Fig. 5
Influence (R2) of obesity and fat distribution and genes and parental history on T2D development overlap. Overlapping analysis was performed with stratification by age of T2D diagnosis and sex. Overlapping analysis of A BMI with genes, B BMI with parental history, C WHR with genes, and D WHR with parental history are shown. The overlapping effect of R2 between genes and BMI and between parental history and BMI was observed by introducing BMI as the first block and either genes or parental history as the second block and then conducting the analysis with the blocks reversed. See legend of Fig. 2 for gene groups. BMI body mass index, PH parental history, T2D type 2 diabetes, WHR weight distribution