Fig. 4

Sex, but not deletion of osteocytic miR21, causes differences in gastrocnemius muscle cross-sectional area (CSA) in OtmiR21Δ and miR21fl/fl mice. Gastrocnemius skeletal muscle CSA from female and male OtmiR21Δ and miR21fl/fl mice (N = 4/group). A Frequency distribution for fibers measured in muscles from female and male mice. Graphs on the right show the overlap of the fiber area for both genotypes. B Average CSA and number of fibers measured/sample. Two-way ANOVA analyses were used to determine significant differences (Additional file 2: Table S2). #p < 0.05 for overall male versus female comparisons