Placebo | Progesterone | ||||||
---|---|---|---|---|---|---|---|
N | Mean (SD) | Median [min, max] | N | Mean (SD) | Median [min, max] | ||
Baseline | |||||||
a. Progesterone (pg/mL) | |||||||
Males | 15 | 361.2 (120.3) | 347.0 [200, 580] | 18 | 362.3 (144.1) | 339.5 [175, 733] | |
Females | 16 | 837.1 (869.1) | 459.0 [109, 3070] | 17 | 932.3 (1457.4) | 405.0 [153, 6090] | |
Acute | |||||||
Males | 14 | 311.1 (104.3) | 302.0 [200, 590] | 17 | 5264.1 (3317.8) | 4690.0 [900, 14030] | |
Females | 15 | 959.1 (1054.8) | 439.0 [149, 3520] | 16 | 10,369.1 (9925.7) | 8440.0 [305, 36500] | |
Chronic | |||||||
Males | 15 | 285.9 (104.3) | 272.0 [198, 529] | 17 | 8199.4 (6521.2) | 5630.0 [1730, 20700] | |
Females | 15 | 1444.8 (2237.1) | 406.0 [132, 8230] | 15 | 10,732.0 (10,218.6) | 9730.0 [1540, 37360] | |
b. Allopregnanolone (pg/mL) | |||||||
Baseline | |||||||
Males | 15 | 54.4 (76.1) | 26.5 [3.0, 312.5] | 18 | 53.6 (75.2) | 31.2 [3.5, 286.2] | |
Females | 14 | 101.7 (58.6) | 94.8 [43.2, 250.6] | 17 | 122.3 (85.2) | 98.3 [10.7, 319.7] | |
Acute | |||||||
Males | 17 | 70.1 (72.3) | 41.1 [9.4, 258.3] | 19 | 6893.4 (7036.8) | 4548.7 [951.2, 31,885.8] | |
Females | 17 | 104.2 (68.5) | 103.5 [22.1, 246.6] | 15 | 5430.5 (4632.8) | 3905.6 [115.0, 12,727.3] | |
Chronic | |||||||
Males | 17 | 56.5 (60.7) | 36.3 [5.1, 252.5] | 19 | 6474.4 (4793.7) | 5600.4 [1007.4, 19,775.7] | |
Females | 15 | 142.2 (92.2) | 121.4 [32.0, 339.1] | 16 | 5551.5 (4477.0) | 5350.3 [213.2, 17,084.7] | |
c. Log (allopregnanolone/progesterone) | |||||||
Baseline | |||||||
Males | 14 | − 2.3 (0.9) | − 2.3 [− 4.4, − 0.6] | 17 | − 2.5 (1.0) | − 2.2 [− 4.6, − 0.8] | |
Females | 13 | − 1.7 (1.1) | − 1.4 [− 3.6, − 0.5] | 17 | − 1.7 (0.9) | − 1.8 [− 3.1, − 0.1] | |
Acute | |||||||
Males | 13 | − 1.9 (0.9) | − 1.9 [− 3.5, 0.1] | 17 | 0.0 (0.5) | 0.1 [− 1.4, 0.8] | |
Females | 14 | − 1.8 (1.1) | − 1.5 [− 3.7, − 0.4] | 13 | − 0.6 (0.7) | − 0.8 [− 1.5, 0.8] | |
Chronic | |||||||
Males | 15 | − 1.9 (0.8) | − 1.9 [− 3.7, − 0.2] | 17 | − 0.1 (0.8) | 0.0 [− 1.5, 0.8] | |
Females | 15 | − 1.7 (1.3) | − 1.0 [− 4.2, − 0.2] | 15 | − 0.8 (1.0) | − 0.7 [− 3.3, 1.2] |