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Fig. 2 | Biology of Sex Differences

Fig. 2

From: Sex differences in the associations of body size and body shape with platelets in the UK Biobank cohort

Fig. 2

Associations of ABSI and HI with platelet parameters. ABSI a body shape index; CI confidence interval; HI hip index; MPV mean platelet volume; PDW platelet distribution width; Post-MP post-menopausal women; Pre-MP pre-menopausal women; SD standard deviation. SDdifferences (95% CI) in platelet parameters per one SD increment of ABSI or HI from multivariable linear regression models including each platelet parameter as an outcome variable (sex-specific z-scores, following log-transformation) and body mass index (BMI), ABSI, and HI as exposure variables (sex-specific z-scores), with adjustment for height, age, weight change (last year), smoking status, alcohol consumption, physical activity, Townsend deprivation index, region of the assessment centre, time of blood collection, fasting time, use of nonsteroidal anti-inflammatory drugs, paracetamol use, menopausal status (women overall), hormonal replacement therapy use (women overall and Post-MP), oral contraceptives use and age at the last live birth (all women). Numerical values are shown in Additional file 1: Table S4. A p values for the interaction terms of ABSI and HI with sex, from a model including women (reference) and men, with adjustment for BMI, covariates (except female-specific), and including an interaction term of age with sex, to account for potential differences by menopausal status in women. B p values for the interaction terms of ABSI and HI with menopausal status, from a model including Pre-MP (reference) and Post-MP women, with adjustment for BMI and covariates. C p values for the interaction terms of ABSI and HI with age (continuous), from a model including all men, with adjustment for BMI and covariates (except female-specific). p values - p ≥ 0.05; *p < 0.05; **p < 0.001; *** p < 1 × 10–6

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