Fig. 6

Co-expressed gene expression clusters and pathway enrichment over early developmental time-course in mouse and human. A–D Unsupervised clusters of gene expression across developmental timepoints resulting from the non-negative matrix factorization (NMF) of expression data. Each plot depicts mean expression across samples for each stage in A male mouse clusters, B male human clusters, C female mouse clusters, and D female human clusters. In each graph, the other sex’s expression is co-mapped. E Heatmap of enriched Gene Ontology pathways (via GSEA) across NMF clusters reveals both concordance and nuance across female mouse, male mouse, female human, and male human samples