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Table 1 Properties of Included Studies

From: Menstrual hormone-induced cyclic thumb CMC instability and degeneration in women: a systematic review

Author, year Title Study type Subject number (%F) Mean age (years) Subject factor(s) of interest Interventions and/or information collected Outcome variable(s)
Clifton et al. 2014 Detection of relaxin receptor in the dorsoradial ligament, synovium, and articular cartilage of the trapeziometacarpal joint Prospective Cohort 15 (67%) F 59 (44–79), M 67 (56–79) Undergoing TMC arthroplasty Collection of intraoperative tissue samples Immunostaining for relaxin receptor in dorsoradial ligaments and synovium
Em et al. 2015 Serum relaxin levels in benign hypermobility syndrome Prospective Case Control 88 (100%); 48 BJHS and 40 control BJHS 25.2 + 6.6, control 25.4 + 7.1 Women diagnosed with benign joint hypermobility syndrome by the research team Assessment for hypermobility (via Beighton, Brighton), serum relaxin levels Average luteal SRC in women with BJHS vs. controls (all female); the presence of specific musculoskeletal pathologies in each group
Lubahn et al. 2006 Immunohistochemical detection of relaxin binding to the volar oblique ligament Prospective cohort study 8 (100%) Specified only as peri- or premenopausal Non-menopausal women undergoing TMC arthroplasty, reconstruction of FCR Collection of intraoperative tissue samples Presence of relaxin receptors in volar oblique ligament
Pokorny et al. 2000 Self-reported oral contraceptive use and peripheral joint laxity Prospective Cohort 55 (100%); 25 control and 30 test Range 20–25 Women aged 20–25 on low-dose OCPs for 3 + months (test group) or not taking contraceptives for 3 + months (control group) Passive anterior translation of tibia, 5th DIP hyperextension, and 2nd PIP abduction/adduction Laxity of knee and hand between oral contraceptive users and non-users
Wolf et al. 2012 Serum relaxin is correlated with relaxin receptors and MMP-1 in the anterior oblique ligament Prospective Cohort 49 (61%) 62 (43–78) Patients undergoing TMC arthroplasty, trapeziectomy, and ligament reconstruction Preoperative Beighton laxity score and serum relaxin level, intraoperative tissue sampling Serum relaxin levels and relaxin receptor concentration in the anterior oblique ligament, relationship between MMP-1/MMP-13 and relaxin receptor location
Wolf, et al. 2013 Relationship of serum relaxin to generalized and trapezial–metacarpal Joint laxity Prospective Cohort 289 (53%) 47 (18–91) Healthy volunteers Screening for hypermobility (Beighton), TMC stress X-rays, SRC testing Serum relaxin levels and the effect on generalized and trapezial–metacarpal joint laxity