Fig. 7

Differentially targeted genes in astrocytes were involved in both life-sustaining and disease-relevant pathways. a Bubble plot shows significantly enriched KEGG pathways (having at least five annotated genes) with an FDR < 0.1. Gene ratio stands for the proportion of differentially targeted genes in corresponding pathways. KEGG pathways of b thermogenesis and c Huntington disease are illustrated. Differentially targeted genes are colored red (female-specific) or blue (male-specific). Saturation is commensurate to the difference in summed edge weight