Table 1 Characteristics of the studies selected for inclusion in our analysis in terms of disease stage, sex, BMI, and patient age

GSE48452 / Ahrens M. et al. 2013 [30]

10

9

4

4

41.62 ± 9.35

47.18 ± 11.34

GSE61260 /

Horvath S. et al. 2014 [31]

10

7

12

12

41.51 ± 9.09

51.55 ± 10.40

GSE66676 / Xanthakos S.A. et al. 2015 [32]

20

4

6

3

17.14 ± 1.66

53.55 ± 8.86

GSE83452 / Lefebvre P. et al. 2017 [33]

32

35

6

46

39.61 ± 11.51

N/D

(> 25 or obese)

GSE89632 / Arendt B.M. et al. 2015 [34]

2

4

14

9

39.55 ± 8.19

30.21 ± 5.51

GSE126848 / Suppli M.P. et al. 2019 [35]

6

4

9

12

40 ± 13^a

N/D (> 30)

GSE130970 / Hoang S.A. et al. 2019 [36]

4

12

13

14

44.72 ± 9.80

N/D