Sex-biased and parental allele-specific gene regulation by KDM6A

Table 2 Number of allelic DEGs after Kdm6a KO

Allele	Group	Expression change	BC DEGs	CB DEGs	Overlap (BC and CB)
Maternal	A	Downregulated	109	133	0
Paternal	B	Downregulated	58	104	2
Biallelic	C	Downregulated	27	32	1
Total			194	269	3
Maternal	D	Upregulated	68	109	0
Paternal	E	Upregulated	71	62	1
Biallelic	F	Upregulated	50	27	0
Total			189	198	1

The number of downregulated and upregulated DEGs after Kdm6a KO is listed for each group (A-F, see text) at the maternal or paternal allele, at both alleles (biallelic), and the total number. BC and CB DEGs refer to differentially expressed genes between wt and Kdm6a KO clones from the BC and CB crosses. The number of genes that overlap between the BC and CB cells is listed in the last column. See also Fig. 3 and Additional file 11. For BC and CB cells there were 11,176 and 11,401 genes assessed from the maternal allele and 10,686 and 10,786 from the paternal allele, respectively

ISSN: 2042-6410