Table 3 Ingenuity pathway analysis (IPA) comparison analysis of Gonzalez 2018 [33] and Braun 2020 [35]

mTOR signaling

1

1.633

Ferroptosis signaling pathway

− 0.816

− 0.816

ERK5 signaling

− 0.447

− 1

Endocannabinoid cancer inhibition pathway

1

0.333

PPAR signaling

1

0.302

NRF2-mediated oxidative stress response

0.447

0.447

ESR1

− 2.927

− 2.822

CD24

− 1.987

− 3.308

CPT1B

− 1.131

− 3.582

miR-30c-5p (and other miRNAs w/seed GUAAACA

1.89

2.796

PTPRR

− 1.987

− 2.28

ASPSCR1-TFE3

2.236

1.897

CD38

1.987

2.123

Mifepristone

1.8

2.142

PKD1

1.48

2.414

AR

− 1.998

− 1.842

GSKJ4

− 1.342

− 2.449

Firre

2

1.706

Tetraethylammonium

− 2

− 1.633

EGF

1.85

1.694

Valproic acid

− 1.37

− 1.977

TRAP1

− 1.342

− 2

Pirinixic acid

0.412

2.899

FN1

− 2.236

− 1.014

TCF4

1

2.1698

XBP1

1.945

1.212

ERBB2

2.709

0.358

SYVN1

2.449

0.577

TSC2

− 1.564

− 1.412

Topotecan

0.853

2.111

BMP4

1.869

1.021

Tamoxifen

1.424

1.373

Benzo(a)pyrene

1.4

1.39

SMARCA5

− 0.378

− 2.236

IGF2BP1

− 0.958

− 1.633

UBQLN2

− 1.387

− 0.816

Mek

− 1.187

− 0.982

MYCL

− 1.98

− 0.104

KLF3

1.155

0.728

Diseases and functions

Category

 Morbidity or mortality

1.118

3.865

 Organismal death

1.039

3.671

 Congenital encephalopathy

0.928

2.623

 Abdominal cancer

1.557

1.972

 Abdominal neoplasm

1.247

2.212

 Hematologic cancer

0.872

2.544

 Abdominal carcinoma

1.842

1.504

 Myeloid or lymphoid neoplasm

0.492

2.764

 Neoplasia of blood cells

0.377

2.84

 Formation of solid tumor

1.952

1.223

 Solid tumor

1.375

1.765

 Tumorigenesis of epithelial neoplasm

1.635

1.475

 Malignant solid organ tumor

− 1.091

− 1.969

 Intraabdominal organ tumor

0.976

2.081

 Skin cancer

− 1.067

− 1.98

 Development of digestive organ tumor

1.238

1.709

 Frequency of tumor

1.687

1.181

 Non-melanoma solid tumor

1.217

1.643

 Cancer

1.178

1.298

 Malignant solid tumor

1.456

0.981

 Extracranial solid tumor

1.098

1.309

 Growth failure or short stature

0.16

2.221

 Incidence of tumor

1.183

1.175

 Development of malignant tumor

1.368

0.849

 Digestive organ tumor

0.588

1.587

 Malignant genitourinary solid tumor

1.719

0.437

 Infection by RNA virus

1.067

0.994

 Infection of cells

1.319

0.716

 Development of carcinoma

1.3

0.623

 Infection by HIV-1

1.11

0.729

 HIV infection

1.11

0.729

 Digestive system cancer

0.368

1.46

 Viral infection

0.448

1.367

 Head and neck tumor

− 1.308

− 0.437

 Skin tumor

− 1.069

− 0.634

 Brain lesion

− 0.911

− 0.681

 Renal lesion

0.651

0.883

 Urinary tract tumor

0.152

1.342

 Anogenital cancer

1.193

0.269

 Connective or soft tissue tumor

1.331

0.113

 Development of urinary tract

− 0.97

− 0.391

 Infection of embryonic cell lines

0.137

1.213

 Genital tumor

0.446

0.763

 Pelvic tumor

0.11

1.04