Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Table 4 Echocardiographic parameters in females 16 weeks after induction of Ampkα2 deletion by tamoxifen injection

Echocardiographic parameters	Ampkα2^f/f n = 7	Ampkα2ciKO n = 6
HR (beats/min)	384 ± 30	447 ± 35
IVSd (mm)	0.97 ± 0.12	0.99 ± 0.09
IVSs (mm)	1.49 ± 0.12	1.56 ± 0.15
LVIDd (mm)	2.76 ± 0.21	2.55 ± 0.16
LVIDs (mm)	1.50 ± 0.16	1.30 ± 0.12
LVPWd (mm)	1.10 ± 0.07	1.03 ± 0.03
LVPWs (mm)	1.48 ± 0.08	1.46 ± 0.10
EDV (ml)	0.07 ± 0.01	0.05 ± 0.01
ESV (ml)	0.12 ± 0.02	0.09 ± 0.01
EF (%)	81.1 ± 4.4	82.4 ± 0.4
SV (ml)	0.05 ± 0.01	0.05 ± 0.01
FS (%)	45.4 ± 4.7	47.1 ± 1.0
CO (ml/min)	18.4 ± 4.3	21.2 ± 3.6

HR, heart rate; IVSd, interventricular septal thickness at end-diastole; IVSs, interventricular septal thickness at end-systole; LVIDd, left ventricular internal dimension at end-diastole; LVIDs, left ventricular internal dimension at end-systole; LVWPd, left ventricular posterior wall thickness at end-diastole; LVWPs, left ventricular posterior wall thickness at end-systole; EDV, end-diastolic volume; ESV, end-systolic volume; EF, left ventricular ejection fraction; SV, stroke volume; FS, left ventricular fractional shortening; CO, cardiac output

ISSN: 2042-6410