|
Clifton et al. 2014
|
Detection of relaxin receptor in the dorsoradial ligament, synovium, and articular cartilage of the trapeziometacarpal joint
|
Prospective Cohort
|
15 (67%)
|
F 59 (44–79), M 67 (56–79)
|
Undergoing TMC arthroplasty
|
Collection of intraoperative tissue samples
|
Immunostaining for relaxin receptor in dorsoradial ligaments and synovium
|
|
Em et al. 2015
|
Serum relaxin levels in benign hypermobility syndrome
|
Prospective Case Control
|
88 (100%); 48 BJHS and 40 control
|
BJHS 25.2 + 6.6, control 25.4 + 7.1
|
Women diagnosed with benign joint hypermobility syndrome by the research team
|
Assessment for hypermobility (via Beighton, Brighton), serum relaxin levels
|
Average luteal SRC in women with BJHS vs. controls (all female); the presence of specific musculoskeletal pathologies in each group
|
|
Lubahn et al. 2006
|
Immunohistochemical detection of relaxin binding to the volar oblique ligament
|
Prospective cohort study
|
8 (100%)
|
Specified only as peri- or premenopausal
|
Non-menopausal women undergoing TMC arthroplasty, reconstruction of FCR
|
Collection of intraoperative tissue samples
|
Presence of relaxin receptors in volar oblique ligament
|
|
Pokorny et al. 2000
|
Self-reported oral contraceptive use and peripheral joint laxity
|
Prospective Cohort
|
55 (100%); 25 control and 30 test
|
Range 20–25
|
Women aged 20–25 on low-dose OCPs for 3 + months (test group) or not taking contraceptives for 3 + months (control group)
|
Passive anterior translation of tibia, 5th DIP hyperextension, and 2nd PIP abduction/adduction
|
Laxity of knee and hand between oral contraceptive users and non-users
|
|
Wolf et al. 2012
|
Serum relaxin is correlated with relaxin receptors and MMP-1 in the anterior oblique ligament
|
Prospective Cohort
|
49 (61%)
|
62 (43–78)
|
Patients undergoing TMC arthroplasty, trapeziectomy, and ligament reconstruction
|
Preoperative Beighton laxity score and serum relaxin level, intraoperative tissue sampling
|
Serum relaxin levels and relaxin receptor concentration in the anterior oblique ligament, relationship between MMP-1/MMP-13 and relaxin receptor location
|
|
Wolf, et al. 2013
|
Relationship of serum relaxin to generalized and trapezial–metacarpal Joint laxity
|
Prospective Cohort
|
289 (53%)
|
47 (18–91)
|
Healthy volunteers
|
Screening for hypermobility (Beighton), TMC stress X-rays, SRC testing
|
Serum relaxin levels and the effect on generalized and trapezial–metacarpal joint laxity
|
