Table 1 Demographics and biometric, psychometric, sleep and biomarker data
Females N = 119 (60%) | Males N = 79 (40%) | P value | |
|---|---|---|---|
Demographics | Mean ± SD or % or Median (IQR) | ||
Age, years | 64 ± 11 | 67 ± 11 | 0.06 |
Non-white race | 33 | 22 | 0.12 |
Body mass index, kg/m2 | 27.5 (23.8, 31.7) | 26.6 (24.6, 29.9) | 0.73 |
Systolic BP, mmHg | 120 (110,132) | 122 (112, 136) | 0.16 |
Diastolic BP, mmHg | 68 (62, 74) | 70 (66, 76) | 0.019 |
History of diabetes, % | 19 | 23 | 0.68 |
History of smoking, % | 37 | 41 | 0.73 |
Total cholesterol, mg/dL | 148 (127, 190) | 149 (123, 182) | 0.79 |
LDL cholesterol, mg/dL | 68 (53, 97) | 77 (57, 106) | 0.07 |
HDL cholesterol, mg/dL | 54 (43, 67) | 42 (36, 50) | < 0.001 |
Triglycerides, mg/dL | 88 (64, 119) | 110 (76, 158) | 0.002 |
Aspirin use, % | 82 | 89 | 0.32 |
Statin use, % | 85 | 86 | 0.98 |
Biometric indices | Median (IQR) or Mean ± SD | ||
Steps per week | 5,559 (3,423, 7,959) | 6,008 (4,807, 9,080) | 0.06 |
Physical activity, min/week | |||
Light level | 202 (146, 251) | 180 (156, 227) | 0.38 |
Moderate/vigorous level | 39 (32, 53) | 37 (24, 51) | 0.24 |
Heart rate, beats/min | |||
During rest | 67 ± 8 | 66 ± 8 | 0.39 |
During activity | 84 ± 11 | 82 ± 8 | 0.24 |
Psychometric indices* | Mean ± SD or Median (IQR) | ||
PROMIS scores | |||
Global physical health | 45 ± 9 | 50 ± 9 | 0.001 |
Physical function | 43 (38, 51) | 49 (43, 53) | 0.001 |
Depression | 52 (41, 56) | 41 (41, 54) | 0.020 |
Anxiety | 54 (49, 58) | 52 (44, 57) | 0.039 |
Fatigue | 53 (46, 61) | 49 (40, 55) | 0.003 |
Sleep disturbance | 54 (46, 57) | 48 (44, 53) | < 0.001 |
SAQ-7 scores | |||
Overall | 72 (51, 85) | 82 (73, 90) | 0.001 |
Physical limitation | 75 (50, 100) | 92 (67, 100) | 0.013 |
KCCQ scores | |||
Quality of life | 63 (38, 88) | 75 (63, 88) | < 0.001 |
Physical limitation | 83 (52, 100) | 92 (67, 100) | 0.025 |
Sleep duration** (hours per day) | 6.9 (6.3, 7.7) | 6.8 (6.0, 7.3) | 0.029 |
Cardiovascular risk biomarkers† | Median (IQR) | ||
NT-proBNP (pgram/ml) | 104 (59, 207) | 185 (75, 527) | 0.001 |
u-hs-cTnI (ng/L) | 1.25 (0.79, 2.68) | 4.50 (1.97, 7.12) | < 0.001 |
hs-CRP (mg/dL) | 0.15 (0.06, 0.40) | 0.10 (0.04, 0.24) | 0.08 |
Proportion with elevated biomarker levels† | % | ||
NT-proBNP | 16.0% (19/119) | 32.9% (26/79) | 0.005 |
u-hs-cTnI | 16.0% (19/119) | 46.8% (37/79) | < 0.001 |
hs-CRP | 31.9% (38/119) | 21.5% (17/79) | 0.11 |