Fig. 1
Albuminuria and glomerular morphology in male and female SHRSP rats. a Urinary albumin:creatinine ratio (ACR); n = 5–9/group). b Quantification of glomerulosclerosis (mean glomerular % PAS-staining). c–f Glomerular size distribution, an index of glomerular hypertrophy, presented as the percentage of glomeruli vs glomerular area (µm2); n = 8–11/group. g Representative images of periodic acid-Schiff (PAS) staining; scale = 50 µM for all images. Data shown as mean ± SEM. a Data analyzed via a Kruskal–Wallis test with Dunn’s multiple comparisons (*P < 0.05). b Data via two-way ANOVA. c–f Groups analysed via two-way ANOVA followed by Tukey’s multiple comparisons tests. Pinteraction indicates a shift in the relationship between group comparisons