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Table 3 a–c Raw data on blood levels of progesterone and allopregnanolone

From: Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

 

Placebo

Progesterone

N

Mean (SD)

Median

[min, max]

N

Mean (SD)

Median

[min, max]

Baseline

a. Progesterone (pg/mL)

 Males

15

361.2 (120.3)

347.0 [200, 580]

18

362.3 (144.1)

339.5 [175, 733]

 Females

16

837.1 (869.1)

459.0 [109, 3070]

17

932.3 (1457.4)

405.0 [153, 6090]

Acute

  Males

14

311.1 (104.3)

302.0 [200, 590]

17

5264.1 (3317.8)

4690.0 [900, 14030]

  Females

15

959.1 (1054.8)

439.0 [149, 3520]

16

10,369.1 (9925.7)

8440.0 [305, 36500]

Chronic

  Males

15

285.9 (104.3)

272.0 [198, 529]

17

8199.4 (6521.2)

5630.0 [1730, 20700]

  Females

15

1444.8 (2237.1)

406.0 [132, 8230]

15

10,732.0 (10,218.6)

9730.0 [1540, 37360]

b. Allopregnanolone (pg/mL)

Baseline

  Males

15

54.4 (76.1)

26.5 [3.0, 312.5]

18

53.6 (75.2)

31.2 [3.5, 286.2]

  Females

14

101.7 (58.6)

94.8 [43.2, 250.6]

17

122.3 (85.2)

98.3 [10.7, 319.7]

Acute

  Males

17

70.1 (72.3)

41.1 [9.4, 258.3]

19

6893.4 (7036.8)

4548.7 [951.2, 31,885.8]

  Females

17

104.2 (68.5)

103.5 [22.1, 246.6]

15

5430.5 (4632.8)

3905.6 [115.0, 12,727.3]

Chronic

  Males

17

56.5 (60.7)

36.3 [5.1, 252.5]

19

6474.4 (4793.7)

5600.4 [1007.4, 19,775.7]

  Females

15

142.2 (92.2)

121.4 [32.0, 339.1]

16

5551.5 (4477.0)

5350.3 [213.2, 17,084.7]

c. Log (allopregnanolone/progesterone)

Baseline

  Males

14

− 2.3 (0.9)

− 2.3 [− 4.4, − 0.6]

17

− 2.5 (1.0)

− 2.2 [− 4.6, − 0.8]

  Females

13

− 1.7 (1.1)

− 1.4 [− 3.6, − 0.5]

17

− 1.7 (0.9)

− 1.8 [− 3.1, − 0.1]

Acute

  Males

13

− 1.9 (0.9)

− 1.9 [− 3.5, 0.1]

17

0.0 (0.5)

0.1 [− 1.4, 0.8]

  Females

14

− 1.8 (1.1)

− 1.5 [− 3.7, − 0.4]

13

− 0.6 (0.7)

− 0.8 [− 1.5, 0.8]

Chronic

  Males

15

− 1.9 (0.8)

− 1.9 [− 3.7, − 0.2]

17

− 0.1 (0.8)

0.0 [− 1.5, 0.8]

  Females

15

− 1.7 (1.3)

− 1.0 [− 4.2, − 0.2]

15

− 0.8 (1.0)

− 0.7 [− 3.3, 1.2]

  1. Mean, standard deviation, median, and range of (a) progesterone, (b) allopregnanolone, and (c) the ratio of allopregnanolone:progesterone at baseline, the acute treatment timepoint, and the chronic treatment timepoint separated by drug (progesterone vs. placebo) and stratified by sex