From: Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study
Characteristics | MCI-LB | DLB | PD-MCI | PDD | ||||
---|---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | |
Women vs. men (Ref.) | ||||||||
Demographicsa | ||||||||
Age at CI, y | − 1.49 ± 2.40 | – | − 1.05 ± 0.87 | – | − 1.47 ± 1.75 | – | − 2.64 ± 0.97** | – |
Age at PARK, y | − 28.02 ± 4.07*** | – | − 0.46 ± 1.03 | – | − 1.98 ± 1.92 | – | − 2.60 ± 1.05* | – |
Interval between CI and PARK, y | 2.72 ± 2.76 | – | 0.54 ± 0.25* | – | 0.49 ± 0.67 | – | − 0.02 ± 0.42 | – |
Course of disease, y | 0.05 ± 0.78 | – | 0.34 ± 0.20 | – | 0.28 ± 0.55 | – | − 0.53 ± 0.35 | – |
MRI visual scalesa | ||||||||
MTA scores | ||||||||
Left | – | − 0.09 ± 0.18 | – | − 0.02 ± 0.07 | – | 0.19 ± 0.09* | – | − 0.20 ± 0.07** |
Right | – | − 0.01 ± 0.18 | – | − 0.02 ± 0.08 | – | 0.18 ± 0.09* | – | − 0.16 ± 0.07* |
Fazekas scales | – | 0.14 ± 0.26 | – | − 0.01 ± 0.07 | – | 0.23 ± 0.11* | – | − 0.08 ± 0.07 |
Clinical assessmentsa | ||||||||
C-MMSE | – | − 1.24 ± 0.58* | – | 0.45 ± 0.67 | – | 0.05 ± 0.28 | – | − 0.02 ± 0.74 |
MoCA | – | − 1.01 ± 0.54 | – | 0.28 ± 0.55 | – | 0.61 ± 0.47 | – | − 0.03 ± 0.67 |
ADL | – | – | – | – | – | 0.95 ± 1.51 | – | − 0.30 ± 1.53 |
CDR | – | – | – | – | – | − 0.08 ± 0.08 | – | − 0.02 ± 0.09 |
NPI | – | 3.63 ± 2.04 | – | 6.04 ± 1.72** | – | – | – | − 1.82 ± 4.46 |
Delusions | – | 0.45 ± 0.26 | – | 0.87 ± 0.34* | – | – | – | 0.12 ± 0.60 |
Hallucinations | – | 0.61 ± 0.44 | – | 0.83 ± 0.36* | – | – | – | 0.43 ± 1.01 |
Agitation | – | 0.33 ± 0.43 | – | 0.17 ± 0.22 | – | – | – | − 0.004 ± 0.13 |
Depression | – | 0.26 ± 0.35 | – | 1.10 ± 0.31*** | – | – | – | 0.02 ± 0.03 |
Anxiety | – | 0.28 ± 0.20 | – | 0.80 ± 0.27** | – | – | – | − 1.01 ± 0.66 |
Euphoria | – | 0.07 ± 0.13 | – | − 0.15 ± 0.10 | – | – | – | − 0.03 ± 0.06 |
Apathy | – | − 0.29 ± 0.31 | – | 0.49 ± 0.33 | – | – | – | − 0.86 ± 1.30 |
Disinhibition | – | 0.31 ± 0.23 | – | − 0.02 ± 0.13 | – | – | – | 0.13 ± 0.10 |
Irritability | – | 0.95 ± 0.46* | – | 0.25 ± 0.24 | – | – | – | − 0.42 ± 0.48 |
Aberrant motor behavior | – | 0.33 ± 0.29 | – | 0.91 ± 0.34** | – | – | – | 0.63 ± 0.60 |
Night-time behavior disturbances | – | 0.002 ± 0.37 | – | 0.59 ± 0.36 | – | – | – | 0.13 ± 1.22 |
Appetite and eating abnormalities | – | 0.33 ± 0.31 | – | 0.27 ± 0.24 | – | – | – | − 0.71 ± 0.50 |
Core clinical featuresb | ||||||||
RBD | – | − 0.05 ± 1.11 | – | 0.23 ± 0.24 | – | − 1.85 ± 0.53** | – | − 0.28 ± 0.29 |
Parkinsonism | – | − 2.10 ± 0.97* | – | − 0.61 ± 0.25* | – | – | – | – |
Fluctuating cognition | – | 3.41 ± 1.31** | – | − 0.26 ± 0.23 | – | 0.70 ± 0.50 | – | 0.55 ± 0.30 |
Visual hallucinations | – | − 1.01 ± 0.99 | – | 0.08 ± 0.27 | – | 0.33 ± 0.49 | – | 0.50 ± 0.38 |