Fig. 2
From: Role for ovarian hormones in purinoceptor-dependent natriuresis
Anti-natriuretic response to renal medullary P2 blockade in ovary-intact female rats only. Urinary Na+ excretion (UNaV) (a-c), urine flow (UV) (d-f), urinary K+ excretion (UKV) (g-i), and mean arterial blood pressure (MAP) (j-l) in anesthetized male, ovary-intact female, and OVX Sprague Dawley rats receiving renal medullary interstitial infusions of suramin (P2 antagonist, 750 μg/kg/min) or vehicle. n = 6-9 in each group. Statistical comparisons performed by two-way ANOVA followed by Sidak’s post hoc tests. ANOVA results: UNaV: Pinteraction = 0.1, Psuramin = 0.04, Psex = 0.9, UV: Pinteraction = 0.2, Psuramin = 0.02, Psex = 0.4; UKV: Pinteraction = 0.9, Psuramin = 0.7, Psex = 0.2; MAP: Pinteraction = 0.8, Psuramin = 0.7, Psex = 0.2