Fig. 1

Deletion of Cpt1a in AgRP neurons affects feeding behavior in a sex-dependent manner. a, b Body weight in Cpt1aKO female in red (a, n = 8) and male mice in blue (b, n = 6) vs their control littermates (female n = 10, and male n = 9). c, d Cumulative food intake in female (c, n = 8–10) and male (d, n = 6–9) mice measured during 1 month after tamoxifen induction. e, f Analysis of food intake measured by the TSE system during light and dark phases in female (e, n = 6–6) and male mice during 3 consecutive days (f, n = 6–6). g, h Response to fasting–refeeding in female (g, n = 8–10) and male mice (h, n = 10–8). (i) Cumulative food intake measured 1 h after intraperitoneal (i.p.) ghrelin administration in female (n = 7–7) and male mice (n = 6–6). j Time that female (n = 7–7) and male mice (n = 6–6) spent eating after the ghrelin injection. Data are expressed as the mean ± SEM. In a–d, *p < 0.05, **p < 0.01, ****p < 0.0001, using two-way repeated-measures ANOVA followed by Šidák’s post hoc test. In e and f, * p < 0.05, using Student’s t-test. In g and h, *p < 0.05 using two-way repeated-measures ANOVA followed by Šidák’s post hoc test. In i–j, *p < 0.05, **p < 0.01, using Student’s t-test. In i–j *p < 0.05, ****p < 0.0001, using two-way ANOVA followed by Turkey post hoc test