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Table 3 Plasma total estrogen and testosterone (TES) of Int-control, CsX, CsX-TRT, CsX-LST, and CsX-LST-TRT male SD rats

From: Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens

Group Total estrogen (pg mL−1) Testosterone (TES) (ng mL−1)
InT-control 30.7 ± 0.6 0.72 ± 0.2
CsX 30.9 ± 1.2 ---- a
CsX-TRT 31.3 ± 0.5 0.96 ± 0.1
CsX-LST 32.7 ± 0.2 ---- a
CsX-LST-TRT 33.2 ± 0.6 1.14 ± 0.1
  1. Male Sprague-Dawley (SD) rats: intact (InT-control), bilaterally castrated (CsX), and CsX with TES therapy (CsX-TRT; 1.75 mg kg−1; sc, 2x/week). In a separate experiment, CsX males were given drinking water with losartan (250 mg L−1) without TES therapy (CsX-LST) or with TES therapy (CsX-LST-TRT; 1.75 mg kg−1; sc, 2x/week). Data are means ± SEM (n = 6-13 rats per group). Neither total estrogen nor TES concentrations differed significantly among the five experimental groups (P > 0.05)
  2. aPlasma TES levels in CsX and CsX-LST groups were below the detectable limits of the radioimmunoassay