Selective deletion of endothelial mineralocorticoid receptor protects from vascular dysfunction in sodium-restricted female mice

Table 2 Body, kidney, heart weight, and plasma Na⁺ and K⁺ in experimental groups. Measures of body weight, kidney, and heart weights expressed as a ratio to body weight as well as plasma sodium and potassium levels at sacrifice in male and female WT and KO mice on NSD or SRD. Three-way ANOVA with Sidak’s multiple comparisons test (N = 4-12)

	Male	Male	Female	Female	Male	Male	Female	Female
	WT	WT	WT	WT	KO	KO	KO	KO
	NSD	SRD	NSD	SRD	NSD	SRD	NSD	SRD
Body Wt (g)	27.7±0.9	26.0±0.8	21.8±0.9^*	20.6±0.8*^ɸ	29.4±1.4	29.3±2.2	20.7±2.0*	22.8±1.9*
Kidney/Body wt ratio	0.57±0.02	0.56±0.01	0.54±0.02	0.54±0.02	0.50±0.01^†	0.52±0.02	0.54±0.02	0.53±0.03
Heart/Body wt ratio	0.50±0.01	0.47±0.01	0.53±0.02	0.49±0.01	0.44±0.01^†	0.46±0.02	0.51±0.01*	0.47±0.01
Uterine/Body wt ratio	N/A	N/A	0.50±0.04	0.31±0.01^ϕ	N/A	N/A	0.40±0.06	0.33±0.03
Plasma Na⁺ (mmol/L)	156.4±6.8	161.0±6.7	184.2±19.3	153.7±10.7	161.2±3.4	144.3±7.7	138.0±9.9	145.2±23.3
Plasma K⁺ (mmol/L)	7.1±0.5	7.3±0.9	6.7±0.5	5.6±0.3	6.8±0.6	6.6±1.0	5.4±0.5	5.1±0.7

^*P < 0.05 vs male, ^ϕP < 0.05 vs NSD
^†P < 0.05 vs WT
Body wt: Effect of sex: *P < 0.5, Effect of KO: P = 0.1, Effect of SRD: P = 0.8
Kidney/Body wt: Effect of sex: P = 0.9, Effect of KO: P = 0.4, Effect of SRD: P = 0.9
Heart/Body wt: Effect of sex: *P = 0.01, Effect of KO: *P = 0.02, Effect of SRD: P = 0.06
Uterine/Body wt: Effect of KO: P = 0.3, Effect of Diet: *P = 0.002, Interaction: P = 0.1 (Two-Way ANOVA)
Plasma Na+: Effect of sex: P = 0.9, Effect of KO: P = 0.09, Effect of SRD: P = 0.4
Plasma K+: Effect of sex: *P = 0.01, Effect of KO: P = 0.1, Effect of SRD: P = 0.5

ISSN: 2042-6410