Fig. 5
Contractility parameters of coronary resistance artery segments induced by long-term physical exercise. a No alterations were found at 50 mmHg for spontaneous tone. (Ftraining = 1.15, Fsex = 0.404, Fint = 0.0452, dftraining = 1, dfsex = 1, dfint = 1, Ptraining = 0.293, Psex = 0.53, and Pint = 0.833). b Spontaneous tone was significantly elevated in FEx rats compared with MEx rats at 150 mmHg. (Ftraining = 0.396, Fsex = 7.089, Fint = 1.9, dftraining = 1, dfsex = 1, dfint = 1, Ptraining = 0.534, Psex = 0.013, and Pint = 0.179). c The maximum contraction ability was tested with the TxA2 agonist U46619 (10−7 M). Training significantly increased contractility in the FEx group at 50 mmHg compared with the FSe group. (Ftraining = 7.481, Fsex = 0.405, Fint = 2.51, dftraining = 1, dfsex = 1, dfint = 1, Ptraining = 0.011, Psex = 0.53, and Pint = 0.124). d At 150 mmHg, U46619 contraction was significantly higher in the FEx animals than that in the FSe and MEx animals. (Ftraining = 7.668, Fsex = 5.827, Fint = 2.28, dftraining = 1, dfsex = 1, dfint = 1, Ptraining = 0.01, Psex = 0.023, and Pint = 0.142). Two-way ANOVA with post hoc Tukey’s test. Values are the means ± SEM. #P < 0.05 vs. FSe; $P < 0.05 vs. MEx