Table 1 Demographic and clinical information collection in this multicenter study
From: Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study
Items | Subitems | Other information |
|---|---|---|
Demographic data | Sex | Men or women |
Age at last visit | The age at patients’ last visit at each center | |
Educational years | ||
Onset age | The onset ages were recorded according to patients’ and/or caregivers’ chief complaints. We conducted the onset ages of cognitive impairment (n = 1038) and parkinsonism (n = 781) in this study | |
Interval between cognitive impairment and parkinsonism | The absolute value of onset age of cognitive impairment minus onset age of parkinsonism among the target patients. There were 781 pieces of data were analyzed, since a total of 781 patients (418 men and 363 women; 19 patients in MCI-LB, 331 patients in DLB, 118 patients in PD-MCI and 313 patients in PDD) had parkinsonism in this study | |
Course of disease | Age at last visit minus onset age | |
Sex ratio | Sex ratios mean the number of men divided women (men/women) | |
Clinical core features | Fluctuating cognition | The presence was diagnosed with three or more “yes” responses required for structured questions from caregivers confirmed by the Mayo Fluctuations Composite Scale |
Visual hallucinations | The hallucinations item of 12-item NPI was used to determine the presence of hallucination, as complaining about by the patient and/or caregiver with specifically formed and detailed VH and illusions | |
Parkinsonism | This is diagnosed by having one or more spontaneous cardinal features of parkinsonism included bradykinesia, rest tremor or rigidity evaluated by the motor section (Part III) of the Movement Disorders Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) | |
RBD | It can be confirmed by caregivers who mentioned five or more behaviors that are mentioned in the RBD screening questionnaire (RBD-SQ); or this patient was diagnosed by an overnight video polysomnography | |
Cognitive status | MCI or dementia | |
Clinical diagnosis at last visit | Probable MCI-LB, DLB, PD-MCI or PDD | The diagnostic criteria and clinical core features assessments are detailed described below |
Neuropsychological assessments | Mini-Mental State Examination (Chinese version) | Scores range from 0 (severe impairment) to 30 (no impairment). It is used to evaluate global cognitive function |
Montreal Cognitive Assessment | Scores range from 0 (severe impairment) to 30 (no impairment), It is used to evaluate global cognitive function | |
The Activities of daily living | Scores range from 20 (no impairment) to 80 (severe dysfunction), it is used to evaluate the functional status | |
The Clinical Dementia Rating | Scores range from 0.5 (MCI), 1.0 (mild), 2.0 (moderate) to 3.0 (severe), it is used to evaluate the severity of dementia | |
Neuropsychiatric Inventory* | Each subscale ranges between 0 (NPS) and 12 and the total composite score between 0 (no NPS) and 144, it is used to evaluate the presence and severity of NPS A total of 451 patients (61 patients with MCI-LB, 339 with DLB, 15 with PD-MCI and 36 with PDD) underwent NPI assessment in this study | |
MRI visual rating scales | Medial Temporal lobe Atrophy* | Scores range from 0 (no atrophy) to 4 (severe volume loss of hippocampal volume, it is used to evaluate the visual regional brain atrophy in the hippocampus, parahippocampal gyrus, entorhinal cortex and the surrounding cerebrospinal fluid spaces Multiplanar oblique coronal (perpendicular to the axis of the hippocampus), transverse and coronal position reconstructions were made of 3D T1-weighted images for diagnostic multisequence MRI. All of the MRI readings were reviewed by two experienced neuroradiologists double-blindly, and the final rating scores were averaged A total of 922 patients (74 patients with MCI-LB, 480 with DLB, 107 with PD-MCI and 261 with PDD) completed MRI visual rating scales |
Fazekas scales* | Scores range from 0 (no or single punctate lesion) to 3 (large confluent lesions), it is used to reflect the whole white matter lesion. The numbers of participants, the principles of MRI parameters and review are the same as described above | |
APOE genotype* | Genomic DNA was extracted from peripheral blood stored at -80 ℃, and the APOE gene was amplified by polymerase chain reaction. All genotypes were determined without knowledge of the patient status A total of 167 patients (40 patients with MCI-LB, 111 with DLB, 0 with PD-MCI and 16 with PDD) had the APOE genotype test |