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Table 4 The association of plasma selenium with the risk of first stroke (total and subtypes) by sexa

From: Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study

  bMale participants Female participants
Cases/controls Model 1 Model 2 Cases/controls Model 1 Model 2
OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
First total stroke
Selenium tertiles
 T1 (< 79.1 ng/mL) 206/193 Ref. Ref. 214/224 Ref. Ref.
 T2 (79.1 to < 94.1) 218/183 1.12 (0.84, 1.49) 0.452 1.11 (0.80, 1.54) 0.519 216/219 1.04 (0.80, 1.36) 0.764 0.88 (0.65, 1.19) 0.408
 T3 (≥ 94.1) 197/245 0.73 (0.55, 0.98) 0.034 0.67 (0.48, 0.93) 0.017 204/191 1.14 (0.85, 1.54) 0.380 0.85 (0.61, 1.19) 0.353
Selenium Categories
 T1–T2 (< 94.1) 424/376 Ref. Ref. 430/443 Ref. Ref.
 T3 (≥ 94.1) 197/245 0.69 (0.54, 0.89) 0.003 0.63 (0.48, 0.83) 0.001 204/191 1.12 (0.86, 1.44) 0.399 0.92 (0.69, 1.22) 0.563
First ischemic stroke
Selenium tertiles
 T1 (< 79.1 ng/mL) 179/171 Ref. Ref. 181/192 Ref. Ref.
 T2 (79.1 to < 94.1) 191/157 1.16 (0.85, 1.57) 0.343 1.17 (0.82, 1.66) 0.387 181/183 1.05 (0.79, 1.40) 0.716 0.90 (0.64, 1.25) 0.514
 T3 (≥ 94.1) 168/210 0.74 (0.55, 1.01) 0.058 0.67 (0.47, 0.95) 0.027 179/166 1.17 (0.85, 1.60) 0.330 0.84 (0.58, 1.21) 0.347
Selenium categories
 T1–T2 (< 94.1) 370/328 Ref. Ref. 362/375 Ref. Ref.
 T3 (≥ 94.1) 168/210 0.69 (0.53, 0.90) 0.006 0.61 (0.45, 0.83) 0.001 179/166 1.14 (0.86, 1.50) 0.362 0.89 (0.65, 1.22) 0.479
First hemorrhagic stroke
Selenium tertiles
 T1 (< 79.1 ng/mL) 26/22 Ref. Ref. 32/32 Ref. Ref.
 T2 (79.1 to < 94.1) 26/26 0.81 (0.33, 2.00) 0.646 0.88 (0.25, 3.04) 0.840 34/35 0.98 (0.46, 2.12) 0.962 0.48 (0.17, 1.37) 0.172
 T3 (≥ 94.1) 29/33 0.72 (0.32, 1.60) 0.420 0.80 (0.25, 2.58) 0.714 24/23 1.05 (0.43, 2.57) 0.919 0.58 (0.17, 1.92) 0.368
Selenium categories
 T1–T2 (< 94.1) 52/48 Ref. Ref. 66/67 Ref. Ref.
 T3 (≥ 94.1) 29/33 0.80 (0.41, 1.54) 0.506 0.86 (0.33, 2.26) 0.761 24/23 1.06 (0.54, 2.10) 0.862 0.95 (0.36, 2.46) 0.910
  1. Abbreviations: T tertile, OR odds ratio, CI confidence interval
  2. aModel 1 is conditioned on the matching factors of age and sex; model 2 is conditioned on the matching factors of age and sex, as well as adjusted for BMI, baseline SBP, baseline DBP, smoking status, alcohol consumption, labor intensity, baseline total homocysteine, vitamin E, fasting glucose, estimated glomerular filtration rate (eGFR), anti-platelet drugs, lipoprotein-lowering drugs, glucose-lowering drugs, anti-hypertensive drugs, self-reported hypertension, self-reported diabetes, self-reported atrial fibrillation, and self-reported hyperlipidemia
  3. b Adjusted P-interaction between sex and plasma selenium (T3, ≥ 94.1 ng/mL vs. T1–2, < 94.1 ng/mL) on first total stroke = 0.029