Clifton et al. 2014
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Detection of relaxin receptor in the dorsoradial ligament, synovium, and articular cartilage of the trapeziometacarpal joint
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Prospective Cohort
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15 (67%)
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F 59 (44–79), M 67 (56–79)
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Undergoing TMC arthroplasty
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Collection of intraoperative tissue samples
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Immunostaining for relaxin receptor in dorsoradial ligaments and synovium
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Em et al. 2015
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Serum relaxin levels in benign hypermobility syndrome
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Prospective Case Control
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88 (100%); 48 BJHS and 40 control
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BJHS 25.2 + 6.6, control 25.4 + 7.1
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Women diagnosed with benign joint hypermobility syndrome by the research team
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Assessment for hypermobility (via Beighton, Brighton), serum relaxin levels
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Average luteal SRC in women with BJHS vs. controls (all female); the presence of specific musculoskeletal pathologies in each group
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Lubahn et al. 2006
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Immunohistochemical detection of relaxin binding to the volar oblique ligament
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Prospective cohort study
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8 (100%)
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Specified only as peri- or premenopausal
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Non-menopausal women undergoing TMC arthroplasty, reconstruction of FCR
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Collection of intraoperative tissue samples
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Presence of relaxin receptors in volar oblique ligament
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Pokorny et al. 2000
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Self-reported oral contraceptive use and peripheral joint laxity
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Prospective Cohort
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55 (100%); 25 control and 30 test
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Range 20–25
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Women aged 20–25 on low-dose OCPs for 3 + months (test group) or not taking contraceptives for 3 + months (control group)
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Passive anterior translation of tibia, 5th DIP hyperextension, and 2nd PIP abduction/adduction
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Laxity of knee and hand between oral contraceptive users and non-users
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Wolf et al. 2012
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Serum relaxin is correlated with relaxin receptors and MMP-1 in the anterior oblique ligament
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Prospective Cohort
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49 (61%)
|
62 (43–78)
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Patients undergoing TMC arthroplasty, trapeziectomy, and ligament reconstruction
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Preoperative Beighton laxity score and serum relaxin level, intraoperative tissue sampling
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Serum relaxin levels and relaxin receptor concentration in the anterior oblique ligament, relationship between MMP-1/MMP-13 and relaxin receptor location
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Wolf, et al. 2013
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Relationship of serum relaxin to generalized and trapezial–metacarpal Joint laxity
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Prospective Cohort
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289 (53%)
|
47 (18–91)
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Healthy volunteers
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Screening for hypermobility (Beighton), TMC stress X-rays, SRC testing
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Serum relaxin levels and the effect on generalized and trapezial–metacarpal joint laxity
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