jose M.; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose; Camargo, Antonio

doi:10.1186/s13293-024-00582-7

Biology of Sex Differences

Table 4 Variable importance of the RF models

From: Sex-specific differences in intestinal microbiota associated with cardiovascular diseases

Men vs women with CHD model	Importance			CHD men vs non-CVD men model	Importance		CHD women vs non-CVD women model	Importance
g_UBA1819 (Ruminococcaceae)		♀	100.00	o_Peptostreptococcales_Tissierellales	♀	100.00	f_Coriobacteriaceae	♂	100.00
g_Ruminococcus			83.28	g_Blautia		89.11	c_Negativicutes	♂	80.17
g_Bilophila		♀	67.04	c_Negativicutes	♀	88.56	o_Peptostreptococcales_Tissierellales	♂	77.78
g_Coprobacter			50.15	f_Coriobacteriaceae	♀	80.76	f_UCG_010 (Oscillospirales)		73.80
g_Barnesiella			44.85	f_Streptococcaceae	♀	76.89	g_UCG_010		68.48
g_Alistipes			43.62	g_Collinsella	♀	68.36	g_Collinsella	♂	58.08
g_Phascolarctobacterium		♀	41.33	o_Lactobacillales	♀	67.19	Ruminococcaceae incertae sedis		57.79
g_Paraprevotella			38.80	g_Streptococcus	♀	60.19	g_Ruminococcus	♂	41.54
f_Ruminococcaceae			37.38	g_Ruminococcus	♀	57.57	c_Coriobacteriia	♂	37.40
f_Barnesiellaceae	♂		37.28	g_Subdoligranulum		54.89	f_Streptococcaceae	♂	37.17
g_Eubacterium_siraeum_group			36.53	c_Bacteroidia		54.28	o_Coriobacteriales		35.78
g_Subdoligranulum	♂		36.22	f_Sutterellaceae	♀	53.39	o_Lactobacillales	♂	35.33
g_Parabacteroides			34.08	g_UCG_002 (Oscillospiraceae)		48.34	p_Actinobacteriota		32.72
o_Oscillospirales			33.61	o_Burkholderiales	♀	47.15	g_Streptococcus	♂	31.54
f_Anaerovoracaceae			32.19	f_Oscillospiraceae		45.45	o_Burkholderiales	♂	28.56
f_Tannerellaceae			31.97	p_Bacteroidota		44.97	g_UBA1819 (Ruminococcaceae)		28.23
f_Prevotellaceae			31.86	p_Firmicutes		44.59	f_Butyricicoccaceae		27.22
g_Butyricimonas			31.73	o_Bacteroidales		42.07	g_Bilophila		27.11
Ruminococcaceae incertae sedis		♀	31.22	f_Barnesiellaceae		41.18	g_Phascolarctobacterium		26.92
f_Rikenellaceae			31.17	c_Coriobacteriia	♀	40.66	f_Sutterellaceae	♂	26.08

The sex-specific alterations in gut microbiota related to CHD were selected according to the following criteria: (1) bacterial taxa critical to distinguishing CHD men from non-CVD men or bacterial taxa critical to distinguishing CHD women from non-CVD women (2) bacterial taxa that significantly differentiated CHD men and CHD women. Men vs Women with CHD model: ♂, bacterial taxa that significantly differentiated CHD men and CHD women, which was also present among the main important variables on the CHD men vs non-CVD men model (in bold). ♂ bacterial taxa that significantly differentiated CHD men and CHD women, which was also present among the main important variables on the model CHD women vs non-CVD women model (in bold). CHD men vs non-CVD men model: bold, specific taxa in men model (these taxa did not appear in the CHD women vs non-CVD women model, and they are therefore specific to distinguishing CHD men from non-CVD men). ♂, taxa also present among the main important variables on the CHD women vs non-CVD women model. CHD women vs non-CVD women model: bold, specific taxa in women model (these taxa did not appear in the CHD men vs non-CVD men model, and they are therefore specific to distinguishing CHD women from non-CVD women). ♂, taxa also present among the main important variables on the CHD men vs non-CVD men model

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ISSN: 2042-6410

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