Fig. 5

Core TF families were conserved in sex-specific regulatory TF-gene pairs. One row represents one TF. Light gray bins indicate that the corresponding TF was not involved in any sex-specific edge in the corresponding cell type. In each cell type, TFs were ranked based on the number of sex-specific edges from which they extend. The more sex-specific edges that a TF contributed to the PANDA network, the higher its ranking is. TFs were arranged in alphabetic order for illustration of TF families. TFs families containing member(s) ranked top 5 (colored red) in any one type of cell were viewed in zoomed-in windows. These TFs suggested seven core TF families showing remarkable property of conservation in all types of cells