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Table 3 Allele association of 23 SNPs with type 2 diabetes stratified by diagnosis age and sex (N = 4040 chromosomes)

From: Sex differences in the influence of type 2 diabetes (T2D)-related genes, parental history of T2D, and obesity on T2D development: a case–control study

Locus (SNP)

ULR*

T2D diagnosis ≤ 45 years

T2D diagnosis ≥ 46 years

Females

(n = 1662)

Males

(n = 1404)

Females

(n = 1596)

Males

(n = 1384)

OR (95% CI)

p-Wald

OR (95% CI)

p-Wald

OR (95% CI)

p-Wald

OR (95% CI)

p-Wald

Group 1

        

 INS-IGF2 (rs149483638)

1.06 (0.8–1.3)

0.61

1.38 (1.1–1.8)a

0.014

1.1 (0.9–1.4)

0.44

1.56 (1.2–2)a

0.0010

 INS (rs689)

1.09 (0.8–1.4)

0.52

1.63 (1.2–2.1)a

0.0003

1.23 (1–1.6)a

0.11

1.43 (1.1–1.9)a

0.012

 KCNQ1 (rs2237897)

1.31 (1.1–1.6)

0.016

1.97 (1.5–2.5)a

 < 0.0001

1.09 (0.9–1.4)

0.46

1.56 (1.2–2)a

0.0002

 CDKN1C (rs163168)

1.36 (1.1–1.7)a

0.0043

1.82 (1.4–2.3)a

 < 0.0001

1.05 (0.8–1.3)

0.64

1.45 (1.2–1.8)a

0.0015

 SLC22A18 (rs450208)

1.46 (1.2–1.9)a

0.0014

1.27 (1–1.6)

0.053

1.38 (1.1–1.8)a

0.0092

1.36 (1.1–1.8)

0.015

Group 2

        

 IGF2BP2 (rs4402960)

1.16 (0.9–1.5)

0.26

1.65 (1.2–2.2)a

0.0007

1.09 (0.8–1.4)

0.54

1.37 (1–1.9)

0.042

 TCF7L2 (rs7903146)

1.22 (0.9–1.6)a

0.15

2.21 (1.6–3)a

 < 0.0001

1.15 (0.9–1.5)

0.34

1.83 (1.3–2.5)a

0.0003

 CDKN2A (rs10811661)

1.47 (1–2.2)a

0.049

0.92 (0.6–1.3)

0.65

1.07 (0.7–1.5)

0.73

1.08 (0.7–1.6)

0.72

 SLC30A8 (rs3802177)

1.31 (1–1.6)a

0.018

1.43 (1.1–1.8)a

0.0034

0.95 (0.7–1.2)a

0.65

0.96 (0.7–1.2)

0.77

 HNF1A (rs483353044)

1.92 (0.4–9.5)

0.43

1.97 (0.5–7.9)

0.34

2.85 (0.6–12.8)a

0.17

1.53 (0.3–6.9)

0.58

 WFS1 (rs4458523)

1.08 (0.8–1.4)

0.52

1.3 (1–1.7)a

0.065

0.99 (0.8–1.3)

0.95

0.99 (0.8–1.3)

0.94

 HMG20A (rs1005752)

0.97 (0.8–1.2)

0.81

1.04 (0.8–1.3)

0.73

0.87 (0.7–1.1)a

0.19

0.88 (0.7–1.1)a

0.27

Group 3

        

 SLC16A11 (rs75493593)

1.51 (1.2–1.9)a

 < 0.0001

1.34 (1.1–1.7)a

0.011

1.24 (1–1.5)a

0.048

1.14 (0.9–1.4)a

0.27

 IRS1 (rs1801278)

0.58 (0.3–1.2)

0.14

0.94 (0.5–1.9)

0.87

1.21 (0.7–2.2)a

0.53

1.35 (0.7–2.6)

0.38

 FABP2 (rs1799883)

0.89 (0.7–1.1)

0.34

1.23 (1–1.6)a

0.11

0.93 (0.7–1.2)

0.57

0.93 (0.7–1.2)

0.60

 CAPN10 (rs7607759)

0.76 (0.5–1.2)a

0.23

1.06 (0.6–1.8)

0.83

1.17 (0.8–1.8)

0.46

1.26 (0.8–2.1)

0.37

 PPP1R3A (rs1799999)

1.36 (1.1–1.7)a

0.0061

0.83 (0.6–1.1)

0.14

1.25 (1–1.6)a

0.060

0.94 (0.7–1.2)

0.64

 PTPRD (rs10511567)

1.28 (1–1.6)a

0.029

0.76 (0.6–1)a

0.036

1.16 (0.9–1.5)a

0.22

0.9 (0.7–1.1)

0.39

Group 4

        

 IL6 (rs1800795)

0.8 (0.5–1.2)

0.25

1.02 (0.7–1.6)

0.94

0.82 (0.6–1.2)

0.32

1.67 (1.1–2.5)a

0.0093

 NOS3 (rs2070744)

0.71 (0.5–1)a

0.028

0.86 (0.6–1.2)a

0.38

0.85 (0.6–1.1)

0.28

0.99 (0.7–1.4)

0.96

 CPED1 (rs10261386)

0.95 (0.8–1.2)

0.62

1.1 (0.9–1.4)

0.42

0.94 (0.8–1.2)

0.61

1.23 (1–1.5)

0.088

 KHDRBS3 (rs6577691)

0.9 (0.7–1.2)

0.52

0.73 (0.5–1)a

0.083

1.02 (0.7–1.4)

0.91

0.68 (0.5–1)a

0.046

 CACNA1H (rs4984636)

0.89 (0.6–1.2)

0.49

0.97 (0.7–1.4)

0.86

0.54 (0.4–0.8)a

0.0022

0.97 (0.7–1.4)

0.87

No. of SNPs

9

12

4

10

Sum of univariate R2

0.056

0.14

0.02

0.079

  1. CI confidence interval, OR odds ratio, R2 variability of T2D explained by these genes, SNP single nucleotide polymorphism, ULR univariate logistic regression
  2. aIndicates SNPs that remained in the multivariate model
  3. *All female (n = 1086) and male (n = 930) controls were compared with both groups of cases. The power (1 − β error probability) > 0.99 for all SNPs with P < 0.1
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Biology of Sex Differences

ISSN: 2042-6410

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