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Table 1 Summary of early human placenta transcriptome studies

From: Sex at the interface: the origin and impact of sex differences in the developing human placenta

First author Year DOI Topic Method Bulk tissue/cell Sampling location Gestational age of sample Sex reported? (Y/N) Sex-based analysis? (Y/N)
Tsui 2004 https://doi.org/10.1136/jmg.2003.016881 Identify placental-specific transcripts in maternal blood Microarray Bulk tissue Chorionic villi 9–12 and 38–40 wks N N
Mikheev 2008 https://doi.org/10.1177/1933719108322425 Profile placenta across gestation Microarray Bulk tissue Chorionic villi 6–8 and 15–16 wks N N
Founds 2008 https://doi.org/10.1016/j.placenta.2008.09.015 Preeclampsia Microarray Bulk tissue Chorionic villi 10–12 wks N N
Rull 2010 https://doi.org/10.1016/j.placenta.2012.11.032 Recurrent miscarriage Microarray Bulk tissue Placenta biopsy (chorionic villi + basal plate) 1st trimester N N
Sitras 2012 https://doi.org/10.1371/journal.pone.0033294 Placental development across gestation Microarray Bulk tissue Chorionic villi 9–12 wks N N
Pantham 2012 https://doi.org/10.1016/j.jri.2012.03.487 Antiphospholipid antibodies Microarray Primary explants Placental tissue explants 8–8.5 wks N N
Ghaffari-Tabrizi-Wizsy 2014 https://doi.org/10.1159/000381766 1st trimester trophoblast vs. 3rd trimester endothelial degradome Microarray Primary cell cultures Chorionic villi (1st trimester), chorionic plate (3rd trimester) 7–10 wks N N
Roost 2015 https://doi.org/10.1016/j.stemcr.2015.05.002 Development from early to mid- pregnancy RNA-seq Bulk tissue Amnion, chorion, chorionic villi, decidua, umbilical cord 8.2–9.6, 16–18, and 21–22 wks Y N
James 2015 https://doi.org/10.1530/REP-14-0646 Characterize trophoblast subpopulations in early pregnancy Microarray Sorted cell (flow cytometry) Chorionic villi 5.6–12.5 wks N N
Leslie 2015 https://doi.org/10.1016/j.ajpath.2015.06.020 Preeclampsia Microarray Bulk tissue Chorionic villi 9–14 wks N N
Lassance 2015 https://doi.org/10.1016/j.ajog.2015.02.026 Obesity/Insulin Microarray Primary cell culture Primary cytotrophoblast culture 7–12 wks N N
Tian 2016 https://doi.org/10.1002/path.4694 Recurrent miscarriage Microarray Primary cell culture Chorionic villi 6–12 wks N N
Söber 2016 https://doi.org/10.1038/srep38439 Recurrent miscarriage RNA-seq Bulk tissue Chorionic villi 6–12 wks Y N
Lim 2017 https://doi.org/10.1371/journal.pone.0181155 Placental development across gestation (w/ linked methylation data) RNA-seq Bulk tissue Chorionic villi 1st and early 2nd trimester N N
Lim 2017 https://doi.org/10.1186/s12864-017-3993-y Chromosomal abnormalities Microarray Bulk tissue Chorionic villi 11–13 wks N N
Weisblum 2017 https://doi.org/10.1128/JVI.01905-16 Zika virus infection RNA-seq Organoid cultures Primary decidual and chorionic villus organoid cultures Early- and mid-gestation N N
Soncin 2018 https://doi.org/10.1242/dev.156273 Profile placenta across gestation Microarray Bulk tissue Chorionic villi 4–39 weeks N N
Liu 2018 https://doi.org/10.1038/s41422-018-0066-y Characterize placental cell subpopulations RNA-seq Single cell w/ pre-sorting (magnetic bead) Chorionic villi (1st trimester), basal plate (2nd trimester) 8 and 24 wks N N
Suryawanshi 2018 https://doi.org/10.1126/sciadv.aau4788 Characterize cells from first-trimester maternal–fetal interface RNA-seq Single cell and bulk tissue Chorionic villi and decidua 6–11 wks Y N
Vento-Tormo 2018 https://doi.org/10.1038/s41586-018-0698-6 Characterize cells from first-trimester maternal–fetal interface RNA-seq Single cell w/ pre-sorting (flow cytometry) Chorionic villi and decidua 6–14 wks N N
Turco 2018 https://doi.org/10.1038/s41586-018-0753-3 Validate source and source-derived organoid Microarray Bulk tissue Chorionic villi 6–8 and 10–12 wks N N
Huang 2018 https://doi.org/10.1016/j.ebiom.2018.11.015 Recurrent miscarriage RNA-seq Bulk tissue Chorionic villi  < 20 wks N N
Zhao 2018 https://doi.org/10.19723/j.issn.1671-167X.2019.01.026 IVF Microarray Bulk tissue Chorionic villi 7–8 wks N N
Gonzalez 2019 https://doi.org/10.1186/s13293-018-0165-y Fetal sex differences RNA-seq Bulk tissue Chorionic villi 10.5–13.5 wks Y Y
Lee 2019 https://doi.org/10.1016/j.fertnstert.2018.11.005 IVF and non-IVF treatment RNA-seq Bulk tissue Chorionic villi 11–13 wks Y N
Sun 2020 https://doi.org/10.1210/clinem/dgaa503 Sexually dimorphic crosstalk at maternal–fetal interface Single-cell and bulk RNA-seq Single cell and bulk tissue Chorionic villi and decidua 10–13 wks Y Y
Braun 2020 https://doi.org/10.1007/s43032-020-00355-8 Sex differences during fetal androgen exposure RNA-seq Bulk tissue Chorionic villi 11–16 wks Y Y
Flowers 2021 https://doi.org/10.1093/biolre/ioab221 Sex differences in microRNA expression in first and third
trimester human placenta
Small RNA-seq Bulk tissue Chorionic villi and placenta collected at delivery 10.4–14.5 wks and 36.3–41.4 wks Y Y
  1. Bolded values indicate studies in which sex-based analysis is reported