Table 1 Properties of Included Studies
Author, year | Title | Study type | Subject number (%F) | Mean age (years) | Subject factor(s) of interest | Interventions and/or information collected | Outcome variable(s) |
|---|---|---|---|---|---|---|---|
Clifton et al. 2014 | Detection of relaxin receptor in the dorsoradial ligament, synovium, and articular cartilage of the trapeziometacarpal joint | Prospective Cohort | 15 (67%) | F 59 (44–79), M 67 (56–79) | Undergoing TMC arthroplasty | Collection of intraoperative tissue samples | Immunostaining for relaxin receptor in dorsoradial ligaments and synovium |
Em et al. 2015 | Serum relaxin levels in benign hypermobility syndrome | Prospective Case Control | 88 (100%); 48 BJHS and 40 control | BJHS 25.2 + 6.6, control 25.4 + 7.1 | Women diagnosed with benign joint hypermobility syndrome by the research team | Assessment for hypermobility (via Beighton, Brighton), serum relaxin levels | Average luteal SRC in women with BJHS vs. controls (all female); the presence of specific musculoskeletal pathologies in each group |
Lubahn et al. 2006 | Immunohistochemical detection of relaxin binding to the volar oblique ligament | Prospective cohort study | 8 (100%) | Specified only as peri- or premenopausal | Non-menopausal women undergoing TMC arthroplasty, reconstruction of FCR | Collection of intraoperative tissue samples | Presence of relaxin receptors in volar oblique ligament |
Pokorny et al. 2000 | Self-reported oral contraceptive use and peripheral joint laxity | Prospective Cohort | 55 (100%); 25 control and 30 test | Range 20–25 | Women aged 20–25 on low-dose OCPs for 3 + months (test group) or not taking contraceptives for 3 + months (control group) | Passive anterior translation of tibia, 5th DIP hyperextension, and 2nd PIP abduction/adduction | Laxity of knee and hand between oral contraceptive users and non-users |
Wolf et al. 2012 | Serum relaxin is correlated with relaxin receptors and MMP-1 in the anterior oblique ligament | Prospective Cohort | 49 (61%) | 62 (43–78) | Patients undergoing TMC arthroplasty, trapeziectomy, and ligament reconstruction | Preoperative Beighton laxity score and serum relaxin level, intraoperative tissue sampling | Serum relaxin levels and relaxin receptor concentration in the anterior oblique ligament, relationship between MMP-1/MMP-13 and relaxin receptor location |
Wolf, et al. 2013 | Relationship of serum relaxin to generalized and trapezial–metacarpal Joint laxity | Prospective Cohort | 289 (53%) | 47 (18–91) | Healthy volunteers | Screening for hypermobility (Beighton), TMC stress X-rays, SRC testing | Serum relaxin levels and the effect on generalized and trapezial–metacarpal joint laxity |