From: Sex at the interface: the origin and impact of sex differences in the developing human placenta
First author | Year | DOI | Topic | Method | Bulk tissue/cell | Sampling location | Gestational age of sample | Sex reported? (Y/N) | Sex-based analysis? (Y/N) |
---|---|---|---|---|---|---|---|---|---|
Tsui | 2004 | Identify placental-specific transcripts in maternal blood | Microarray | Bulk tissue | Chorionic villi | 9–12 and 38–40 wks | N | N | |
Mikheev | 2008 | Profile placenta across gestation | Microarray | Bulk tissue | Chorionic villi | 6–8 and 15–16 wks | N | N | |
Founds | 2008 | Preeclampsia | Microarray | Bulk tissue | Chorionic villi | 10–12 wks | N | N | |
Rull | 2010 | Recurrent miscarriage | Microarray | Bulk tissue | Placenta biopsy (chorionic villi + basal plate) | 1st trimester | N | N | |
Sitras | 2012 | Placental development across gestation | Microarray | Bulk tissue | Chorionic villi | 9–12 wks | N | N | |
Pantham | 2012 | Antiphospholipid antibodies | Microarray | Primary explants | Placental tissue explants | 8–8.5 wks | N | N | |
Ghaffari-Tabrizi-Wizsy | 2014 | 1st trimester trophoblast vs. 3rd trimester endothelial degradome | Microarray | Primary cell cultures | Chorionic villi (1st trimester), chorionic plate (3rd trimester) | 7–10 wks | N | N | |
Roost | 2015 | Development from early to mid- pregnancy | RNA-seq | Bulk tissue | Amnion, chorion, chorionic villi, decidua, umbilical cord | 8.2–9.6, 16–18, and 21–22 wks | Y | N | |
James | 2015 | Characterize trophoblast subpopulations in early pregnancy | Microarray | Sorted cell (flow cytometry) | Chorionic villi | 5.6–12.5 wks | N | N | |
Leslie | 2015 | Preeclampsia | Microarray | Bulk tissue | Chorionic villi | 9–14 wks | N | N | |
Lassance | 2015 | Obesity/Insulin | Microarray | Primary cell culture | Primary cytotrophoblast culture | 7–12 wks | N | N | |
Tian | 2016 | Recurrent miscarriage | Microarray | Primary cell culture | Chorionic villi | 6–12 wks | N | N | |
Söber | 2016 | Recurrent miscarriage | RNA-seq | Bulk tissue | Chorionic villi | 6–12 wks | Y | N | |
Lim | 2017 | Placental development across gestation (w/ linked methylation data) | RNA-seq | Bulk tissue | Chorionic villi | 1st and early 2nd trimester | N | N | |
Lim | 2017 | Chromosomal abnormalities | Microarray | Bulk tissue | Chorionic villi | 11–13 wks | N | N | |
Weisblum | 2017 | Zika virus infection | RNA-seq | Organoid cultures | Primary decidual and chorionic villus organoid cultures | Early- and mid-gestation | N | N | |
Soncin | 2018 | Profile placenta across gestation | Microarray | Bulk tissue | Chorionic villi | 4–39 weeks | N | N | |
Liu | 2018 | Characterize placental cell subpopulations | RNA-seq | Single cell w/ pre-sorting (magnetic bead) | Chorionic villi (1st trimester), basal plate (2nd trimester) | 8 and 24 wks | N | N | |
Suryawanshi | 2018 | Characterize cells from first-trimester maternal–fetal interface | RNA-seq | Single cell and bulk tissue | Chorionic villi and decidua | 6–11 wks | Y | N | |
Vento-Tormo | 2018 | Characterize cells from first-trimester maternal–fetal interface | RNA-seq | Single cell w/ pre-sorting (flow cytometry) | Chorionic villi and decidua | 6–14 wks | N | N | |
Turco | 2018 | Validate source and source-derived organoid | Microarray | Bulk tissue | Chorionic villi | 6–8 and 10–12 wks | N | N | |
Huang | 2018 | Recurrent miscarriage | RNA-seq | Bulk tissue | Chorionic villi |  < 20 wks | N | N | |
Zhao | 2018 | IVF | Microarray | Bulk tissue | Chorionic villi | 7–8 wks | N | N | |
Gonzalez | 2019 | Fetal sex differences | RNA-seq | Bulk tissue | Chorionic villi | 10.5–13.5 wks | Y | Y | |
Lee | 2019 | IVF and non-IVF treatment | RNA-seq | Bulk tissue | Chorionic villi | 11–13 wks | Y | N | |
Sun | 2020 | Sexually dimorphic crosstalk at maternal–fetal interface | Single-cell and bulk RNA-seq | Single cell and bulk tissue | Chorionic villi and decidua | 10–13 wks | Y | Y | |
Braun | 2020 | Sex differences during fetal androgen exposure | RNA-seq | Bulk tissue | Chorionic villi | 11–16 wks | Y | Y | |
Flowers | 2021 | Sex differences in microRNA expression in first and third trimester human placenta | Small RNA-seq | Bulk tissue | Chorionic villi and placenta collected at delivery | 10.4–14.5 wks and 36.3–41.4 wks | Y | Y |