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Table 2 Relative odds of diabetes according to uACR in different models among US adults

From: Sex modifies the association between urinary albumin-to-creatinine ratio and diabetes among adults in the United States (NHANES 2011–2018)

uACR, mg/g

Events (%)

Diabetes OR (95% CI), P value

Model 1

Model 2

Model 3

All participants

 Continuous (Lg uACR)

818 (15.41%)

3.89 (3.36, 4.50), < 0.001

1.90 (1.47, 2.46), < 0.001

1.81 (1.39, 2.34), < 0.001

 Tertile 1 (< 5)

119 (6.73%)

Reference

Reference

Reference

 Tertile 2 (5–10)

221 (12.49%)

1.98 (1.57, 2.50), < 0.001

1.36 (0.97, 1.91), 0.079

1.37 (0.97, 1.94) 0.077

 Tertile 3 (≥ 10)

478 (27.02%)

5.13 (4.15, 6.36), < 0.001

1.86 (1.33, 2.59), < 0.001

1.82 (1.29, 2.56), < 0.001

 P for trend

 

< 0.001

< 0.001

< 0.001

Male

 Continuous (Lg uACR)

484 (17.06%)

4.75 (3.91, 5.76), < 0.001

2.43 (1.72, 3.42), < 0.001

2.26 (1.59, 3.21), < 0.001

 Tertile 1 (< 4)

62 (6.55%)

Reference

Reference

Reference

 Tertile 2 (4–8)

116 (12.28%)

2.00 (1.45, 2.75), < 0.001

1.10 (0.68, 1.79), 0.693

1.11 (0.67, 1.81) 0.691

 Tertile 3 (≥ 8)

306 (32.35%)

6.82 (5.09, 9.12), < 0.001

1.95 (1.22, 3.10), 0.005

1.94 (1.20, 3.13) 0.007

 P for trend

 

< 0.001

0.002

0.003

Female

 Continuous (Lg uACR)

334 (13.52%)

2.99 (2.36, 3.78), < 0.001

1.23 (0.79, 1.90), 0.359

1.28 (0.82, 2.01), 0.278

 Tertile 1 (< 6)

66 (8.02%)

Reference

Reference

Reference

 Tertile 2 (6–11)

93 (11.30%)

1.46 (1.05, 2.04), 0.025

0.95 (0.59, 1.53), 0.843

0.96 (0.59, 1.57), 0.881

 Tertile 3 (≥ 11)

175 (21.24%)

3.09 (2.29, 4.18), < 0.001

1.07 (0.67, 1.70), 0.784

1.11 (0.68, 1.80), 0.678

 P for trend

 

< 0.001

0.751

0.644

 P value for interaction*

 

0.003

0.014

0.049

  1. Values are ORs (95% CIs) unless otherwise indicated. uACR, albumin-to-creatinine ratio. uACR value was log10-transformed
  2. Model 1 was adjusted for none
  3. Model 2 was adjusted for age, sex (only for overall population), race, poverty income ratio, BMI, SBP, DBP, current smoking, alcohol intake, FPG, TG, TC, HDL, LDL
  4. Model 3 was adjusted for age, sex (only for overall population), race, poverty income ratio, BMI, SBP, DBP, hypertension, current smoking, alcohol intake, FPG, TG, TC, HDL, LDL, eGFR, antihypertensive drugs, lipoprotein-lowering drugs
  5. *P value for interaction test: two-way interaction of sex and LguACR (continuous) on diabetes