Investigation of autism-related transcription factors underlying sex differences in the effects of bisphenol A on transcriptome profiles and synaptogenesis in the offspring hippocampus

Table 3 Neurological diseases and functions associated with ESR1 target genes that were differentially expressed in the hippocampus of male offspring prenatally exposed to BPA

Diseases or functions	p values	Genes	Number of genes
Neurological disorders
Growth failure or short stature	1.58E−07	Agps, Braf, Cdk13, Dchs1, Efnb2, Fgfr2, Fgfr3, Gja1, Ip6k1, Kdm2a, Kmt2e, Rev3l, Tial1, Trps1, Zbtb20	15
Autosomal dominant mental retardation	1.37E−05	Cdk13, Chd2, Cic, Kirrel3, Kmt2e, Zbtb20	6
Saethre–Chotzen syndrome	2.07E−05	Fgfr2, Fgfr3	2
Dwarfism	4.29E−04	Agps, Fgfr2, Fgfr3, Gja1, Trps1	5
Familial congenital anomaly of limb	4.98E−04	Fgfr2, Fgfr3, Gja1, Psd3, Trps1	5
Nervous system development and functions
Abnormal morphology of neurons	3.22E−05	B4galnt1, Braf, Cpeb3, Epha7, Fgfr3, Gja1, Itgb8, Kif5a, Map1a, Wnt4	10
Neuritogenesis	4.35E−05	Arfgef1, Braf, Cpeb3, Efnb2, Epha7, Fgfr2, Fgfr3, Gja1, Kirrel3, Plxnb1, Rhoq	11
Proliferation of neuronal cells	5.14E−05	Arfgef1, B4galnt1, Braf, Efnb2, Fgfr2, Fgfr3, Gja1, Kdm2a, Rhoq, Spock2	10
Branching morphogenesis of nerves	6.86E−05	Epha7, Fgfr2	2

Biological functions and diseases associated with ESR1 transcriptional targets that were differentially expressed in the hippocampus of male offspring prenatally exposed to BPA were predicted using IPA software. Statistical significance was determined using Fisher’s exact test. A p value < 0.05 was considered significant

ISSN: 2042-6410