Fig. 1
From: Cocaine-induced sensitization and glutamate plasticity in the nucleus accumbens core: effects of sex
Effects of repeated systemic cocaine on psychomotor behavior in males and females. A Schematic displaying the experimental timeline. B Comparison of locomotor activity on day 1 between males (Mal) and females (Fem). Females showed a stronger response to the acute locomotor-activating effects of cocaine compared to males. C Male and D female locomotor behavior on day 1 vs day 8. Animals in cocaine groups (coc) increased locomotor behavior from day 1 to day 8 compared to saline (sal) treated controls. E Time to peak locomotor activity on day 1 and day 8 was faster following repeated cocaine treatment. * = Tukey’s post-test p ≤ 0.02; ## = Sidak’s post-test p < 0.01. All data shown as mean ± SEM