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Table 4 The association of plasma selenium with the risk of first stroke (total and subtypes) by sexa

From: Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study

 

bMale participants

Female participants

Cases/controls

Model 1

Model 2

Cases/controls

Model 1

Model 2

OR (95% CI) P value

OR (95% CI) P value

OR (95% CI) P value

OR (95% CI) P value

First total stroke

Selenium tertiles

 T1 (< 79.1 ng/mL)

206/193

Ref.

Ref.

214/224

Ref.

Ref.

 T2 (79.1 to < 94.1)

218/183

1.12 (0.84, 1.49) 0.452

1.11 (0.80, 1.54) 0.519

216/219

1.04 (0.80, 1.36) 0.764

0.88 (0.65, 1.19) 0.408

 T3 (≥ 94.1)

197/245

0.73 (0.55, 0.98) 0.034

0.67 (0.48, 0.93) 0.017

204/191

1.14 (0.85, 1.54) 0.380

0.85 (0.61, 1.19) 0.353

Selenium Categories

 T1–T2 (< 94.1)

424/376

Ref.

Ref.

430/443

Ref.

Ref.

 T3 (≥ 94.1)

197/245

0.69 (0.54, 0.89) 0.003

0.63 (0.48, 0.83) 0.001

204/191

1.12 (0.86, 1.44) 0.399

0.92 (0.69, 1.22) 0.563

First ischemic stroke

Selenium tertiles

 T1 (< 79.1 ng/mL)

179/171

Ref.

Ref.

181/192

Ref.

Ref.

 T2 (79.1 to < 94.1)

191/157

1.16 (0.85, 1.57) 0.343

1.17 (0.82, 1.66) 0.387

181/183

1.05 (0.79, 1.40) 0.716

0.90 (0.64, 1.25) 0.514

 T3 (≥ 94.1)

168/210

0.74 (0.55, 1.01) 0.058

0.67 (0.47, 0.95) 0.027

179/166

1.17 (0.85, 1.60) 0.330

0.84 (0.58, 1.21) 0.347

Selenium categories

 T1–T2 (< 94.1)

370/328

Ref.

Ref.

362/375

Ref.

Ref.

 T3 (≥ 94.1)

168/210

0.69 (0.53, 0.90) 0.006

0.61 (0.45, 0.83) 0.001

179/166

1.14 (0.86, 1.50) 0.362

0.89 (0.65, 1.22) 0.479

First hemorrhagic stroke

Selenium tertiles

 T1 (< 79.1 ng/mL)

26/22

Ref.

Ref.

32/32

Ref.

Ref.

 T2 (79.1 to < 94.1)

26/26

0.81 (0.33, 2.00) 0.646

0.88 (0.25, 3.04) 0.840

34/35

0.98 (0.46, 2.12) 0.962

0.48 (0.17, 1.37) 0.172

 T3 (≥ 94.1)

29/33

0.72 (0.32, 1.60) 0.420

0.80 (0.25, 2.58) 0.714

24/23

1.05 (0.43, 2.57) 0.919

0.58 (0.17, 1.92) 0.368

Selenium categories

 T1–T2 (< 94.1)

52/48

Ref.

Ref.

66/67

Ref.

Ref.

 T3 (≥ 94.1)

29/33

0.80 (0.41, 1.54) 0.506

0.86 (0.33, 2.26) 0.761

24/23

1.06 (0.54, 2.10) 0.862

0.95 (0.36, 2.46) 0.910

  1. Abbreviations: T tertile, OR odds ratio, CI confidence interval
  2. aModel 1 is conditioned on the matching factors of age and sex; model 2 is conditioned on the matching factors of age and sex, as well as adjusted for BMI, baseline SBP, baseline DBP, smoking status, alcohol consumption, labor intensity, baseline total homocysteine, vitamin E, fasting glucose, estimated glomerular filtration rate (eGFR), anti-platelet drugs, lipoprotein-lowering drugs, glucose-lowering drugs, anti-hypertensive drugs, self-reported hypertension, self-reported diabetes, self-reported atrial fibrillation, and self-reported hyperlipidemia
  3. b Adjusted P-interaction between sex and plasma selenium (T3, ≥ 94.1 ng/mL vs. T1–2, < 94.1 ng/mL) on first total stroke = 0.029
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Biology of Sex Differences

ISSN: 2042-6410

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