Fig. 2

Leuprolide exposure during the periadolescent period delayed pubertal onset. Top: on average, the day of vaginal opening was approximately one week later in leuprolide-treated female rats than saline controls (saline: n = 14; leuprolide: n = 10). Bottom: day of preputial separation was approximately 6 days later in leuprolide-treated male rats than saline controls (saline: n = 8; leuprolide: n = 8). Data are presented as the proportion of subjects in each group displaying vaginal opening or preputial separation across time