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Table 1 Demographics and biometric, psychometric, sleep and biomarker data

From: Sex-based differences in remote monitoring of biometric, psychometric and biomarker indices in stable ischemic heart disease

  Females N = 119 (60%) Males N = 79 (40%) P value
Demographics Mean ± SD or % or Median (IQR)
 Age, years 64 ± 11 67 ± 11 0.06
 Non-white race 33 22 0.12
 Body mass index, kg/m2 27.5 (23.8, 31.7) 26.6 (24.6, 29.9) 0.73
 Systolic BP, mmHg 120 (110,132) 122 (112, 136) 0.16
 Diastolic BP, mmHg 68 (62, 74) 70 (66, 76) 0.019
 History of diabetes, % 19 23 0.68
 History of smoking, % 37 41 0.73
 Total cholesterol, mg/dL 148 (127, 190) 149 (123, 182) 0.79
 LDL cholesterol, mg/dL 68 (53, 97) 77 (57, 106) 0.07
 HDL cholesterol, mg/dL 54 (43, 67) 42 (36, 50)  < 0.001
 Triglycerides, mg/dL 88 (64, 119) 110 (76, 158) 0.002
 Aspirin use, % 82 89 0.32
 Statin use, % 85 86 0.98
Biometric indices Median (IQR) or Mean ± SD
 Steps per week 5,559 (3,423, 7,959) 6,008 (4,807, 9,080) 0.06
 Physical activity, min/week    
  Light level 202 (146, 251) 180 (156, 227) 0.38
  Moderate/vigorous level 39 (32, 53) 37 (24, 51) 0.24
  Heart rate, beats/min    
  During rest 67 ± 8 66 ± 8 0.39
  During activity 84 ± 11 82 ± 8 0.24
Psychometric indices* Mean ± SD or Median (IQR)
 PROMIS scores    
  Global physical health 45 ± 9 50 ± 9 0.001
  Physical function 43 (38, 51) 49 (43, 53) 0.001
  Depression 52 (41, 56) 41 (41, 54) 0.020
  Anxiety 54 (49, 58) 52 (44, 57) 0.039
  Fatigue 53 (46, 61) 49 (40, 55) 0.003
  Sleep disturbance 54 (46, 57) 48 (44, 53)  < 0.001
 SAQ-7 scores    
  Overall 72 (51, 85) 82 (73, 90) 0.001
  Physical limitation 75 (50, 100) 92 (67, 100) 0.013
 KCCQ scores    
  Quality of life 63 (38, 88) 75 (63, 88)  < 0.001
  Physical limitation 83 (52, 100) 92 (67, 100) 0.025
Sleep duration** (hours per day) 6.9 (6.3, 7.7) 6.8 (6.0, 7.3) 0.029
Cardiovascular risk biomarkers† Median (IQR)
 NT-proBNP (pgram/ml) 104 (59, 207) 185 (75, 527) 0.001
 u-hs-cTnI (ng/L) 1.25 (0.79, 2.68) 4.50 (1.97, 7.12)  < 0.001
 hs-CRP (mg/dL) 0.15 (0.06, 0.40) 0.10 (0.04, 0.24) 0.08
Proportion with elevated biomarker levels† %
NT-proBNP 16.0% (19/119) 32.9% (26/79) 0.005
u-hs-cTnI 16.0% (19/119) 46.8% (37/79)  < 0.001
hs-CRP 31.9% (38/119) 21.5% (17/79) 0.11
  1. *For the PROMIS, higher scores represented more of the concept being measured; for both the KCCQ and SAQ, the range of possible subscale scores was 0 to 100, with 100 representing the least burden of symptoms
  2. **Values are based on entries that contained non-zero or non-NA values
  3. †NT‐proBNP N‐terminal pro‐b‐type natriuretic peptide); u‐hs‐cTnI ultra‐high sensitivity cardiac‐specific troponin I), hs‐CRP high‐sensitivity C‐reactive protein; levels of each biomarker were considered elevated if u-hs-cTnI > 5 ng/L, NT-pro-BNP > 300 pgram/mL and hs-CRP > 0.3 mg/dL, respectively
  4. Significant p-values are in bold
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Biology of Sex Differences

ISSN: 2042-6410

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