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Table 2 Interactive effects of asparagine and aspartate homeostasis with sex and age for T2D risk

From: Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk

 

Univariable model

  

Multivariable model

 
 

OR (95% CI)

P value

 

OR (95% CI)

P value

Asn > 88 vs. ≤ 88, μmol/L

1.69 (1.38–2.08)

< 0.0001

 

2.38 (1.77–3.21)

< 0.0001

Asp < 65 vs. ≥ 65, μmol/L

11.7 (6.49–21.0)

< 0.0001

 

6.33 (4.54–8.82)

< 0.0001

Asn: Asp > 1.5 vs. ≤ 1.5

7.00 (5.27–9.30)

< 0.0001

 

7.99 (5.50–11.6)

< 0.0001

Age ≥ 50 vs. < 50 years old

4.62 (3.79–5.64)

< 0.0001

 

3.96 (2.99–5.24)

< 0.0001

Female vs. male

2.55 (2.12–3.06)

< 0.0001

 

1.82 (1.38–2.42)

< 0.0001

Additive interaction model of asparagine to aspartate ratio and age a

Asn: Asp ≤ 1.5 and age < 50 years old

Reference

  

Reference

 

Asn: Asp ≤ 1.5 and age ≥ 50 years old

4.99 (2.60–9.60)

< 0.0001

 

3.43 (1.61–7.29)

0.0014

Asn: Asp > 1.5 and age < 50 years old

7.60 (4.16–13.9)

< 0.0001

 

7.10 (3.60–14.0)

< 0.0001

Asn: Asp > 1.5 and age ≥ 50 years old

37.0 (20.5–66.9)

< 0.0001

 

28.7 (14.6–56.3)

< 0.0001

Interaction measure

Estimates

  

Estimates

 

 RERI

25.4 (10.4–40.5)

  

19.2 (6.02–32.3)

 

 AP

0.69 (0.62–0.76)

  

0.67 (0.57–0.77)

 

 S

3.40 (2.64–4.39)

  

3.25 (2.32–4.55)

 

Additive interaction model of asparagine to aspartate ratio and sex b

Asn: Asp ≤ 1.5 and male

Reference

  

Reference

 

Asn: Asp ≤ 1.5 and female

2.09 (1.22–3.56)

0.0070

 

1.49 (0.76–2.93)

0.2676

Asn: Asp > 1.5 and male

6.46 (4.34–9.62)

< .0001

 

7.19 (4.41–11.7)

< .0001

Asn: Asp > 1.5 and female

21.2 (14.0–32.2)

< .0001

 

13.6 (8.10–22.9)

< .0001

Interaction measure

Estimates

  

Estimates

 

 RERI

13.7 (7.48–19.9)

  

5.95 (1.60–10.3)

 

 AP

0.64 (0.56–0.73)

  

0.44 (0.26–0.62)

 

 S

3.09 (2.35–4.05)

  

1.89 (1.32–2.71)

 
  1. Abbreviations: T2D type 2 diabetes, Asn asparagine, Asp aspartate, OR odds ratio, CI confidence interval, RERI risk due to interaction, AP attributable proportion due to interaction, S synergy index
  2. Multivariable analysis adjusted for body mass index (< 18.5, 18.5 ~ 24.0, 24.0 ~ 28.0 and ≥ 28.0 kg/m2), systolic blood pressure (< 140 and ≥ 140 mmHg), low-density lipoprotein cholesterol (< 2.60 and ≥ 2.60 mmol/L), high-density lipoprotein cholesterol (< 1.00 mmol/L in male or < 1.30 mmol/L in female as low level and ≥ 1.00 in male or ≥ 1.30 in female as high level), triglyceride (< 1.70 mmol/L and ≥ 1.70 mmol/L), and sex in a or age (< 50 and ≥ 50 years old) in b
  3. Significant elative excess risk due to interaction (RERI) > 0, attributable proportion due to interaction (AP) > 0 or synergy index (S) > 1 indicates a significant additive interaction
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Biology of Sex Differences

ISSN: 2042-6410

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