Table 2 Biological processes associated with sex-specific protein profiles
A. Top 5 enriched biological processes in women* | |||
|---|---|---|---|
ID | Name | p-value | Genes [# selected genes / # in annotation] |
GO:0030198 | Extracellular matrix organization | < 0.001 | [10/107]: MMP7, EGFL6, ANTXR1, COL11A2, PTK2, TNFRSF11B, COL13A1, Gal-3, MATN2, A2AP |
GO:0043062 | Extracellular structure organization | < 0.001 | [10/107]: MMP7, EGFL6, ANTXR1, COL11A2, PTK2, TNFRSF11B, COL13A1, Gal-3, MATN2, A2AP |
GO:0045229 | External encapsulating structure organization | < 0.001 | [10/107]: MMP7, EGFL6, ANTXR1, COL11A2, PTK2, TNFRSF11B, COL13A1, Gal-3, MATN2, A2AP |
GO:0043568 | Positive regulation of insulin-like growth factor receptor signaling pathway | < 0.001 | [3/7]: IGF-1, IGFBP-3, IGFBP-4 |
GO:0031104 | Dendrite regeneration | 0.003 | [2/3]: PTN, MATN2 |
B. Top 5 enriched biological processes in men* | |||
|---|---|---|---|
ID | Name | p-value | Genes [# in selection / # in annotation] |
GO:0043065 | Positive regulation of apoptotic process | 0.002 | [9/164]: PSA, NELL1, GCPII, HMOX1, SMPD1, CTSD, Agrin, IGF2R, ATF6 |
GO:0043068 | Positive regulation of programmed cell death | 0.002 | [9/166]: PSA, NELL1, GCPII, HMOX1, SMPD1, CTSD, Agrin, IGF2R, ATF6 |
GO:0010942 | Positive regulation of cell death | 0.004 | [9/182]: PSA, NELL1, GCPII, HMOX1, SMPD1, CTSD, Agrin, IGF2R, ATF6 |
GO:0050881 | Musculoskeletal movement | 0.001 | [2/9]: Mb, COMP |
GO:0050879 | Multicellular organismal movement | 0.001 | [2/9]: Mb, COMP |