Fig. 6

Left-specific H3K27ac occupancy coincides with higher gene expression in left gonad in females but not males. A The overall expression levels of female left-specific H3K27ac-associated genes (n = 1555) among different gonads. Note the average mRNA levels of female left-specific H3K27ac-associated genes were significantly higher in the female left than the female right. But in males, these genes were equally expressed. Kolmogorov–Smirnov test was performed to compare the overall gene expression levels. *p < 0.05, ns: not significant. B The expression levels of male left-specific H3K27ac-associated genes (n = 1552) among different gonads. The mRNA levels of male left-specific H3K27ac-associated genes were not different between left and right gonads in either sex. C The GO analysis of the female left-specific H3K27ac-associated genes indicates that cell cycle and ovarian development-related pathways were enriched