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Table 3 Ingenuity pathway analysis (IPA) comparison analysis of Gonzalez 2018 [33] and Braun 2020 [35]

From: Sex at the interface: the origin and impact of sex differences in the developing human placenta

Canonical pathways Gonzalez 2018 Braun 2020
Category Z score
mTOR signaling 1 1.633
Ferroptosis signaling pathway − 0.816 − 0.816
ERK5 signaling − 0.447 − 1
Endocannabinoid cancer inhibition pathway 1 0.333
PPAR signaling 1 0.302
NRF2-mediated oxidative stress response 0.447 0.447
Upstream regulators Gonzalez 2018 Braun 2020
Category Z score
ESR1 − 2.927 − 2.822
CD24 − 1.987 − 3.308
CPT1B − 1.131 − 3.582
miR-30c-5p (and other miRNAs w/seed GUAAACA 1.89 2.796
PTPRR − 1.987 − 2.28
ASPSCR1-TFE3 2.236 1.897
CD38 1.987 2.123
Mifepristone 1.8 2.142
PKD1 1.48 2.414
AR − 1.998 − 1.842
GSKJ4 − 1.342 − 2.449
Firre 2 1.706
Tetraethylammonium − 2 − 1.633
EGF 1.85 1.694
Valproic acid − 1.37 − 1.977
TRAP1 − 1.342 − 2
Pirinixic acid 0.412 2.899
FN1 − 2.236 − 1.014
TCF4 1 2.1698
XBP1 1.945 1.212
ERBB2 2.709 0.358
SYVN1 2.449 0.577
TSC2 − 1.564 − 1.412
Topotecan 0.853 2.111
BMP4 1.869 1.021
Tamoxifen 1.424 1.373
Benzo(a)pyrene 1.4 1.39
SMARCA5 − 0.378 − 2.236
IGF2BP1 − 0.958 − 1.633
UBQLN2 − 1.387 − 0.816
Mek − 1.187 − 0.982
MYCL − 1.98 − 0.104
KLF3 1.155 0.728
Diseases and functions   
Category  
 Morbidity or mortality 1.118 3.865
 Organismal death 1.039 3.671
 Congenital encephalopathy 0.928 2.623
 Abdominal cancer 1.557 1.972
 Abdominal neoplasm 1.247 2.212
 Hematologic cancer 0.872 2.544
 Abdominal carcinoma 1.842 1.504
 Myeloid or lymphoid neoplasm 0.492 2.764
 Neoplasia of blood cells 0.377 2.84
 Formation of solid tumor 1.952 1.223
 Solid tumor 1.375 1.765
 Tumorigenesis of epithelial neoplasm 1.635 1.475
 Malignant solid organ tumor − 1.091 − 1.969
 Intraabdominal organ tumor 0.976 2.081
 Skin cancer − 1.067 − 1.98
 Development of digestive organ tumor 1.238 1.709
 Frequency of tumor 1.687 1.181
 Non-melanoma solid tumor 1.217 1.643
 Cancer 1.178 1.298
 Malignant solid tumor 1.456 0.981
 Extracranial solid tumor 1.098 1.309
 Growth failure or short stature 0.16 2.221
 Incidence of tumor 1.183 1.175
 Development of malignant tumor 1.368 0.849
 Digestive organ tumor 0.588 1.587
 Malignant genitourinary solid tumor 1.719 0.437
 Infection by RNA virus 1.067 0.994
 Infection of cells 1.319 0.716
 Development of carcinoma 1.3 0.623
 Infection by HIV-1 1.11 0.729
 HIV infection 1.11 0.729
 Digestive system cancer 0.368 1.46
 Viral infection 0.448 1.367
 Head and neck tumor − 1.308 − 0.437
 Skin tumor − 1.069 − 0.634
 Brain lesion − 0.911 − 0.681
 Renal lesion 0.651 0.883
 Urinary tract tumor 0.152 1.342
 Anogenital cancer 1.193 0.269
 Connective or soft tissue tumor 1.331 0.113
 Development of urinary tract − 0.97 − 0.391
 Infection of embryonic cell lines 0.137 1.213
 Genital tumor 0.446 0.763
 Pelvic tumor 0.11 1.04
  1. Activation z‐score represents the inferred activation states of predicted transcriptional regulators based on the IPA molecular network. Positive values = activated in male and/or inhibited in female, negative values = activated in female and/or inhibited in male, (IPA version update 12/13/2020)