Fig. 3

Analysis of circulating parameters in stabilized and deteriorated COVID-19 patients. Lymphocyte and neutrophil number, D-Dimer, ferritin, E2, testosterone, soluble ACE2 and Ang1-7 plasma levels were analysed in total (A), female (B) and male (C) patients, divided in two groups: (i) patients with deteriorated disease, when the worst P/F during hospitalization was < 200 mmHg and was lower than that observed at admission; (ii) patients with stabilized disease, when the worst P/F during hospitalization was P/F  ≥ 200 mmHg, indicating mild/no ARDS and when the worst P/F was < 200 mmHg, but higher or equal to that observed at admission. Data referred to parameters are reported as mean ± SD. Data were analysed using Mann–Whitney U test. *P < 0.05 was considered statistically significant