Table 2 MRI measures.
From: Sex differences in brain atrophy in multiple sclerosis
MRI measures | Healthy controls Mean ± SD cc (n) | Multiple sclerosis Mean ± SD cc (n) | Absolute difference cc | Percent difference | ‡p value q value Hedge’s g |
|---|---|---|---|---|---|
FreeSurfer thalamus | |||||
 Female | 14.88 ± 1.10 (28) | 13.91 ± 1.62 (52) | − 0.98 | − 6.8% | p = 0.0021 q = 0.0070 g = 0.66 |
 Male | 16.67 ± 0.98 (16) | 15.24 ± 1.47 (37) | − 1.43 | − 9.0% | p = 0.00015 q = 0.00075 g = 1.06 |
FreeSurfer putamen | |||||
 Female | 9.50 ± 0.97 (28) | 8.86 ± 1.17 (52) | − 0.65 | − 7.1% | p = 0.010 q = 0.020 g = 0.58 |
 Male | 11.44 ± 0.88 (16) | 10.14 ± 1.26 (37) | − 1.30 | − 12.0% | p = 0.00011 q = 0.00075 g = 1.12 |
Brain parenchymal fraction | |||||
 Female | 1088.3 ± 93.9 (28) | 1029.9 ± 85.8 (52) | − 58.4 | − 5.5% | p = 0.0086 q = 0.020 g = 0.66 |
 Male | 1235.8 ± 89.0 (17) | 1180.8 ± 78.3 (37) | − 55.0 | -4.5% | p = 0.037 q = 0.041 g = 0.67 |
Total gray matter | |||||
 Female | 585.6 ± 51.1 (28) | 555.6 ± 48.6 (52) | − 30.0 | − 5.2% | p = 0.0139 q = 0.023 g = 0.61 |
 Male | 658.0 ± 48.8 (17) | 624.1 ± 46.6 (37) | − 33.9 | − 5.3% | p = 0.0226 q = 0.028 g = 0.72 |
Total white matter | |||||
 Female | 502.7 ± 52.1 (28) | 474.3 ± 46.0 (52) | − 28.4 | − 5.8% | p = 0.019 q = 0.027 g = 0.59 |
 Male | 577.7 ± 53.7 (17) | 556.7 ± 44.1 (37) | − 21.1 | − 3.7% | p = 0.17 q = 0.17 g = 0.44 |